ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

This study tests a new drug called UDP-003 in healthy volunteers and people with heart disease (atherosclerosis or a recent heart-related event). The main goal is to see if the drug is safe and how the body processes it. Researchers will compare UDP-003 against a placebo. The stu…

This study looks at whether taking fish oil supplements along with the standard drug metformin can help protect the heart in women with Polycystic Ovary Syndrome (PCOS). PCOS often leads to high testosterone, which can cause blood sugar and cholesterol problems, raising the risk …

This study looks at the long-term safety of a drug called pelacarsen in people with high levels of Lp(a) and heart disease. About 600 adults who finished a previous pelacarsen study can join. Researchers will track side effects and how well the drug lowers Lp(a) over time.

This study tests whether a targeted lipid optimization program helps adults in Abu Dhabi who are at high risk for heart disease reach their LDL (bad) cholesterol goals. About 326 participants will be randomly assigned to the program or usual care. The goal is to see if the progra…

This study tests whether a new medication, maridebart cafraglutide, can reduce the risk of heart attacks, strokes, and heart-related death in people who have both heart disease and are overweight or obese. About 12,800 adults aged 45 and older will receive either the drug or a pl…

This study tests a drug called CSL300 in about 2,300 adults with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if the drug can reduce the risk of heart attacks or heart-related death. Participants will receive either the drug or a…

This study looks at whether telling people their genetic risk for high blood pressure helps them make healthier choices and lower their blood pressure. Researchers will give some participants their genetic risk score along with counseling, while others get standard care. The goal…