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Brain scans reveal why some shed pounds after Weight-Loss surgery and others Don't

NCT ID NCT05359887

Knowledge-focused Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses PET scans to look at the brain's reward system in 30 people who had bariatric surgery 2-3 years ago. Researchers want to see if differences in dopamine receptors explain why some patients lose more weight than others. Participants will have brain scans before and after a liquid meal to measure these changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
standardized liquid mixed meal (Nutridrink)
What this could lead to
If successful, this could help explain why some people lose more weight after bariatric surgery, potentially leading to better support or treatments for those who struggle.
What could go wrong
This is a small, early observational study with only 30 participants. It does not test a new treatment, so it may not lead to direct changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Bariatric surgery 24-36 months prior to the study * Adult (over 18y old) * Mentally capable to understand the consequences of the procedure and make his or her own choice without coercion * Able to undergo PET and MRI, according to the investigator's assessment * Native speaking * Able to participate in follow-up * Written informed consent Exclusion Criteria: * Presence of a DSM-IV axis 1 disorder * The use of drugs that bind to dopamine D2/3 receptors, including various classes of antipsychotics and antidepressants * History of stroke, brain tumor, Parkinson's Disease or dementia * History of head trauma with loss of consciousness * Alcohol or substance abuse in the last 6 months * Alcohol consumption 24h prior to PET scanning * Smoking or other forms of nicotine intake 12 hours prior to PET scanning * Use of anorectic drugs in the last 6 months * Current pregnancy * Medication for Diabetes Mellitus * Claustrophobia * The presence of implanted metal objects of the type which may concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field (such as certain implanted devices, shrapnel, ocular metal shavings) * Patients with a bodyweight \> 200kg will be excluded to ensure the maximum load of the camera bed of the PET-scanner (227 kg) is not exceeded.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • MCL

    Leeuwarden, Netherlands

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Other studies related to the condition(s) this trial covers.