PREDIABETES

This study tests whether mirabegron, a drug currently used for overactive bladder, can improve how the body handles sugar in people with prediabetes. Researchers will measure changes in glucose tolerance, body fat, and brown fat activity in 65 adults with prediabetes. The goal is…

This study looks at whether eating peanuts every day can help control blood sugar, improve blood vessel health, and support brain function in adults with prediabetes. Researchers will enroll 72 racially diverse participants aged 20-59. Over 14 months, each person will follow both…

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. Participants receive either MOTS-c or a placebo for 12 weeks, along with lifestyle advice. The main goal is to see if MOTS-c improves how the body uses insulin, which …

This study looks at whether a pharmacist-led program using continuous glucose monitors (CGMs) can help people with prediabetes lower their blood sugar and adopt healthier habits. About 40 adults with prediabetes will wear a CGM and get guidance from a pharmacist. Researchers will…

This study tests whether a mobile app called PortionSize Ed can help 40 adults who recently had a stroke and have prediabetes or type 2 diabetes follow a Mediterranean diet. Participants use the app for 12 weeks, with some getting extra support from a dietitian. The goal is to se…

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This study tests whether using a continuous glucose monitor (CGM) along with lifestyle changes helps overweight teens with prediabetes improve insulin sensitivity. About 15 teens aged 10-17 will wear a CGM to see real-time glucose levels, aiming to boost motivation for healthier …

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This study looks at whether eating only during certain hours of the day (early or late) can help control blood sugar and improve heart health in people who are overweight and have normal blood sugar, prediabetes, or type 2 diabetes. Researchers will track blood sugar levels conti…

This study tests a supplement called Nextida GC-B in 60 adults with normal blood sugar or prediabetes. Participants take the supplement or a placebo daily for 90 days to see if it improves how the body handles sugar after meals. The goal is to find a safe way to support blood sug…

This study looks at whether artificial intelligence (AI) can give personalized tooth-brushing and flossing advice as effectively as a dentist for people with prediabetes. The goal is to reduce gum inflammation and potentially improve blood sugar levels. About 148 adults with pred…

This study tests whether a mobile health program that provides high-fiber foods and uses continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The program includes education, home-delivered high-fiber foods, and real-ti…

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study provides 400 adults with diabetes or prediabetes who face food insecurity with free fresh food boxes and nutrition education twice a month for six months. Researchers will measure changes in blood sugar levels and food security to see if this program helps control diab…

This study tests whether easy-to-use home strategies and wearable devices can reduce the negative health impact of evening screen time. Researchers will enroll 30 adults who spend at least 3 hours per day on recreational screens and have risk factors for heart disease, diabetes, …

This study looks at whether increasing physical activity and stopping evening snacking can improve metabolic health in teenagers aged 12-18 who have prediabetes. About 80 participants will be randomly assigned to either follow these lifestyle changes or receive standard care for …

This study tests a special drink called NUTIFOOD, made with carob extract, to see if it helps people with prediabetes manage their blood sugar. About 30 adults with prediabetes will drink either the test product or a placebo for a period. Researchers will measure blood sugar and …

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will take part in weekly physical activity, health education, and work with a coach and trainer. The goal is to see if the program improves heart health and reduces st…

This study tests whether limiting food intake to a 9-hour window each day (time-restricted eating) can improve heart health in 100 adults with obesity and prediabetes. Participants will follow this eating pattern for 12 weeks without changing how much they eat. Researchers will m…

This study tests whether meal replacements can help low-income adults who are overweight or have prediabetes or type 2 diabetes lose weight and lower blood sugar. About 20 participants will follow an intensive nutrition program for several weeks. The goal is to see if this approa…

This study looks at whether adding baked potatoes (with skin) to a Mediterranean diet can improve blood sugar, heart health, and diet quality in adults with pre-diabetes. Sixty people aged 45-80 will either follow the Mediterranean diet alone or with added potatoes for 12 weeks. …

