Psychiatric disorder

This trial tests a gene therapy for metachromatic leukodystrophy (MLD), a rare inherited disease that damages the nervous system. Researchers take a patient's own blood stem cells, add a corrected gene, and infuse them back. The goal is to see if this approach is safe and can slo…

This trial tests whether a smartphone app can enhance parent management training (PMT) for children aged 8 to 13 with disruptive behavior disorders, such as conduct disorder or ADHD. Parents receive 12 weekly PMT sessions, and half also use a digital tool with videos, a resource …

Researchers at UT Southwestern Medical Center are testing whether tirzepatide, a drug approved for diabetes and weight loss, can help people with moderate to severe methamphetamine use disorder reduce or stop using the drug. The trial enrolls 228 adults aged 18 to 65 who are over…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This Phase 3 trial is testing whether adding lurasidone—a medication typically used for other mental health conditions—can help adults with major depressive disorder who haven't improved enough on an antidepressant alone. Participants will keep taking their current antidepressant…

This study tests whether a special low-calorie, plant-based diet taken for 5 days each month can safely improve blood flow to the brain in middle-aged adults who carry the APOE4 gene, which raises Alzheimer's risk. Forty participants aged 45-65 will be randomly assigned to either…

This pilot study will test whether deep brain stimulation (DBS) can help people with schizophrenia who still hear voices and have delusions despite trying multiple medications. Fifteen adults will have electrodes placed in a brain region linked to schizophrenia symptoms. The goal…

This phase 2 trial explores whether fecal microbiota transplantation (FMT) is safe, tolerable, and practical for adolescents aged 13–17 with ADHD. Participants receive oral FMT capsules after bowel prep, alongside antibiotics, to see if changing gut bacteria can influence ADHD sy…

Researchers at Yale are studying whether a prescription app called Rejoyn, which provides cognitive behavioral therapy exercises, can be a useful addition to standard depression treatments like TMS or esketamine. The study will enroll 50 adults with major depressive disorder who …

This trial tests whether transcranial magnetic stimulation (TMS) aimed at a brain circuit linked to the subgenual anterior cingulate cortex can reduce depression symptoms. Adults with major depressive disorder or persistent depressive disorder will receive either active or sham T…

This early-stage study at Yale is testing whether a combination of two medications (naltrexone and bupropion) plus cognitive-behavioral therapy can help people who are considering bariatric surgery lose weight and stop smoking. Twenty participants will receive the treatment for f…

This trial tests a brain stimulation technique called sequential dual-site accelerated theta burst stimulation (SD-aTBS) in adults with schizophrenia who have cognitive impairment. The treatment targets two brain networks involved in thinking and memory. Researchers will compare …

This pilot study tests whether a structured care program called CARIBOU can reduce depressive symptoms in adolescents aged 15 to 18 with major depression. The program combines cognitive behavioral therapy, caregiver support, and medication management when needed, all coordinated …

This study investigates whether Shugan Jieyu Capsules, a traditional Chinese herbal medicine, can effectively treat depression of varying severity in everyday clinical practice. Researchers will follow 400 patients aged 13-65 with depression, giving them the capsules alone or alo…

This pilot study tests whether electroconvulsive therapy (ECT) can improve thinking and memory in people with Alzheimer's disease. ECT is a procedure that uses electrical stimulation to trigger a controlled seizure under anesthesia, and it is already used for severe depression. R…

This trial tests whether two types of talk therapy, Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT), can ease depression and related issues better than usual care in people who have major depression and are facing marital crisis. About 120 adults wi…

This trial tests whether a non-invasive brain stimulation technique called HD-tACS can reduce alcohol cravings and help prevent relapse in people with alcohol use disorder. Participants receive either real or sham stimulation for 20 minutes, three times a day, over 10 days. Resea…

This phase 2 trial is testing whether an experimental drug called BMS-986511 can reduce symptoms of major depressive disorder in adults. Participants with moderate to severe depression will receive either the drug or a placebo, and researchers will track changes in depression sco…

Researchers at UC San Diego are testing whether a computer-based working memory training session, done right before a brief exposure exercise, can improve fear extinction learning in adults with social anxiety disorder. Participants will be randomly assigned to either the working…

This trial tests whether a type of brain stimulation called accelerated deep transcranial magnetic stimulation (dTMS) can help reduce weight gain caused by antipsychotic medications in people with schizophrenia. Participants receive either real or sham stimulation after being exp…

