University Medical Center Groningen

This study aims to see if adding a common water pill (hydrochlorothiazide) to the standard kidney-protecting drug (tolvaptan) can better slow kidney function decline and improve quality of life for people with a genetic kidney disease called ADPKD. It will involve about 300 adult…

This study is testing whether using a more focused, higher dose of proton radiation therapy can better control stage III non-small cell lung cancer while keeping severe side effects at an acceptable level. All 87 participants will receive this intensified proton treatment alongsi…

This study is testing if a drug called patiromer can help people with moderate to severe chronic kidney disease safely take higher doses of a common kidney-protecting blood pressure medication (irbesartan). In this 44-person trial, participants will try both patiromer and a place…

This study is testing if a personalized approach to giving fluids is safer and more effective than the standard one-size-fits-all method for treating sepsis in the emergency room. Sepsis is a life-threatening reaction to infection that requires rapid treatment. Researchers will c…

This study is testing whether a new 'warm' machine perfusion method can improve the function of transplanted kidneys, especially those from donors aged 50 and older. It will compare the new method against the standard 'cold' machine perfusion in 240 transplant patients. The main …

This study is testing a new decision-making tool for doctors to better diagnose appendicitis in children with sudden stomach pain. The tool uses a checklist of symptoms and a simple finger-prick blood test. Researchers want to see if this helps doctors send fewer children to the …

This study is testing a new type of orthopedic shoe called the LEEF-shoe to see if it can prevent foot ulcers in people with diabetes-related nerve damage. Thirty participants will try both the new LEEF-shoe and a standard orthopedic shoe for four weeks each to compare pressure o…

This study is testing whether a new virtual reality (VR) therapy can help people who hear distressing voices that others cannot hear. Participants will create a digital avatar of their most bothersome voice and have guided conversations with it in VR, aiming to reduce the voice's…

This small pilot study is exploring whether EMDR therapy, a treatment often used for trauma, can help reduce conditioned nausea and vomiting in cancer survivors. The therapy aims to lessen these distressing symptoms that can persist long after chemotherapy ends. Researchers will …

This study is testing whether simple at-home taste and smell exercises can help cancer patients who are taking certain medications and have noticed changes in their sense of taste. About 90 patients from 12 hospitals will either do the training or receive their usual care for 12 …

This study is testing whether a home-based 'taste steering' program can help cancer patients enjoy food more while they are on chemotherapy. It will compare the program to standard care in about 200 patients with specific cancers. The main goal is to see if the personalized taste…

This study aims to find out if a specific type of immune cell is linked to the severe fatigue that many people with Multiple Sclerosis (MS) experience. Researchers will enroll 40 people with MS to complete questionnaires, perform simple movement tasks, and give blood samples. By …

This study aims to find out if following a strict low-iodine diet for 7 days increases how much radioactive iodine the body absorbs. Researchers will measure this in 25 adults who have had surgery for thyroid cancer and are scheduled for radioactive iodine therapy. The goal is to…

This study is testing a new imaging tracer to see if it can safely and effectively show where CD8 immune cells are located in and around solid tumors. Researchers will use a PET scan with this tracer on patients with advanced solid cancers before and during immunotherapy. The goa…

This study aims to test whether a social skills assessment called the Hinting Task works well for people with Huntington's disease. Researchers will compare how 52 Huntington's patients perform on this test compared to healthy volunteers. The goal is to better understand and meas…

This study aims to find out how many patients in intensive care have undiagnosed diabetes or prediabetes, which current hospital records often miss. Researchers will measure a long-term blood sugar marker (HbA1c) in 4395 adult ICU patients to get a more accurate picture. The goal…

This study aims to understand the long-term health of children born to mothers who have had a solid organ transplant (like kidney, liver, or heart). Researchers want to see if these children have a higher risk of heart, kidney, or immune system problems later in life, possibly du…

This study is testing a new type of PET scan to see if it can help doctors select the best treatment for patients with a specific type of head and neck cancer (nasopharyngeal carcinoma). Researchers will give the scan to 10 patients before and after starting chemotherapy or radia…

This study aims to understand the different patterns of fluid buildup in people hospitalized with sudden heart failure. Researchers will observe 270 patients receiving standard diuretic treatment to see how these fluid patterns affect treatment response and recovery. The study in…

This study is exploring whether taking a daily chicory root fiber supplement for 6 weeks changes gut bacteria and immune cells in people who have had surgery for intermediate-to-high-risk melanoma. Researchers will measure substances in stool and blood to see how the supplement a…