PREDIABETES

This study tests whether probiotics can control blood sugar as well as metformin in people with prediabetes. Thirty adults aged 31-60 with prediabetes will take either probiotics or metformin for 13 weeks. The goal is to see if probiotics offer a new treatment option to prevent t…

This study was designed to test whether metformin, a common diabetes drug, could improve blood vessel function in people with prediabetes. It planned to enroll adults aged 18-55 with prediabetes and compare metformin to a placebo over 12 weeks. However, the study was withdrawn be…

This study tests whether eating dried Saskatoon berries daily for 10 weeks can improve blood sugar and cholesterol levels in people with untreated prediabetes or new type 2 diabetes. Researchers will compare the effects of Saskatoon berries to a control dried fruit in 92 adults a…

This study tests whether empagliflozin, a drug used for type 2 diabetes, can improve blood sugar control in 60 overweight or obese adults with prediabetes. Participants take the drug or a placebo for 13 weeks. The goal is to see if the drug helps the body use sugar better and low…

This study aims to find the best combination of diet and exercise for weight loss in 30 adults with prediabetes and physical disabilities. Participants first try either a high or low carbohydrate diet for 4 weeks. Those who lose enough weight stay on their diet; others get extra …

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose monitor and some would also use the exercise app…

This study looks at whether adding a quick blood sugar test to routine dental exams for people with advanced gum disease can help find undiagnosed high blood sugar or diabetes. About 300 adults with severe gum disease will get a finger-prick blood test during their dental visit. …

This study tests if portable devices like handheld ultrasound and blood sugar monitors can find chronic diseases such as diabetes, heart disease, and kidney disease earlier than usual. 200 adults aged 18-75 will use these devices or standard care for 6 months. The goal is to see …

This study uses artificial intelligence to examine the eyes of 100 adults with prediabetes or diabetes for early signs of diabetic retinopathy, a condition that can lead to blindness. Participants will have their retinas photographed with both stationary and mobile cameras, and a…

This pilot study looks at how stress from your surroundings affects daily blood sugar changes in 30 Hispanic adults whose parent has type 2 diabetes. The goal is to create a program using continuous glucose monitors to lower diabetes risk and inform health policies. The study is …

This study tests whether berberine, a natural compound, can prevent heart disease and diabetes in people at high risk. Over 2000 participants with prediabetes, obesity, or other risk factors are taking berberine or a placebo for one year. Researchers will check blood sugar and ch…

This study looks at whether adding a peer buddy and healthy food vouchers to a standard diabetes prevention program helps low-income adults with prediabetes stick with the program and lower their risk of developing diabetes. About 142 participants will be split into two groups: o…

This study tests whether simple, low-effort reminders (behavioral nudges) can motivate adults with prediabetes to adopt proven prevention strategies like lifestyle programs or metformin. About 960 English- or Spanish-speaking adults aged 18-80 with prediabetes and overweight are …

This study looks at whether pharmacists can help hospitality workers in New Orleans learn how to prevent diabetes. About 300 adults who are at risk for prediabetes will take part in lifestyle education sessions, receive wellness tools like fitness trackers, and get referrals to h…

This study looks at whether adding CPAP (a machine that helps you breathe at night) to a healthy lifestyle program can lower the risk of diabetes in people with prediabetes and sleep apnea. About 174 overweight or obese adults with both conditions will be followed for 6 months. T…

This study tests a new tool for doctors that uses a patient questionnaire to see how ready someone is to make lifestyle changes. Based on the results, the tool suggests ways for doctors to talk about preventing diabetes and recommends helpful resources. About 100 adults with pred…

This study looks at whether adding supervised cycling and rowing to a Mediterranean diet improves blood sugar control better than diet alone in women with prediabetes. About 30 women will be split into three groups based on their blood sugar levels and will follow the program for…

This study tests whether a combination of the diabetes drug metformin and a digital lifestyle program can prevent diabetes in adult survivors of childhood cancer who have prediabetes. About 96 participants will take metformin daily and complete online lessons over 24 weeks. The g…

This study looks at whether the amount of effort during resistance exercise (like lifting weights) changes blood sugar levels in people with prediabetes or type 2 diabetes. Fifteen participants will try a high-effort workout, a low-effort workout, and a no-exercise day. Researche…

This study looks at how eating whole wheat bread changes gut bacteria and health markers in adults with prediabetes. Over two weeks, 65 participants will eat either whole wheat or white bread daily, then provide stool, urine, and blood samples. The goal is to understand if whole …

This study looks at whether a program of exercise and a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and blood sugar control in adults who survived childhood cancer and now have prediabetes. About 20 participants will follow a …

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short bouts of morning exercise, evening exercise, and no exercise, with their blood sugar and insulin levels m…

This study looked at whether adding pramlintide to semaglutide changes appetite and eating habits in obese adults with prediabetes. Researchers planned to give 40 participants weekly semaglutide for 24 weeks, then add either pramlintide or placebo for two more weeks. The goal was…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, eggs, dairy) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study tests a new type of clinic that checks people with prediabetes and type 2 diabetes for several health problems at once, including fatty liver disease, sleep apnea, and heart failure. About 400 adults will fill out questionnaires and use simple devices to find these hid…

This study looks at whether older adults with prediabetes have slower thinking and less brain energy use compared to those with normal blood sugar. It also tests if a single dose of a ketone supplement can temporarily improve brain function. Twenty participants aged 60-75 will un…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and urine tests to find hidden signs of artery hardening and kidney damage. The goal is to learn what fact…

This study tests if wearable devices like continuous glucose monitors and the Oura Ring can remotely predict how well the pancreas is working in people with prediabetes or Type 2 diabetes. About 130 adults will wear these devices and use a smartphone app to track daily health mea…