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Can your genes predict Ozempic's success? new study targets prediabetes in Mexican-Americans

NCT ID NCT05119179

First seen Mar 18, 2026 · Last updated Jun 22, 2026 · Updated 17 times

Summary

This study looks at how genetic differences in Mexican-Americans with prediabetes affect their response to semaglutide (Ozempic), a GLP-1 drug. Researchers will measure changes in insulin production, blood sugar, and gene activity in 300 participants. The goal is to find genetic markers that predict who benefits most, paving the way for personalized diabetes prevention.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UTHealth Clinical Research Unit (CRU) at UT Brownsville

    RECRUITING

    Brownsville, Texas, 78520, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Semaglutide (Ozempic)

What this could lead to

If successful, this could help doctors predict who will benefit most from GLP-1 drugs like Ozempic, leading to more personalized treatment for prediabetes and type 2 diabetes.

What could go wrong

This is an early-stage genetic study, not a treatment trial. The findings may not lead to immediate clinical changes, and individual responses to GLP-1 drugs can vary widely.

Conditions

The condition(s) this trial relates to.

prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.