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Scientists probe Fat-Gut-Brain link in obesity study

NCT ID NCT06869941

Knowledge-focused Sponsor: Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how fat tissue and gut bacteria might influence memory and thinking in people with and without obesity. Researchers will analyze tissue, blood, and stool samples from 100 adults scheduled for surgery. The goal is to uncover new ways obesity affects the brain, which could lead to better treatments for cognitive problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

We will make use of the existing samples from the FATBANK cohort (a platform driven by CIBEROBN, managed by the IDIBGI Biobank, and part of the Spanish National Biobank Network). Participants in this cohort had previously signed informed consent to be contacted again. Therefore, the selected participants will be reappointed at the Endocrinology, Diabetes, and Nutrition Service (UDENTG) of the Dr. Josep Trueta Hospital.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women \>20 years old. * Scheduled for surgical intervention to extract adipose tissue. * Signed informed consent for study participation. Exclusion Criteria: * Not meeting inclusion criteria. * Non-obesity-related systemic diseases (cancer, severe kidney/liver disease). * Systemic diseases with intrinsic inflammation (rheumatoid arthritis, Crohn's disease, asthma, chronic infections (HIV/tuberculosis)) or any type of infectious disease. * Pregnant/breastfeeding women. * Persons under legal/administrative restrictions. * Those with infection symptoms in the past month. * Use of antibiotics/antifungals/antivirals (previous 3 months). * Chronic steroidal/anti-inflammatory drug use. * Major psychiatric history. * Excessive alcohol intake, acute or chronic (\>40g/day (women), \>80g/day (men)) or drug abuse. * Immunosuppressants treatment. * Participants with severe eating disorders. * Serum liver enzymes (GOT, GPT) above twice the upper limit of normal. Obvious signs or symptoms of liver disease, acute or chronic hepatitis. * History of iron balance disorders (e.g., genetic hemochromatosis, hemosiderosis from any cause, atransferrinemia, paroxysmal nocturnal hemoglobinuria). * Creatinine greater than 1.2 and glomerular filtration rate below 40. * Current treatment for malignant neoplasia, other than basal cell or squamous cell skin cancer. * Heart disease classified as class III or IV, known ischemic cardiovascular disease. * Renal failure, history of kidney transplant, or current dialysis treatment. * Chronic constipation (bowel movement frequency ≥ 7 days) .

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Institut d'Investigació Biomèdica de Girona (IDIBGI)

    RECRUITING

    Girona, Girona, 17007, Spain

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