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Cure My Disease

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Can a weekly shot stop weight regain? new study hopes so.

NCT ID NCT06859268

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an investigational drug called retatrutide in 643 adults with obesity. The goal is to see if it helps maintain weight loss over about 2.5 years. Participants first take the drug for 80 weeks, then are randomly assigned to continue the drug or switch to a placebo for 36 more weeks. The study measures weight, waist size, and quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 643 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have obesity and a history of at least one self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days before screening * Have a prior or planned surgical treatment for obesity * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity * Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes * Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) * Have had within the past 90 days before screening: * acute myocardial infarction * cerebrovascular accident (stroke) * hospitalization for unstable angina, or * hospitalization due to congestive heart failure * Have New York Heart Association Functional Classification Class IV congestive heart failure * Have a history of chronic or acute pancreatitis * Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • ALL Medical Research, LLC

    Cooper City, Florida, 33024, United States

  • Aggarwal and Associates Limited

    Brampton, L6T 0G1, Canada

  • Alliance for Multispecialty Research, LLC

    Oak Brook, Illinois, 60523, United States

  • Alliance for Multispecialty Research, LLC

    Lexington, Kentucky, 40509, United States

  • Alliance for Multispecialty Research, LLC

    Kansas City, Missouri, 64114, United States

  • Alliance for Multispecialty Research, LLC

    Knoxville, Tennessee, 37909, United States

  • Altoona Center For Clinical Research

    Duncansville, Pennsylvania, 16635, United States

  • Atlantic Medical

    Penzance, TR18 3DX, United Kingdom

  • Bradford on Avon Health Centre

    Bradford-on-Avon, BA15 1DQ, United Kingdom

  • C.I.C. Mauricie inc.

    Trois-Rivières, G8T 7A1, Canada

  • CMR of Greater New Haven, LLC

    Hamden, Connecticut, 06517, United States

  • Care Access - Houston

    Houston, Texas, 77054, United States

  • Care Access - Lake Charles (Bayou Pines)

    Lake Charles, Louisiana, 70601, United States

  • Care Access - Raleigh

    Raleigh, North Carolina, 27607, United States

  • Care Access - Rapid City

    Rapid City, South Dakota, 57701, United States

  • Care Access - Thunder Bay - Barton Street

    Thunder Bay, P7B 7C7, Canada

  • Carteret Medical Group

    Morehead City, North Carolina, 28557, United States

  • Central Washington Health Services Association d/b/a Confluence Health

    Wenatchee, Washington, 98801, United States

  • Centre de Medecine Metabolique de Lanaudiere (CMML)

    Terrebonne, J6X 4P7, Canada

  • Charter Research - Winter Park

    Orlando, Florida, 32803, United States

  • Cheadle Community Hospital

    Cheadle, ST10 1NS, United Kingdom

  • Circulate Cardiac & Vascular Centre

    Burlington, L7M 1K9, Canada

  • Dent Neurosciences Research Center, Inc

    Amherst, New York, 14226, United States

  • Florida International Medical Research

    Coral Gables, Florida, 33134, United States

  • FutureMeds - Birmingham

    Birmingham, B21 9RY, United Kingdom

  • FutureMeds - Liverpool

    Bromborough, CH62 6EE, United Kingdom

  • HMC Health Group - Meadows Centre for Health

    Hounslow, TW4 7NR, United Kingdom

  • Kubost Clinical Research - Marietta

    Marietta, Georgia, 30062, United States

  • L-MARC Research Center

    Louisville, Kentucky, 40213, United States

  • Layton Medical Centre

    Blackpool, FY3 7EN, United Kingdom

  • Maple Leaf Research

    Toronto, M5G 1K2, Canada

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Med Trust Research

    Courtice, L1E 2J5, Canada

  • Metabolic Research Institute, Inc.

    West Palm Beach, Florida, 33401, United States

  • National Clinical Research, Inc

    Richmond, Virginia, 23294, United States

  • North Georgia Clinical Research

    Woodstock, Georgia, 30189, United States

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Oakenhurst Medical Practice

    Blackburn, BB2 1AX, United Kingdom

  • Pacific Diabetes & Endocrine Center

    Honolulu, Hawaii, 96817, United States

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana, 70808, United States

  • Rame Group Practice

    Torpoint, PL11 2TB, United Kingdom

  • Renstar Medical Research

    Ocala, Florida, 34470, United States

  • Sleep Therapy Research Center

    San Antonio, Texas, 78229, United States

  • Southern California Clinical Research

    Santa Ana, California, 92701, United States

  • Southern Endocrinology Associates

    Mesquite, Texas, 75149, United States

  • Springfield Clinic Main Campus

    Springfield, Illinois, 62703, United States

  • St Bartholomew's Medical Centre

    Oxford, OX4 1XB, United Kingdom

  • Tekton Research, LLC.

    Moore, Oklahoma, 73160, United States

  • The Adam Practice

    Poole, BH16 5PW, United Kingdom

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • Vector Clinical Trials

    Las Vegas, Nevada, 89128, United States

  • Winterberry Research Inc.

    Hamilton, L8J 0B6, Canada

  • Woodstock Bower Surgery

    Rotherham, S61 1AH, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.