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Simple smell and taste exercises may bring flavor back to cancer patients' meals

NCT ID NCT07258589

Symptom relief Sponsor: University Medical Center Groningen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This study tests whether a 12-week at-home taste and smell training program can improve taste function in cancer patients who experience taste changes from tyrosine kinase inhibitors. Ninety participants across 12 Dutch hospitals will be randomly assigned to the training or standard care. Researchers will measure taste and smell before and after the program, along with food enjoyment and other outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
taste and smell training
What this could lead to
If it works, this simple at-home training could help cancer patients enjoy food more and reduce taste problems caused by their medication.
What could go wrong
This is a small, early-stage trial with only 90 participants, and the training may not improve taste or smell for everyone. Results may not apply to all cancer patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 and ≤70 years * Intention of being treated with tyrosine kinase inhibitors for next 12 weeks. * Experiencing taste alterations after starting treatment with tyrosine kinase inhibitors * Consuming solid foods and drinks is possible * ≤50% of recommended daily intake in kcal consisting of oral nutritional supplements * Oral mucositis grade ≤2 (Common Terminology Criteria for Adverse Events, version 5.0) * Ability to comply with all protocol-required actions * Written informed consent Exclusion Criteria: * Pregnancy * History of taste, smell, or saliva production dysfunction before treatment with tyrosine kinase inhibitors * Previous or current radiotherapy of head and neck region * Enteral feeding through tube or parenteral feeding * Participation in another clinical trial aimed at preventing or treating taste and/or smell alterations * Chronic (\>1 month) high dose corticosteroids (\>10 mg prednisone/day or equivalent)

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Conditions

The condition(s) this trial relates to.

cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oncological patients Patients who are treated with tyrosine kinase inhibitors Tyrosine kinase inhibitor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Amsterdam UMC

    RECRUITING

    Amsterdam, Netherlands

  • Ikazia Ziekenhuis

    RECRUITING

    Rotterdam, Netherlands

  • Isala Klinieken

    NOT_YET_RECRUITING

    Zwolle, Netherlands

  • Martini Ziekenhuis

    RECRUITING

    Groningen, Netherlands

  • Maxima Medisch Centrum

    NOT_YET_RECRUITING

    Veldhoven, Netherlands

  • Ommelander Ziekenhuis Groningen

    RECRUITING

    Scheemda, Netherlands

  • Radboud University medical Center

    NOT_YET_RECRUITING

    Nijmegen, Netherlands

  • Rijnstate Ziekenhuis

    NOT_YET_RECRUITING

    Arnhem, Netherlands

  • University Medical Center Groningen

    RECRUITING

    Groningen, 9713 GZ, Netherlands

  • Van Weel-Bethesda Ziekenhuis

    NOT_YET_RECRUITING

    Dirksland, Netherlands

  • Ziekenhuisvoorzieningen Gelderse Vallei

    RECRUITING

    Ede, Netherlands

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