Can a protein drink help GLP-1 users keep muscle and avoid weight regain?
NCT ID NCT07595575
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure how their bodies process protein, sugar, and insulin. The goal is to learn if these supplements support muscle health during weight loss.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- amino acid-enriched supplement beverages (Leuvate 001 and Leuvate 002)
- What this could lead to
- If successful, this could point toward a simple supplement to help people on GLP-1 drugs keep muscle and avoid regaining weight after stopping the medication.
- What could go wrong
- This is a very small, early study with only 8 people. It measures short-term body responses, not long-term weight or muscle outcomes, so results may not lead to practical advice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 8 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Be between the ages of 30 and 65 years (inclusive) * Healthy * With type 2 diabetes, pre-diabetes, obesity, overweight, or previously diabetic, obese, or overweight * Need to be on GLP-1 RA medication for no more than six months after starting the prescription. * Need to show a recent record of weight loss of 1-5 kilograms (2-11 pounds) due to the use of the GLP1-RA medication. Exclusion Criteria: * Pregnant * Smoke and use any tobacco products * A history of neuromuscular disorders or diseases that cause muscle and/or bone wasting * The chronic use of medications known to impact protein metabolism, such as corticosteroids, non-steroidal anti-inflammatory drugs, or prescription-strength acne treatments * Smoker * Excessive alcohol consumption (more than 21 units of alcohol / week; 1 unit of alcohol is approximately 25 mL of spirits (40% alcohol), 250 mL of beer (4% alcohol) or 75 mL of wine (13% alcohol) * Have health problems such as: renal or gastrointestinal disorders, metabolic disease, heart disease, vascular disease, rheumatoid arthritis, poor lung function, uncontrolled blood pressure, dizziness, thyroid problems, or any other health conditions for which you are being treated that might put you at risk for this study * Have a dairy protein allergy * Participation in another nutrition or exercise research study * Do not understand English or have a condition the PI believes would interfere with a participants' ability to provide informed consent, comply with the study protocol, or which might confound the interpretation of the study results or put someone at undue risk * Use of medications known to affect protein metabolism (i.e. corticosteroids, or prescription strength acne medications) * Consuming a vegan diet * Use of an investigational drug product or nutraceutical within the last 30 days * Any concurrent medical, orthopedic, or psychiatric condition that, in the opinion of the Investigators, would compromise the ability to comply with the study requirements
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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