PREDIABETES

This study tests whether a medication called chiglitazar sodium, combined with healthy lifestyle changes, can help people with prediabetes return to normal blood sugar levels. About 472 adults with prediabetes will take either the drug or a placebo for 52 weeks, along with lifest…

This study tests whether a daily probiotic called LP-LDL® can improve cholesterol, blood sugar, inflammation, and memory in 210 adults with prediabetes, type 1, or type 2 diabetes who also have high cholesterol or triglycerides. Participants take either the probiotic or a placebo…

This study tests whether medications like semaglutide and dapagliflozin can bring blood sugar back to normal in people with prediabetes and heart disease. About 158 participants will be split into two groups: one gets the drugs plus lifestyle advice, the other gets standard care.…

This study looks at whether eating avocados regularly can improve how the body handles fats and sugar in people with prediabetes and insulin resistance. About 82 adults aged 40-70 with high triglycerides and insulin resistance will eat avocados as part of their daily diet. Resear…

This study tests whether bromocriptine, a drug used for other conditions, is safe and tolerable for people with schizophrenia who also have prediabetes. Researchers will give 15 patients a low dose of bromocriptine for 6 weeks alongside their regular antipsychotic medication. The…

This study tests whether replacing regular cooking oil with diacylglycerol (DAG) oil for four weeks can improve blood sugar control and metabolism in 40 middle-aged and older adults with prediabetes. Participants will either use DAG oil or colza oil while keeping their usual life…

This study looks at whether eating a healthy Mediterranean diet that includes one medium potato each day is just as good for blood sugar and heart health as a Mediterranean diet without potatoes. About 74 adults with prediabetes will follow one of these diets for 12 weeks. Resear…

This study looks at whether eating proteins and vegetables before carbohydrates (meal sequencing) can improve blood sugar control in 70 adults with diabetes or prediabetes who also experience food insecurity. Participants will receive free produce boxes and either standard nutrit…

This study tests whether a virtual health community can help 146 adults with prediabetes improve blood sugar and prevent type 2 diabetes. Participants receive lifestyle guidance, health education, and group support through a digital platform for 6 months. The goal is to see if th…

This study tests whether wearing a continuous glucose monitor (CGM) can motivate 50 adults with prediabetes to become more physically active. Participants will use the device for 20 days and receive education on their blood sugar levels. The goal is to see if real-time feedback e…

This study looks at whether adults with prediabetes are more likely to take preventive steps—like joining a diabetes prevention program or starting medication—if they learn their personal risk. About 120 participants will either have a talk with a healthcare team member, get a me…

This study tests new strategies to help more people with prediabetes join and stick with a diabetes prevention program at district health centres. Researchers will compare tools like patient reminders and staff training to usual methods. The goal is to see if these strategies imp…

This study tests whether taking weekly vitamin D supplements, with doses adjusted to reach a target blood level, can help control blood sugar in 100 adults aged 30-74 who have prediabetes (high risk for type 2 diabetes). Participants are randomly assigned to receive vitamin D or …

This study looks at whether light physical activity after meals can improve blood sugar levels in adults with metabolic syndrome and prediabetes. Twenty-five participants will try three routines: sitting, a 15-minute walk, or brief resistance exercises like squats and calf raises…

This study will enroll 1,000 adults at high risk for diabetes to test whether continuous glucose monitors combined with artificial intelligence can detect prediabetes earlier and more accurately than current methods. Participants will wear a glucose monitor and provide health dat…

This study is testing a new wrist-worn device that uses light and AI to estimate blood sugar levels without needles. About 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers collect data to improve its accuracy. Par…

This study looks at how muscle cells send tiny packages called extracellular vesicles to fat cells during exercise, which may affect how the body handles sugar and fat. Researchers will compare 40 adults—some with prediabetes and some healthy—to understand why some people's fat c…

This study will give 100 adults with prediabetes a continuous glucose monitor (CGM) to see if using the device helps them lower their A1c and keep blood sugar in a healthy range. Participants will wear the sensor for several months and track their numbers. The goal is to learn wh…

This study looks at whether adding a machine-learning risk label to electronic health record messages helps adults aged 65 and older better understand their risk of developing diabetes. About 1,200 participants with prediabetes will receive either standard lab results or results …

This study looks at whether exercising at a specific time of day, based on your natural body clock, can help people with prediabetes manage their blood sugar better. Researchers will compare what happens when 28 overweight adults with prediabetes do no exercise, morning exercise,…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect blood sugar control and blood clotting in 80 people with prediabetes. Participants will take one sweetener or water for two weeks, and researchers will measure changes in me…

This study will use a special high-frequency ultrasound to look at the walls of arteries in 1,740 adults with prediabetes. The goal is to detect very early signs of blood vessel damage that standard tests might miss. By measuring the inner layers of arteries, researchers hope to …

This study looks at whether eating 1.5 cups of fresh mango every day for 12 weeks can improve gut health in people with prediabetes. Researchers will measure markers of gut permeability and beneficial fatty acids in blood samples already collected from a previous trial. The goal …

This study looks at 120 young adults with prediabetes to find out what factors increase their risk for diabetes and heart problems. Researchers will check things like insulin resistance, cholesterol levels, and fatty liver. The goal is to better understand how to catch and preven…