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New ultrasound technique could spot artery damage years before diabetes develops

NCT ID NCT07271745

Diagnosis Sponsor: Chunyan Ma Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will use ultra-high-frequency ultrasound to measure the thickness of artery layers in 1,740 adults with prediabetes. The goal is to detect early signs of blood vessel damage that could lead to heart disease. Researchers also aim to establish normal values for healthy adults, providing a reference for earlier diagnosis and prevention.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could provide a new, non-invasive way to detect early blood vessel damage in people with prediabetes, helping prevent heart disease and stroke.
What could go wrong
This is an observational study, not a treatment trial. It will not test any drug or therapy, and the findings may not lead to immediate changes in medical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,740 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

A total of 300 prediabetic patients were selected from the physical examination center and outpatient department, and 1,440 healthy subjects were enrolled.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Prediabetic Patients Inclusion Criteria: * Impaired fasting glucose (venous plasma glucose ≥6.1 mmol/L, \<7.0 mmol/L, and \<7.8 mmol/L 2 hours after glucose loading); and/or Impaired glucose tolerance (venous plasma glucose \<7.0 mmol/L, and ≥7.8 mmol/L, \<11.1 mmol/L 2 hours after glucose loading). * Age ≥ 18 years old; * Normal blood pressure (139-90/89-60 mmHg); * Body mass index (BMI) \< 30 kg/m²; * Normal results in routine blood tests, fasting blood glucose, lipid profile, liver and kidney function tests, and electrocardiogram (ECG); * No history of cardiovascular diseases, diabetes, rheumatic connective tissue diseases, or severe liver/kidney dysfunction; * No history of acrocyanosis, no discomfort under cold stimulation, and no previous Raynaud's phenomenon in any part of the body; * No history of taking medications that affect the cardiovascular system. Exclusion Criteria : * Patients with hypertension, diabetes mellitus, hyperthyroidism, arrhythmia, etc. * Patients with connective tissue diseases such as systemic lupus erythematosus, polymyositis, rheumatoid arthritis, etc. * History of blood diseases, severe infections, or other systemic diseases. * Administration of vasoactive drugs within the past month. * Peripheral vascular diseases with arterial occlusion that prevents detection of blood flow signals. * Inability to cooperate with the examination.

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Conditions

The condition(s) this trial relates to.

prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prediabetes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    30 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Anshan Central Hospital

    Anshan, Liaoning, China

  • Beijing Hospital

    Beijing, 100000, China

  • Beijing Tiantan Hospital, Capital Medical University

    Beijing, 100000, China

  • Chaoyang Central Hospital

    Chaoyang, Liaoning, China

  • China-Japan Union Hospital of Jilin University

    Changchun, Jinlin, China

  • Henan Provincial People's Hospital

    Zhengzhou, Henan, China

  • Jiading District Central Hospital of Shanghai Municipality

    Shanghai, China

  • Jiamusi Central Hospital, Heilongjiang Province

    Jiamusi, Heilongjiang, China

  • Jiangsu Provincial People's Hospital

    Nanjing, Jiangsu, China

  • Li Huili Hospital of Ningbo Medical Center, Zhejiang Province

    Ningbo, Zhejing, China

  • Qilu Hospital (Qingdao Branch) of Shandong University

    Qingdao, Shandong, China

  • Renji Hospital, Shanghai Jiao Tong University School of Medicine

    Shanghai, China

  • Sun Yat-sen Memorial Hospital, Sun Yat-sen University

    Guangzhou, Guangdong, China

  • The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

    Shenyang, Liaoning, China

  • The First Affiliated Hospital of Dalian Medical University

    Dalian, Liaoning, China

  • The First Affiliated Hospital of Guangxi University of Chinese Medicine

    Nanning, Guangxi, China

  • The First Affiliated Hospital of Heilongjiang University of Chinese Medicine

    Harbin, Heilongjiang, China

  • The First Affiliated Hospital of Kunming Medical University

    Kunming, Yunnan, China

  • The First Affiliated Hospital of Sun Yat-sen University

    Guangzhou, Guangdong, China

  • The First Hospital of Jilin University

    Changchun, Jinlin, China

  • The First People's Hospital of Yunnan Province

    Kunming, Yunnan, China

  • The Second Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, China

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, China

  • The Second Hospital of Heilongjiang Province

    Harbin, Heilongjiang, China

  • The Second People's Hospital of Qujing City

    Qujing, Yunnan, China

  • The Third Central Hospital of Tianjin

    Tianjin, China

  • The Third People's Hospital of Yunnan Province

    Kunming, Yunnan, China

  • Tongliao People's Hospital of Inner Mongolia Autonomous Region

    Tongliao, Neimenggu, China

  • West China Hospital，Sichuan University

    Chengdu, Sichuan, China

  • Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

    Shanghai, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.