New nerve block may ease breathing after shoulder surgery in obese patients
NCT ID NCT07216820
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compares two types of nerve blocks for shoulder surgery in adults with obesity. The standard block can sometimes weaken breathing muscles, while the experimental 'phrenic-sparing' block aims to avoid that. Researchers will measure breathing problems and pain control in 68 participants to see if the new block is safer and just as effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nerve block (bupivacaine and dexamethasone injection)
- What this could lead to
- If successful, this approach could reduce early breathing difficulties after shoulder surgery in people with obesity, improving recovery and safety.
- What could go wrong
- This is a small, early-phase trial (68 participants) focused on short-term outcomes, so results may not apply broadly. The phrenic-sparing block may also provide less effective pain control.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 68 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years (self-report, confirmed on chart). * Body-mass index ≥ 35 kg m\^2 at the pre-operative clinic visit (chart). * Scheduled for elective unilateral shoulder surgery (arthroscopy, arthroplasty, rotator cuff repair, reverse arthroplasty) under general anesthesia at UNC Hospitals * Planned use of a single-injection regional brachial-plexus block for postoperative analgesia (anesthesia record). * Able to perform a maximal-inspiratory-pressure (MIP) maneuver at screening, producing two reproducible efforts (bedside test) * Able to read or understand English and provide written informed consent (consent discussion). Exclusion Criteria: * Emergent or trauma shoulder procedure or case converted to open surgery (schedule/chart). * Pregnancy confirmed by point-of-care urine test on day of surgery (POC test). Prisoner status or legal incapacity to consent (chart/interview). * Severe pulmonary disease: GOLD stage 3-4 COPD, restrictive lung disease unrelated to obesity with FVC \< 50 % predicted, baseline dyspnea Borg ≥ 3, or home oxygen therapy (pulmonary clinic notes, patient interview). * Severe heart disease- Severe valvular heart disease, Congestive Heart Failure NYHA Class III or IV, Obstructive Coronary Artery Disease with Angina * Neuromuscular disorders affecting respiratory muscles (e.g., ALS, myasthenia gravis) or known diaphragmatic paralysis (chart). * Coagulopathy (platelets \< 100 × 10/ L or INR \> 1.5) or local infection at block sites (pre-op labs/assessment). * Anemia and hemoglobinopathies: Hgb \<10 g/dl, clinically significant hemoglobinopathy. * Allergy to bupivacaine, dexamethasone, or ultrasound gel (self-report). * Chronic opioid use \> 100 mg oral-morphine equivalents per day in the three months preceding surgery (medication history, PDMP query). * Prior enrolment in this trial or planned participation in another interventional study that might confound outcomes (research registry). * Anticipated inability to comply with postoperative assessments (e.g., profound cognitive impairment, expected early transfer to outside facility) as judged by the investigator
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of North Carolina Hospitals
RECRUITINGChapel Hill, North Carolina, 27599, United States
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