University Medical Center Groningen

This study tests whether giving the immunotherapy drug pembrolizumab before standard hysterectomy can shrink tumors in people with a specific type of uterine cancer (MMRd). Twelve participants will receive 9 cycles of pembrolizumab, then have surgery as planned. The goal is to se…

This study tests if the drug finerenone can reduce protein leakage in urine (a sign of kidney damage) better than a placebo. It involves 180 adults with chronic kidney disease who are not taking certain common blood pressure medicines. The goal is to see if finerenone can help co…

This study tests whether dapagliflozin, a drug originally for diabetes, can reduce the risk of death, kidney failure, or heart failure hospitalization in people with severe chronic kidney disease, including those on dialysis or with a kidney transplant. About 1,750 adults with ad…

This study compares two treatment plans for people with high-risk rectal cancer. The standard plan is long-course chemoradiation followed by surgery and optional chemo. The experimental plan starts with short-course radiation (5 days), then several months of chemo, followed by su…

This study tests a new type of PET scan that looks for a protein called PD-L1 in people with large B-cell lymphoma before they receive CAR T-cell therapy. The goal is to see if the scan can help predict who will respond to treatment and tell the difference between active lymphoma…

This study looks at why testicular cancer survivors may have a higher risk of heart disease. Researchers will follow nearly 1,000 men who had testicular cancer between 1976 and 2007, focusing on how their cancer treatment (like chemotherapy) might affect heart health over time. T…

This study looks at why certain cancer drugs cause serious heart or lung damage in some patients but not others. Researchers will take skin or blood cells from 20 people who had extreme side effects and turn them into heart cells in a lab to study the reaction. The goal is to fin…

This study looks at why some people lose more weight than others after bariatric surgery. Researchers will use brain scans (PET) to measure changes in the brain's reward system, specifically dopamine receptors, in 30 adults who had surgery 2-3 years ago. The goal is to understand…

This study looks at how the immune system in the gut changes when people with cancer receive immunotherapy. Researchers will take small tissue samples from the gut and blood samples before and during treatment. The goal is to learn more about the body's response, not to test a ne…