This trial tests a program called ROOTS that places substance use counselors and peer recovery specialists directly in rural schools. The goal is to see if this approach helps teens who are referred or seek help on their own to engage in treatment and reduce their substance use. …

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This trial tests whether a brief counseling session followed by an 8-week smartphone program can help rural adults who drink heavily and live with chronic pain. Participants are recruited online and complete all study steps through videoconferencing. After a first assessment, the…

This study asks whether tapering and stopping certain psychotropic medications before intensive trauma-focused psychotherapy helps people with PTSD more than continuing those medications during therapy. Researchers will compare patients treated under a new medication-review polic…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can reduce drug cravings in people with methamphetamine use disorder. The stimulation targets the nucleus accumbens, a brain region involved in reward and a…

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This study follows 250 Chinese adults with schizophrenia who are prescribed KarXT, a combination of xanomeline and trospium chloride. Over 17 weeks, researchers observe how doctors use the drug, how well patients stick with it, and what side effects occur. The goal is to see if K…

Researchers are testing whether a gentle electrical stimulation on the ear, called taVNS, paired with mouth and tongue exercises can help infants with severe swallowing difficulties. The trial will include 12 infants in the NICU who have trouble sucking and swallowing. Over three…

Researchers are testing whether lemborexant, a sleep medication, can help people with moderate to severe cannabis use disorder cut back on cannabis, improve sleep, and ease withdrawal symptoms. The trial compares 21 nights of lemborexant against a placebo, with participants also …

Researchers are testing whether a personalized form of brain stimulation can ease symptoms in people with anxiety disorders that have not improved with standard treatments. The approach uses a device to deliver rapid magnetic pulses to specific brain circuits, guided by each pers…

This trial tests whether adding behavioral activation therapy to intravenous ketamine helps people with treatment-resistant depression more than ketamine alone. Adults aged 18 to 65 who have not improved with at least two antidepressants will receive ketamine infusions twice week…

Researchers at the University of South Florida are testing whether a daily probiotic fermented milk drink can improve gut health and reduce inflammation in people with Alzheimer's disease and related dementias, as well as their caregivers. The study will give 40 participants eith…

This trial compares three common anesthetics, ciprofol, propofol, and sevoflurane, to see which one best prevents delirium, a sudden state of confusion and memory problems, in older adults after brain tumor surgery. About 381 people aged 65 to 90 will be randomly assigned to rece…

This trial tests whether fluoxetine, a common antidepressant, can improve bowel function in adults with chronic constipation that has not responded to standard laxatives. Participants also show features of somatic symptom disorder, where emotional distress appears as physical sym…

This study tests whether peer support specialists—people who have been through liver transplant for alcohol-related disease themselves—can help others in the same situation stay sober and attend medical appointments. About 95 participants will meet regularly with a peer supporter…

This pilot trial tests two online parenting programs designed for parents who struggle with anger and conflicts with their children. One program teaches standard behavioral parenting strategies, while the other adds emotion regulation techniques to help parents manage their own r…

This trial compares two models of doula support for pregnant people on Medicaid in North Central Florida. One group receives enhanced support that starts earlier in pregnancy, happens more often, and continues through the first year after birth. The other group receives standard …

This trial tests a personalized approach to maintaining improvement in people with treatment-resistant depression. Participants who previously responded to a type of brain stimulation called iTBS will receive maintenance stimulation scheduled by a symptom-based algorithm, along w…

This trial tests a gene therapy for X-linked adrenoleukodystrophy (X-ALD), a rare genetic disease that damages the brain. The therapy uses a modified virus to deliver a working copy of the faulty gene directly into the spinal fluid and bloodstream. Up to 30 patients aged 1 year a…

This trial tests a gene therapy for metachromatic leukodystrophy (MLD), a rare and life-threatening genetic disorder that damages the nervous system. The treatment uses a lentivirus to deliver a working copy of the ARSA gene directly into the spinal fluid and bloodstream. Up to 1…

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people who have had a brain hemorrhage (a type of stroke) recover better and avoid future heart attacks or strokes. About 1,125 adults with signs of artery disease will take either colchicine or…

This phase 2 trial tests whether terazosin, a drug already used for high blood pressure, can increase energy production in the brains of people with Alzheimer's disease. Researchers will give 100 participants either terazosin or a placebo for 78 weeks and measure ATP, the body's …

