PREDIABETES

This study tests whether glucose-lowering medications (semaglutide and possibly dapagliflozin) can reverse prediabetes and prevent complications like eye, kidney, and nerve damage in people with heart disease. About 158 participants with prediabetes and coronary artery disease wi…

This study looks at whether eating one medium potato daily as part of a healthy Mediterranean diet affects blood sugar and heart disease risk in adults with prediabetes. About 74 people aged 25-65 with prediabetes will follow either a potato-inclusive or potato-free Mediterranean…

This study tests whether replacing regular cooking oil with diacylglycerol (DAG) oil for four weeks can improve blood sugar control and metabolism in 40 middle-aged and older adults with prediabetes. Participants will either use DAG oil or colza oil while keeping their usual life…

This small pilot study tests whether bromocriptine, a drug used for other conditions, is safe and tolerable for people with schizophrenia who also have prediabetes. Fifteen adults will take the drug for 6 weeks alongside their usual antipsychotic medications. The goal is to see i…

This study looks at whether light physical activity after meals can help control blood sugar in adults with metabolic syndrome and prediabetes. Twenty-five participants will try three routines in random order: sitting for long periods, walking for 15 minutes after eating, or doin…

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend group sessions on diet, exercise, and coping, and are paired with a community health worker fo…

This study tests whether a medication called chiglitazar sodium, combined with healthy lifestyle changes, can help people with prediabetes return to normal blood sugar levels. About 472 adults with prediabetes will take either the drug or a placebo for 52 weeks, along with lifest…

This study tests whether a daily probiotic called LP-LDL® can improve cholesterol, blood sugar, inflammation, and memory in 210 adults with prediabetes, type 1, or type 2 diabetes who also have high cholesterol or triglycerides. Participants take either the probiotic or a placebo…

This study looks at whether eating avocados regularly can improve how the body handles fats and sugar in people with prediabetes and insulin resistance. About 82 adults aged 40-70 with high triglycerides and insulin resistance will eat avocados as part of their daily diet. Resear…

This study looks at whether eating proteins and vegetables before carbohydrates (meal sequencing) can improve blood sugar control in 70 adults with diabetes or prediabetes who also experience food insecurity. Participants will receive free produce boxes and either standard nutrit…

This study tests whether a virtual health community can help people with prediabetes improve blood sugar control and prevent type 2 diabetes. Participants will receive lifestyle support through a digital platform, including education, guidance, and group interaction. The trial wi…

This study tests whether an enhanced version of the Intensive Diabetes Prevention Program (IDPP) works better than the standard program at recruiting and keeping participants in district health centres. Researchers will compare the two approaches in 170 adults with prediabetes, l…

This pilot study tests whether a single, personalized conversation with a healthcare team member or a brief message through a patient portal can encourage adults with prediabetes to take action—like joining a diabetes prevention program or starting medication. Researchers will co…

This study tests whether an enhanced diabetes prevention program that provides healthy food deliveries, exercise classes, and community resources helps African American adults with prediabetes lose more weight than a standard program. About 408 participants from low-income commun…

This study tests whether wearing a continuous glucose monitor (CGM) can motivate 50 adults with prediabetes to become more physically active. Participants will use the device for 20 days and receive education on their blood sugar levels. The goal is to see if real-time feedback e…

This study tests whether taking weekly vitamin D supplements, with doses adjusted to reach a target blood level, can help control blood sugar in 100 adults aged 30-74 who have prediabetes (high risk for type 2 diabetes). Participants are randomly assigned to receive vitamin D or …

This study looks at whether exercising in the morning or evening helps the body handle sugar better in people with prediabetes who have an extreme natural body clock. Twenty-eight adults with prediabetes and overweight will do a single cycling session at 9 AM, 5 PM, or no exercis…

This study looks at whether eating 1.5 cups of fresh mango daily for 12 weeks can improve gut health in people with prediabetes. Researchers will measure markers of gut permeability and short-chain fatty acids in blood samples from 31 participants. The goal is to see if mango con…

This study looks at how muscle cells send tiny packages called extracellular vesicles to fat cells during exercise, which may affect how the body processes sugar and fat. Researchers will compare 40 adults—some with prediabetes and some healthy—to understand why some people's fat…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect blood sugar control, blood clotting, and heart disease risk in 80 adults with prediabetes. Participants will be randomly assigned to take one sweetener or water for two week…

This study will observe 120 young adults with prediabetes to understand how different types of prediabetes relate to metabolic syndrome, a cluster of conditions that raise the risk for heart disease and diabetes. Researchers will classify participants based on blood sugar levels …

This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure …

This study will enroll about 225 adults aged 18-70 who are at risk for or may have early blood sugar problems, but not yet diagnosed with diabetes. Participants will wear a continuous glucose monitor for 10-14 days and take two at-home meal tests, followed by a standard glucose d…

This study uses a special high-frequency ultrasound to look at the layers of artery walls in people with prediabetes. The goal is to detect early signs of blood vessel damage that could lead to heart problems. Researchers will measure artery thickness in 1,740 healthy and prediab…

This study is testing a new wrist-worn device that uses light and AI to estimate blood sugar without needles. About 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days at home. The goal is to collect data to improve the device's accur…

This study will enroll 1,000 adults at high risk for diabetes to test whether continuous glucose monitors combined with artificial intelligence can detect prediabetes earlier and more accurately than current methods. Participants will wear a glucose monitor and provide health dat…

This study will give 100 adults with prediabetes a continuous glucose monitor (CGM) to see if using the device helps them lower their A1c and keep blood sugar in a healthy range. Participants will wear the sensor for several months and track their numbers. The goal is to learn wh…

This study looks at whether adding a machine-learning risk label to electronic health record messages helps adults aged 65 and older better understand their risk of developing diabetes. About 1,200 participants with prediabetes will receive either standard lab results or results …