Can stress make painkillers more risky? new study investigates
NCT ID NCT05142267
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 31 times
Summary
This study looks at how stress changes the way opioid painkillers work in people with chronic back pain. Researchers will give participants oxycodone, a pain blocker, or a placebo in a lab setting to measure pain relief and drug liking. The goal is to understand why some people may be at higher risk for misusing pain medications when stressed.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37212, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Oxycodone and naloxone (given in controlled lab sessions to study pain response)
What this could lead to
If successful, this study could help identify why some people are more likely to misuse opioid painkillers, leading to better prevention strategies.
What could go wrong
This is an early-stage observational study with only 120 participants. Results may not apply to everyone, and the lab setting may not reflect real-world stress and pain.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.