This trial tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in people with spinocerebellar ataxia type 3, a genetic condition that affects coordination and balance. The stimulation targets a deep brain region involved i…

This trial tests a web-based tool called PRADA that uses a person's genetics, symptoms, and preferences to help choose an antidepressant. Researchers will compare it to an older tool in adults with major depression across Ethiopia, Pakistan, and the UK. The goal is to see if the …

This trial tests whether adding a special diet to standard care helps children aged 3 to 8 with autism spectrum disorder. Researchers compare three diets: a low glycemic index diet, a modified Atkins diet, and a gluten-free casein-free diet. The goal is to see if any diet reduces…

This trial tests whether adding a daily probiotic supplement to standard antidepressant medication can improve depression symptoms and reduce stress. Adults aged 18-65 with a confirmed depression diagnosis and stable antidepressant use will take the probiotic or a placebo for 12 …

This trial tests whether transcranial magnetic stimulation (TMS) can engage the amygdala—the brain's fear center—in adults with post-traumatic stress disorder (PTSD). Participants receive either active or sham TMS every weekday for six weeks, guided by MRI to target a personalize…

This trial tests whether a combination of two antiretroviral drugs, emtricitabine and tenofovir, is safe and tolerable in older adults with early Alzheimer's disease. Participants take the drug or a placebo daily for 28 days, then undergo blood tests, cognitive checks, and brain …

This phase 3 trial is testing whether lumateperone (Caplyta), taken alone, can reduce symptoms of major depressive disorder (MDD) compared to a placebo. About 585 adults with MDD will receive one of two doses of lumateperone or a placebo for six weeks, followed by a long-term ext…

This trial tests whether a daily pill called obicetrapib can slow early brain changes linked to Alzheimer's disease. Researchers will give the drug or a placebo to 400 adults who have signs of Alzheimer's-related proteins but no memory symptoms yet. The study measures changes in …

This study tests a brain-computer interface called BrainGate2 in people with expressive aphasia, a condition where stroke damage makes it hard to speak. Researchers place small sensors in the brain areas that control speech, then record brain activity while participants try to sp…

Researchers at Massachusetts General Hospital are testing whether daily oral thiamine, also known as vitamin B1, can reduce depression symptoms in children and adolescents aged 8 to 17.5 with major depressive disorder. Participants take a 100 mg thiamine capsule daily for 4 weeks…

This trial tests whether propranolol, a blood pressure drug, can reduce PTSD symptoms in women who have experienced severe violence. Participants take propranolol and then revisit their traumatic memories in a structured session with a psychologist. The study compares this approa…

This phase 3 trial tests whether adding an experimental drug called brenipatide to standard depression treatment can delay the return of major depressive symptoms in adults with major depressive disorder. Participants receive either brenipatide or a placebo by injection, alongsid…

This Phase 2a trial tests an oral drug called GAL-101 in about 100 people with mild to moderate Alzheimer's disease. Participants take either 1200 mg of GAL-101 or a placebo pill once daily for 28 days, and neither they nor the study team know which they receive. The main goal is…

This study tests a program called STORC, which trains a support person chosen by the mother and pairs her with a patient navigator to help her find resources after giving birth. The goal is to increase 'recovery capital'—the personal and social resources that help people with opi…

This study tests whether regular, one-on-one conversations with an AI can improve social confidence and engagement in adults aged 75 and older who have mild cognitive impairment and are socially isolated. Participants will have AI-led chats designed to stimulate thinking and soci…

This trial asks whether adding intranasal insulin or empagliflozin to standard anti-amyloid therapy can improve outcomes for people with mild cognitive impairment or early Alzheimer's disease. Participants will receive one of the two study drugs or a placebo, alongside their pres…

This early-stage trial is testing whether combining a type of brain stimulation called TMS with two medications—D-cycloserine and lurasidone—can improve symptoms in adults with moderate to severe depression. Participants will receive the combined treatment and be monitored for si…

This trial tests whether pregnenolone, a natural hormone, can help adults with both alcohol use disorder and major depression. Participants take either pregnenolone or a placebo for 12 weeks, while researchers track drinking, cravings, and mood. Brain scans will also look at how …

