University Medical Center Groningen

This study looks at people with high-risk thyroid cancer who need radioactive iodine treatment. After stopping their thyroid hormones to prepare for treatment, they will receive either the standard replacement or a short course of two hormones together. The goal is to see which a…

This study tests a weekly injection called survodutide in 120 adults with chronic kidney disease and high protein in their urine. The goal is to see if the drug can lower protein levels and protect kidney function over 36 weeks. Participants must already be on standard kidney med…

This study tests whether checking kidney function less often helps heart failure patients reach higher, more effective doses of their medications safely. About 344 adults with heart failure and reduced pumping ability will be randomly assigned to either standard or reduced kidney…

This study compares two heart pacing methods after a procedure to control heart rate in adults with atrial fibrillation and heart failure. Participants will receive either a new type of pacing (conduction system pacing) or standard cardiac resynchronization therapy. The goal is t…

This study looks at 720 people with a weakened heart muscle (non-ischemic dilated cardiomyopathy) and scarring seen on MRI. It tests whether implanting a defibrillator (ICD) reduces the risk of sudden death compared to medication alone. Participants with scarring are randomly ass…

This study tests whether combining two drugs, dapagliflozin and SC0062, can better protect the kidneys in adults with type 1 diabetes and chronic kidney disease. The trial will involve 36 participants who will try each drug alone and together in a random order. The goal is to see…

This study tests a new way to see lung cancer during a bronchoscopy. Doctors will use a special dye that makes cancer cells glow. The goal is to see if this helps find cancer more accurately. About 20 adults with a lung nodule that might be cancer will take part.

This study tests whether early, symptom-guided therapy can help people recover faster from mild traumatic brain injury. About 655 adults aged 18-70 will receive either physical/occupational therapy, phone-based education, or usual care. The goal is to reduce long-term complaints …

This study tests a new imaging method to see if two IBD drugs (adalimumab and risankizumab) actually reach the inflamed gut tissue. 30 adults with ulcerative colitis or Crohn's disease will receive a tiny dose of fluorescent-labeled drug before a routine colonoscopy. The goal is …

This study aims to understand how the drug canagliflozin spreads in the body of people on dialysis. Researchers will use PET scans to see where the drug goes, especially in the kidneys, heart, and brain. The goal is to learn if this drug, which helps protect the heart and kidneys…

This study looks at how well immediate dental implants with same-day temporary crowns work for replacing a single front tooth. Researchers will review records of 50 adults who had this treatment to check bone levels, implant success, and patient satisfaction after at least one ye…

This pilot study tests whether a mild electrical stimulation called TENS can change brain activity in people with Multiple Sclerosis (MS) who have fatigue and walking problems. Researchers will use brain scans (fMRI) to see how the brain responds during stimulation. The goal is t…

This early-phase study tests a new imaging method called fluorescence endoscopy to see if certain proteins (PD-1 and PD-L1) are present in esophageal cancer. About 15 participants will receive two 'glow-in-the-dark' tracers before a routine endoscopic exam. The goal is to learn w…

This study looks at people who got dental implants with a special type of denture (overdenture) in their upper jaw 15 years ago because their regular dentures didn't fit well. Researchers want to see how the bone around the implants has changed, how many implants and dentures are…