This study looks at whether eating pecans instead of snacks high in bad fats and sugar can improve blood sugar and heart health in people with prediabetes. About 147 adults aged 25-65 with prediabetes will either eat 1.5 ounces of pecans daily for 16 weeks or stick to their usual…

This study looks at how different types of keto diets affect heart health and inflammation in adults who are overweight or have prediabetes or type 2 diabetes. Participants will follow either a keto diet with healthy canola oil, a traditional keto diet high in saturated fat, or a…

This study is testing a program called Regulation of Cues (ROC) for Latinas who have prediabetes and obesity. The goal is to see if the program helps them manage their eating habits, lose weight, and prevent type 2 diabetes. About 30 women aged 18-55 will take part in 14 sessions…

This study compares two newer diabetes drugs, semaglutide and dapagliflozin, against the standard drug metformin in 300 adults with prediabetes and heart artery disease. The goal is to see which drug best slows or reverses plaque buildup in heart arteries over 24 months. Particip…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This study tests whether a supplement called dihydroberberine (DHB) can help adults with pre-diabetes by improving blood sugar control, appetite, and energy. Fifty-four participants will take either DHB or a placebo daily for 6 weeks. Researchers will measure blood sugar, insulin…

This study tests whether wearing a continuous glucose monitor (CGM) and watching AI-made health videos on a smartphone can help people with prediabetes keep their blood sugar in check. About 50 adults aged 35 and older with prediabetes will use the device and videos for several w…

This study compares two ways to deliver a diabetes prevention program to 160 adults in rural communities who have prediabetes. One group will meet by video, the other will follow a self-directed plan. Researchers want to see which approach helps people lose weight and lower blood…

This study looks at whether adding hands-on nutrition demonstrations to the standard Diabetes Prevention Program helps people at risk for prediabetes stay engaged. About 20 adults in Los Angeles will take part. The goal is to see if this approach is practical and acceptable, not …

This study tests a tailored online program to help 80 UCLA undergraduates at risk for type 2 diabetes lose weight and improve health. Participants take short online lessons over 9 months and are compared to a control group. The goal is to see if the program is effective and accep…

This study tests whether adding sleep health advice and time-restricted eating to a standard diabetes prevention program helps overweight or obese adults with prediabetes lose more weight and lower their risk of developing type 2 diabetes. Forty adults will be randomly assigned t…

This study tests if adding SMS reminders with diet and exercise tips to a standard lifestyle program helps people with prediabetes lose more weight. 300 adults in Reunion Island will either get the program alone or with 72 text messages over 6 months. The goal is to see if more p…

This study tests whether teaching people with prediabetes a simple way to count carbohydrates can lower their blood sugar levels and help prevent type 2 diabetes. About 120 adults with prediabetes will either get standard lifestyle advice or extra training on counting carbs. Rese…

This study compares two ways to prevent heart attacks and strokes in people with type 2 diabetes, prediabetes, or metabolic syndrome who have no known heart disease. One approach uses a detailed CT scan to stage artery plaque buildup, while the other relies on traditional risk fa…

This pilot study tests whether a 12-week family-centered whole foods diet (without calorie counting) can help prevent type 2 diabetes in adults with prediabetes and improve eating habits for both adults and children. About 30 adult-child pairs will participate, with half receivin…

This study is testing whether using smart wearable devices and a mobile health program can help overweight or obese people with early signs of heart problems (like slightly high blood pressure or blood sugar) improve their heart health. About 1,400 adults will be tracked for 6 to…

This study tests whether adding continuous glucose monitoring (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stick with healthy habits and lower their risk of developing type 2 diabetes. About 214 adults with prediabetes will receive DPP coa…

This study tests whether combining a wearable smartwatch with personalized digital health coaching can help people at risk for or with early-stage chronic conditions (like high blood pressure, prediabetes, or obesity) become more active and improve their health. Researchers will …

This study tests whether a cold water extract from saffron tepals (the flower petals) can improve blood sugar and metabolism after a meal in 20 adults with obesity or prediabetes. Participants drink either the extract or plain water before eating white bread, then have blood test…

