New combo therapy aims to boost survival in aggressive rectal cancer

NCT ID NCT01558921

Ongoing Disease control Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

First seen May 05, 2026 · Last updated May 19, 2026 · Updated 4 times

Summary

This study compares two treatment plans for people with high-risk rectal cancer. The standard plan is long-course chemoradiation followed by surgery and optional chemo. The experimental plan starts with short-course radiation (5 days), then several months of chemo, followed by surgery. The goal is to see if giving chemo earlier and more fully can reduce cancer return and improve survival. About 920 participants will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Aalborg Universitetshospital

Aalborg, Denmark
Akademiska Sjukhuset

Uppsala, Sweden
Alrijne Ziekenhuis

Leiderdorp, Netherlands
Amphia Ziekenhuis

Breda, Netherlands
Amsterdam UMC, location AMC

Amsterdam, Netherlands
Amsterdam UMC, location VUMC

Amsterdam, Netherlands
Antonius Ziekenhuis

Sneek, Netherlands
Bronovo Ziekenhuis

The Hague, Netherlands
Catharina ZIekenhuis

Eindhoven, Netherlands
Centrallasarett

Västerås, Sweden
Centrallasarettet Växjö

Vaxjo, Sweden
Centralsjukhuset i Karlstad

Karlstad, Sweden
Consorcio Hospital General Universitario Valencia

Valencia, Spain
Deventer Hospital

Deventer, Netherlands
Diakonessenhuis

Utrecht, Netherlands
Falu Lasarett

Falun, Sweden
Gävle sjukhus

Gävle, Sweden
HaGaZiekenhuis

The Hague, Netherlands
Het Groene Hart Ziekenhuis

Gouda, Netherlands
Hospital Clínico Universitario de Valencia

Valencia, Spain
Hospital Universitari i Politècnic la Fe

Valencia, Spain
Hospital Vall d'Hebron

Barcelona, Spain
ICO Hospital Duran I Reynals

L'Hospitalet de Llobregat, Spain
Institute of Oncology

Ljubljana, Slovenia
Isala Klinieken

Zwolle, Netherlands
Kalmar Hospital

Kalmar, Sweden
Karolinska Universitetssjukhuset

Stockholm, Sweden
Leiden University Medical Center

Leiden, Netherlands
Linköpings Universitet

Linköping, Sweden
Martini Ziekenhuis

Groningen, Netherlands
Medisch Centrum Haaglanden

The Hague, Netherlands
Medisch Centrum Leeuwarden

Leeuwarden, Netherlands
Mälarsjukhuset

Eskilstuna, Sweden
Nki / Avl

Amsterdam, Netherlands
Noordwest Ziekenhuisgroep

Alkmaar, Netherlands
Norrlands Universitetssjukhus

Umeå, Sweden
Odense Universitetshospital

Odense, Denmark
Onze Lieve Vrouwe Gasthuis

Amsterdam, Netherlands
Oslo Universitetssykehus

Oslo, Norway
Radiotherapeutisch Instituut Friesland

Leeuwarden, Netherlands
Reinier de Graaf Groep

Delft, Netherlands
Sahlgrenska Universitetssjukhuset

Gothenburg, Sweden
Siteman Cancer Center, Washington University Medical School

St Louis, Missouri, 63110, United States
Skaraborgs Sjukhus

Skövde, Sweden
Spaarne Ziekenhuis

Hoofddorp, Netherlands
Sundsvalls Sjukhus

Sundsvall, Sweden
Södra Älvsborgs Sjukhus

Borås, Sweden
Sørlandet Sykehus Kristiansand

Kristiansand, Norway
UMC Nijmegen St Radboud

Nijmegen, Netherlands
Universitair Medisch Centrum Groningen

Groningen, Netherlands
Universitetssjukhuset i Lund

Lund, Sweden
Universitetssjukhuset ÖREBRO

Örebro, Sweden
University Medical Center Groningen

Groningen, PO BOX 30001, 9700 RB, Netherlands
Wilhelmina Ziekenhuis

Assen, Netherlands
Ziekenhuisgroep Twente

Hengelo, Netherlands
de Tjongerschans

Heerenveen, Netherlands

Conditions

Explore the condition pages connected to this study.

RECTAL CANCER