This trial tests whether an experimental drug called RO7568282 can slow the progression of early Alzheimer's disease. About 450 people with mild cognitive impairment or mild dementia due to Alzheimer's will receive either the drug or a placebo for 72 weeks. Researchers will measu…

This trial tests whether a compound called 2-HOBA can safely reduce harmful protein modifications in the brain that are linked to Alzheimer's disease. About 48 people with mild cognitive impairment or mild Alzheimer's will take either 2-HOBA or a placebo daily for 12 weeks. Resea…

This trial tests whether different types of appointment reminder calls can improve attendance at a smoking cessation clinic. Adult smokers scheduled for a follow-up visit will receive either a standard reminder call or a call that includes behavioral 'nudges' based on the MINDSPA…

This phase 2 trial is testing whether a one-day treatment combining repetitive transcranial magnetic stimulation (rTMS) with the drug D-cycloserine can help military personnel and veterans with PTSD. The study will enroll 50 participants who will receive either the active treatme…

This trial tests whether a program that offers incentives for continuing treatment can help pregnant and postpartum people with substance use disorder stay engaged in care. Participants receive screening for social needs and are randomly assigned to either usual care or a conting…

This trial investigates whether semaglutide, a medication used for diabetes and obesity, can help reduce alcohol cravings and drinking in adults with alcohol use disorder and obesity. Participants will receive either a low dose, a high dose, or a placebo for 20 weeks. The study t…

This phase 2 trial is testing whether a single day of repetitive transcranial magnetic stimulation (rTMS), combined with a dose of D-cycloserine, can help first responders with post-traumatic stress disorder (PTSD). About 50 participants will receive either the active treatment o…

This trial tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce depressive symptoms in women who are pregnant or up to 12 months postpartum. rTMS uses a scalp device to deliver gentle magnetic pulses to a brain area involved in mood, without medication or …

This trial evaluates PULS, a cognitive behavioral treatment designed to promote prosocial behavior and reduce criminal attitudes, for youth aged 16-21 placed in Swedish institutional care due to criminal involvement. The study compares PULS plus usual care against usual care alon…

This trial investigates whether semaglutide, a medication used for diabetes and obesity, can help adolescents aged 12-18 with autism spectrum disorder (ASD) and obesity reduce their body mass index (BMI). Participants will receive either semaglutide injections or lifestyle counse…

This trial tests whether combining brain stimulation with physical therapy can improve walking in adults with functional neurological disorder (FND), a condition where the brain's movement signals are disrupted. Participants receive either TMS-enhanced physical therapy or standar…

This trial is testing whether a personalized form of brain stimulation, called accelerated intermittent theta-burst stimulation (iTBS), can improve symptoms of depression and anxiety in people with treatment-resistant depression. The approach uses brain imaging to target specific…

This trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…

This trial tests a six-session peer-led program called Gwan Enjoy Life for sexual minority men living with HIV in Jamaica. The program aims to reduce depression, anxiety, and loneliness while helping participants stay engaged in HIV care and take their medications. Sixty men will…

This phase 2 trial tests whether adding a combination of deferiprone (an iron-chelating drug) and N-acetylcysteine (an antioxidant) to standard antipsychotic treatment can reduce the negative symptoms of schizophrenia, such as apathy, lack of motivation, and social withdrawal. Ab…

This study tests whether screening for elder neglect in primary care, combined with a caregiver support app, can reduce neglect in older adults with dementia. Researchers will compare three groups: one receiving screening alone, one receiving screening plus the SIRENS app, and on…

This trial explores whether a single dose of psilocybin, combined with motivational support therapy, can help people with HIV who have moderate-to-severe methamphetamine use disorder reduce or stop their meth use. Participants will be randomly assigned to receive either a higher …

This study explores whether robot-guided repetitive transcranial magnetic stimulation (rTMS) can effectively treat postpartum depression (PPD). Researchers will compare brain activity, heart signals, blood markers, and body awareness in women with PPD versus healthy controls. Par…

This trial tests a blended caregiver-led intervention for autistic toddlers under 3, combining social-communication strategies with social-emotional support. Caregivers are coached over 12 weekly sessions to embed these techniques into daily routines and play. The study aims to s…

This study tests whether a short couples therapy, called MERA-C, can help reduce intimate partner violence and improve emotional health in veteran couples. The therapy involves four weekly sessions with both partners, focusing on managing emotions to prevent aggression. Researche…

This trial tests whether a text message-based program called Text2Quit-Kenya can help current tobacco users who visit the emergency department at Kenyatta National Hospital in Kenya quit smoking. Participants receive automated, interactive texts timed around their quit date to tr…

This trial tests a medical device that has not yet been approved by the U.S. FDA. The goal is to see if it can help control a specific disease. Participants will use the device as directed, and researchers will monitor its effects on symptoms and disease progression.