This study looks at how the hormone glucagon changes insulin release and blood sugar levels when people with prediabetes are fasting. Researchers will compare what happens when glucagon is given versus when sugar is given. The goal is to better understand why blood sugar rises in…

This study looks at whether short-term beetroot juice (a source of inorganic nitrate) can improve blood vessel function, insulin sensitivity, and exercise ability in people with prediabetes. Researchers will compare results between those taking metformin and those not. The goal i…

This study is looking at whether a special fat drink test can help predict who will develop type 2 diabetes. Researchers will measure blood fats and inflammation in 150 people with diabetes, prediabetes, or normal blood sugar. The goal is to find early warning signs of diabetes a…

This study looks at how insulin and glucagon interact to manage blood sugar levels when people are not eating. Researchers will compare people with normal blood sugar to those with impaired fasting glucose (a sign of prediabetes). The goal is to better understand what goes wrong …

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may lead to insulin resistance in teenagers. Researchers will collect blood samples and health information from 175 adolescents aged 14–18, including those with…

This study looks at how a person's natural sleep pattern (chronotype) affects their body's ability to handle sugar. Researchers will compare blood sugar and insulin responses in 70 overweight young adults (ages 18-23) who are either night owls or early birds. Participants will ta…

This study from Stanford University aims to understand why people's blood sugar levels respond differently to the same foods. Researchers will use continuous glucose monitors (CGMs) in 100 healthy adults, people with prediabetes, and those with type 2 diabetes to track blood suga…

This study looks at how the timing of dinner affects how the body burns fat and handles sugar. Researchers will compare early versus late dinners in healthy people and those with obesity and prediabetes. The goal is to understand if eating in sync with the body's internal clock i…

This study looks at whether a special computer program can help doctors better manage blood sugar levels in hospitalized adults. The tool alerts doctors when a patient's blood sugar is too high or too low, so they can act quickly. Researchers will track how long patients stay in …

This study looks at how an 8-week exercise program changes the bodies and cells of 40 overweight or obese adults with prediabetes. Researchers will measure weight, body fat, blood sugar, and other health markers. They will also use advanced techniques to study immune cells and fi…

This study looks at whether walking in nature or walking in built-up areas (like shopping centers) has a bigger impact on stress, anxiety, and mood in adults with prediabetes. 216 participants will walk for 150 minutes each week for six weeks in each type of environment. Research…

This study is following 1,000 people who are having bariatric surgery to see how their weight, body fat, and blood sugar levels change over two years. Participants will have tests before surgery and at several follow-up visits. The goal is to better understand the health benefits…

This study looks at how eating lean pork loin versus plant-based protein affects muscle health and blood sugar control in adults with prediabetes. Twenty participants aged 40-65 will follow special diets for 4 days. Researchers will measure muscle protein building and daily gluco…

This study follows 1,250 adults at higher risk for pancreas cancer, including those with diabetes, pancreas cysts, or a family history. Researchers collect blood samples every six months to look for early markers of the disease. The goal is to make pancreas cancer easier to detec…

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will block GLP-1's action to see how it affects insulin and glucagon. The goal is to understand early changes that lead to type 2 diabetes. Abou…

This study looks at whether connecting youth (ages 12-25) with community programs rooted in Native Hawaiian values can improve their mental and physical health. About 100 participants from the Wai'anae area will take part in cultural activities and complete surveys over several m…

This study looks at how genes influence the body's response to a hormone called GLP-1 in Mexican-Americans with prediabetes. Researchers will analyze DNA and gene activity to understand why some people respond better to GLP-1-based treatments. The goal is to find genetic markers …

This study looks at whether two common artificial sweeteners, aspartame and sucralose, change how the body handles blood sugar in adults aged 40 and older who have prediabetes. Participants will eat specially provided foods for 8 weeks while their blood sugar is tracked with a mo…

This study tests whether data from a smart ring, smartwatch, and smartphone app can identify people with prediabetes (higher-than-normal blood sugar) compared to healthy individuals. About 200 adults aged 45 and older who are overweight will wear these devices for 4 weeks and log…