University Medical Center Groningen

This study tests whether adding hydrochlorothiazide (a water pill) to the standard drug tolvaptan can better slow kidney decline and reduce side effects in people with autosomal dominant polycystic kidney disease (ADPKD). About 300 adults on stable tolvaptan will receive either h…

This study tests a new type of shoe (LEEF-shoe) designed to prevent foot ulcers in people with diabetes and nerve damage. About 30 adults will wear both the new shoe and standard orthopedic shoes for several weeks to compare foot pressure, comfort, and how often they wear them. T…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (low pumping function) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and improved q…

This study tests whether a new drug, vicadrostat, works differently than the older drug spironolactone when both are taken with empagliflozin. About 100 adults with chronic kidney disease and heart disease or heart failure will take one of the two combinations for 26 weeks. Resea…

This study tests whether giving fluids and blood-pressure medicine based on each person's heart response can improve care for sepsis patients in the emergency department. Sepsis is a life-threatening reaction to infection that can cause organ failure. The study will compare a per…

This study tests if warming donated kidneys from people aged 50+ for 6 hours before transplant can improve how well they work a year later. About 240 adults getting their first or second kidney transplant will take part. Half will get the standard cold storage, and half will get …

This study tests whether patiromer, a drug that lowers potassium, allows people with chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this reduces protein in the urine and lowers blood pressure, which c…

This pilot study tests whether giving a higher dose of proton therapy to the lung tumor is safe for people with stage III non-small-cell lung cancer who are also receiving chemotherapy. About 87 participants will receive the higher dose during the same number of treatment visits …

This study tests whether a decision-making tool, which includes a quick finger-prick blood test, helps general practitioners better decide which children with stomach pain need to go to the hospital for possible appendicitis. About 566 children aged 4 to 18 will take part. The go…

This study tests a new imaging method called quantitative fluorescence molecular endoscopy (qFME) to find early cancerous changes in the esophagus of people with Barrett's esophagus. Participants will receive two fluorescent dyes (bevacizumab-800CW and cetuximab-800CW) either by …

This study tests a special imaging agent (89Zr-Df-crefmirlimab) that helps PET scans show immune cells called CD8 T cells inside tumors. About 30 adults with advanced solid cancers will receive this agent before and during standard immunotherapy (PD-1 antibody). The goal is to se…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression and anxiety in adults with COPD, ALS, multiple sclerosis, or atypical Parkinson disease. 108 participants will receive either two moderate-to-high doses or two very low dos…

This study tests a home-based taste-steering program for cancer patients undergoing chemotherapy. The goal is to see if it improves food enjoyment compared to standard care. About 201 adults with certain cancers (breast, testicular, or lymphoma) will participate across 12 hospita…

This pilot study tests whether EMDR therapy can reduce conditioned nausea and vomiting in cancer survivors who had chemotherapy. Researchers will enroll 20 adults who have had cancer and still experience nausea or vomiting triggered by reminders of treatment. The goal is to see i…

This study tests whether a simple at-home taste and smell training program can improve taste function in cancer patients taking tyrosine kinase inhibitors, which often cause taste changes. About 90 adults from 12 Dutch hospitals will either do the training or receive standard car…

This study is testing a new virtual reality (VR) version of a therapy exercise for people aged 18-65 with psychiatric disorders. The goal is to see if using VR avatars in dialogue exercises is practical, acceptable, and helpful. Participants will try one VR session and share thei…

This study tests a new virtual reality (VR) therapy for people who hear voices that others cannot hear, a common symptom in mental illness. The therapy uses computer avatars to help patients gain control over the voices. Researchers will enroll 112 participants to see if the VR t…

This study tests a small, hands-free device called the PEP-buddy that helps people with COPD breathe easier during sudden breathlessness. About 25 adults with moderate to severe COPD will use the device for 4 weeks to see if it reduces shortness of breath. The goal is to find a s…

This study is creating a large database of 10,000 lung cancer patients who received radiotherapy. Researchers will collect information on tumor control, side effects, and quality of life to build models that predict treatment outcomes. The goal is to improve future treatment plan…

This study tests whether taking a daily dried chicory root supplement (a source of prebiotic fiber) for 6 weeks can change gut bacteria and immune markers in 20 people who had surgery for stage II melanoma. Researchers will measure short-chain fatty acids in stool and analyze gut…

This study tests whether using virtual reality (VR) for a therapy exercise called 'chairwork' works better than just imagining it. Thirty healthy students will try both versions and report how they feel. The goal is to see if VR helps people who have trouble imagining things get …

This study looks at how a 7-day low iodine diet changes the amount of radioactive iodine absorbed by the body in people who have had their thyroid removed due to thyroid cancer. About 25 adults will take a small dose of radioactive iodine before and after the diet to measure the …

This study is testing whether using a breathing machine (CPAP or BiPAP) during radiation therapy can reduce tumor movement in people with advanced lung cancer, esophageal cancer, or lymphoma. The goal is to see if this approach makes radiation more accurate and reduces side effec…

This study tests whether a special PET scan can show a specific protein (SSTR2) on nasopharyngeal cancer cells. Ten adults with EBV-related nasopharyngeal cancer will get the scan before and early after starting chemotherapy or chemoradiation. The goal is to see if this imaging m…

This study looks at how a treatment for severe COPD (placing valves in the lungs) changes the amount of oxygen people use during everyday activities like walking or cleaning. Researchers will measure oxygen use before and 6 months after the procedure in 20 patients. The goal is t…

This study explores how a minimally invasive lung valve treatment changes leg muscle function in people with severe emphysema. Researchers will measure muscle energy use and take small tissue samples before and 6 months after the procedure. The goal is to understand why patients …

This study observes 270 adults hospitalized with acute heart failure to identify different patterns of fluid buildup (congestion). Researchers will use ultrasound and other imaging to measure how the body responds to treatment and track outcomes like hospital stay length and reho…

This study aims to see if the Hinting Task, a test that measures how well someone understands indirect speech, can reliably detect social cognition problems in people with Huntington's disease. Researchers will compare the performance of 52 adults with Huntington's to healthy con…

This study is gathering information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when donor livers are preserved using machine perfusion. The goal is to help doctors better understand which preservation…

This study looks at a program that helps nurses from refugee or migrant backgrounds adjust to working in the Dutch healthcare system. Researchers will ask participants and their supervisors about their experiences to find out what works well and what can be improved. The goal is …

This study aims to measure tiny, short-lived molecules called free radicals in individual sperm cells using a new diamond-based sensor. Researchers want to see if these molecules, along with gut bacteria and lifestyle factors, affect male fertility. The study involves 80 men visi…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…