This trial explores whether personalized brain imaging can predict who responds best to three rapid-acting treatments for suicidal ideation in people with depression or PTSD. Participants receive either real-time brain feedback (neurofeedback), a form of magnetic brain stimulatio…

This trial tests whether an individually tailored form of behavioral activation therapy can help people who use drugs after release from incarceration. Participants receive 12 therapy sessions over 8 weeks, integrated into a reentry primary care program with peer support. The stu…

This trial tests whether home-based virtual reality cognitive exercises, done on a tablet, can help slow mental decline in people with mild-to-moderate Alzheimer's disease. Some participants will also have online sessions with a neuropsychologist. The study aims to find a practic…

This trial tests whether a brain-training technique called neurofeedback can help people with crack cocaine use disorder improve their self-control and reduce cravings. Participants in residential treatment will receive either standard care alone or standard care plus up to 30 se…

This study tests a program that provides overdose education and naloxone (a drug that reverses opioid overdoses) to homeless veterans at risk. The program is being rolled out at VA sites that serve veterans in supportive housing. Researchers will measure how well sites adopt the …

This trial tests whether the schedule of maintenance transcranial magnetic stimulation (rTMS) affects the risk of depression relapse. Adults who responded to an initial course of theta burst stimulation are randomly assigned to receive 20 maintenance sessions either clustered tog…

This trial tests a 12-week home-based program called SPRINT for infants aged 7-15 months who were born preterm or have a family history of conditions like ADHD, autism, or developmental delay. Parents use an app to guide daily play activities aimed at improving parenting skills a…

This study tests a program called Abstinence Reinforcement Therapy (ART+) to help veterans who are homeless quit smoking. The program combines telehealth counseling, nicotine replacement therapy, and financial rewards for staying smoke-free. Researchers will compare ART+ to stand…

This trial tests a 24-week virtual care program called BRIDGE NET for people with serious mental illness who are starting cancer treatment. The program brings together oncology and mental health teams to plan care, provide early psychiatric support, and regularly check in with pa…

This study tests whether a robotic surgical system can safely perform delicate microsurgery on deep lymph nodes in the neck of people with Alzheimer's disease. The idea is that improving lymph drainage from the brain might help clear harmful proteins linked to Alzheimer's. The tr…

This study tests whether a counseling program tailored to a person's readiness to change can help gym-goers reduce or stop using anabolic-androgenic steroids (AAS). Participants are randomly assigned to receive either the tailored counseling or standard health education. The goal…

This study tests whether a program called CourtConnect, where peer recovery specialists meet with people in courthouses, can increase substance use disorder treatment and reduce overdose and incarceration. The program provides information, referrals, and up to three months of fol…

This trial tests whether the sleep medication daridorexant can help people with alcohol use disorder and insomnia drink less. Participants take either daridorexant or a placebo nightly for 12 weeks, along with brief counseling. The study tracks alcohol use through self-reports an…

This study explores whether a non-invasive device that stimulates the vagus nerve through the ear can help people with PTSD learn to dampen fear responses. Participants will receive either active or sham stimulation while their body reactions (heart rate, sweat, startle) are meas…

This study tests a fully wireless brain-computer interface (BCI) that aims to decode attempted speech in real time for people with locked-in syndrome (LIS), often caused by ALS or stroke. The implant records brain signals from areas controlling the mouth and throat, then translat…

This trial investigates whether cognitive cycling—a series of structured mental exercises—can help prevent relapse in adults with alcohol use disorder after they complete alcohol withdrawal. Participants are randomly assigned to receive either 12 cognitive cycling sessions over f…

This study tests whether a gentle electrical stimulation of a nerve in the ear (called taVNS) can help people who are dependent on the drug tiletamine. Thirty participants will receive either real or sham stimulation over five days. Researchers will measure changes in cravings, m…

