ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

This study tested a new drug called obicetrapib in over 2,500 adults with high cholesterol or heart disease whose cholesterol was not well-controlled by their current medications. Participants took either the drug or a placebo pill daily for about 6 months. The main goal was to s…

This early-stage study tested a new drug called AZD4144 in 29 adults who have both heart disease and chronic kidney disease. The main goal was to check if the drug is safe and to see how it affects inflammation markers in the blood. Participants took either the drug or a placebo …

This study tested an experimental drug called olezarsen in 154 adults with high triglycerides (a type of fat in the blood) and either heart disease or very high triglycerides. The goal was to see if the drug could safely lower triglyceride levels more than a placebo over 6 and 12…

This study tested whether adding ezetimibe to the standard cholesterol drug atorvastatin helps very high-risk heart disease patients lower their LDL (bad) cholesterol more effectively. 137 adults with advanced heart disease participated. Results showed that the combination therap…

This study looked at whether aiming for a very low LDL (bad) cholesterol level (below 55 mg/dL) is better than a standard target (below 70 mg/dL) for people with heart or blood vessel disease. About 3,000 Asian adults took either a statin alone or a statin plus ezetimibe to reach…

This study tested a new drug called AZD0780 to see if it can lower blood pressure in people with heart disease or related risks who also have high cholesterol. About 202 adults took part, and they received either the drug or a placebo for 4 weeks. The main goal was to measure cha…

This study looked at nearly 40,000 people with a history of heart disease to measure their levels of lipoprotein(a), a type of fat in the blood that can increase heart risk. Researchers wanted to see how these levels vary among different groups of people and regions. The goal was…

This completed study surveyed 608 heart and kidney doctors to understand their awareness and use of a blood test called hsCRP, which measures inflammation. The goal was to learn what doctors think about using this test to identify inflammation in patients with heart disease, kidn…

This study looked at whether real-world data can reliably compare two diabetes drugs—tirzepatide and sitagliptin—for preventing heart attacks, strokes, or death in people with type 2 diabetes and heart disease. Researchers analyzed records from over 49,000 patients to see if this…