ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

This study tests whether olpasiran can reduce major heart problems like heart attacks and urgent procedures in people with high levels of lipoprotein(a), a genetic risk factor for heart disease. About 7,300 adults with existing heart disease and elevated Lp(a) are randomly assign…

This study follows 116 people who received an experimental gene-editing therapy for heart disease or high cholesterol. Researchers will monitor them for 15 years to see if any side effects appear and how their cholesterol levels change over time. The goal is to understand the lon…

This study observes 600 adults with heart disease who are taking a new cholesterol-lowering drug called inclisiran alongside their usual medications. Researchers will track how much their bad cholesterol (LDL-C) drops and if they reach recommended targets. The goal is to see how …

This large study tests whether a new injection called inclisiran can safely lower the risk of heart attacks and strokes in people who have already had one. Over 16,000 participants receive either the injection or a placebo. The goal is to see if this treatment reduces major heart…

This study tests a drug called inclisiran to help people with heart disease or high risk for it reach their LDL (bad) cholesterol goals. It focuses on groups like women, Black, Hispanic, and rural patients who are often undertreated. About 130 adults will receive the drug, and re…

This study tests a drug called inclisiran in over 17,000 people with heart disease. The goal is to see if it can prevent major heart problems like heart attacks, strokes, or heart-related death. Participants already take strong statins and have high LDL cholesterol. The drug is g…

This study tests whether berberine, a natural compound, can prevent heart disease and diabetes in over 2000 adults with high cardiometabolic risk (prediabetes, obesity, high blood pressure, or existing heart disease). Participants take berberine or a placebo for one year, and res…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor can also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. However, the study was withdrawn before enr…

This study was designed to see if telling patients and their doctors about calcium buildup in heart arteries (found on lung cancer CT scans) could lower the chance of death, heart attack, or stroke. It would have included adults without known heart disease who had a lung CT scan …