This study tests a small, programmable device implanted in the skull that stimulates the brain's left frontal area to treat depression that hasn't improved with multiple medications. Ten adults with major depressive disorder will receive the implant and be monitored for safety an…

This trial investigates whether pregnenolone, a natural neurosteroid, can help adults who struggle with both cannabis use disorder and major depression. The study involves a small group of 20 participants aged 18 to 50 who use cannabis frequently and want to cut back. Researchers…

This study tests whether brain imaging and clinical data can help select the best treatment for people with depression that hasn't improved with standard therapies. Participants receive either repetitive transcranial magnetic stimulation (rTMS) or ketamine, and researchers check …

This phase 3 trial tests whether viloxazine extended-release capsules, taken once daily, can safely reduce ADHD symptoms in Korean children and adolescents aged 6 to 17. Participants receive either the drug or a placebo for 8 weeks, with doses adjusted based on response. The stud…

About one in four older adults experiences confusion (delirium) after cardiac surgery, which can lead to longer hospital stays and higher risks. This pilot study tests whether using a brain-monitoring device to personalize blood pressure during surgery can help prevent delirium. …

This study compares two approved antipsychotic drugs, risperidone and cariprazine, in 50 adults with bipolar 1 disorder experiencing acute mania. Participants take one of the drugs for 6 weeks, and doctors measure how well symptoms improve using a standard mania rating scale. The…

This study tests a one-time microsurgery that connects lymphatic vessels in the neck to veins, aiming to improve drainage of waste proteins from the brain. Fifty-nine people with severe Alzheimer's will receive the surgery plus standard medication. Researchers will measure change…

This study tests a program that combines executive function training (like planning and problem-solving) with cognitive behavioral social skills training for adults aged 60 and older who have schizophrenia or schizoaffective disorder. Participants attend 42 sessions that teach pr…

This trial tests whether an AI chatbot called MICA, combined with weekly text reminders, can help emergency department patients reduce risky alcohol use. About 750 adults who report heavy drinking will be randomly assigned to use MICA or receive usual care. The study tracks how m…

Autistic children in the emergency department often miss full vital sign checks because standard equipment can be distressing. This pilot study randomizes 100 children aged 2 to 17 to have their heart rate, breathing, oxygen and temperature measured either with wireless wearable …

This study explores whether artificial intelligence can help emergency department doctors identify depression and anxiety in patients. Researchers will record 30 adult patients' facial expressions and voice tones as they read a story, and then use AI to analyze those recordings. …

This study tests a wearable insole and ankle device that measures walking patterns to detect early cognitive decline in older adults. Researchers will collect gait data from 150 participants—some healthy, some with mild cognitive impairment or dementia—first in a lab and then dur…

Researchers are checking whether an Indonesian version of the Oxford Cognitive Screen-Plus accurately measures thinking skills in people who have had a stroke. The study enrolls 75 adults who can read and speak Indonesian and are in the subacute or chronic phase after stroke. Par…

Researchers at Assiut University are studying whether three different tests, a blood marker called GFAP, a brain MRI scan, and a brain wave recording (EEG), can together help doctors tell normal aging, mild cognitive impairment, and dementia apart. The study enrolls 75 adults age…

Researchers at the University of Wisconsin, Madison are testing a decision-support tool that helps primary care providers talk with patients about blood biomarker testing for Alzheimer's disease. The tool is a flowchart that gives clear information about the Phospho-Tau blood tes…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

Researchers are testing a device called the Virtual Eggs Test (VET) to see if it can measure hand dexterity in children and young adults with cerebral palsy or developmental coordination disorder. The test involves carrying fragile objects across a platform without breaking them,…

Researchers are testing an experimental vaccine called AV-1959R in adults aged 55 to 80 who have amyloid buildup in the brain but no memory or thinking problems. The trial compares the vaccine with a placebo to see whether it is safe, triggers an immune response, and lowers brain…

Researchers are testing a behavioral program that sends supportive text messages and offers small rewards to pregnant women who test positive for alcohol, tobacco, or cannabis use in South Africa. The program aims to reduce substance use during pregnancy and breastfeeding, which …

This study tests an 8-week program called KINDER, designed to help family caregivers of people with dementia reduce psychological elder abuse and improve the quality of care. The program includes group discussions over Zoom and a self-paced workbook. Researchers will enroll 260 c…

Researchers at a state hospital in Turkey are testing whether training an entire maternity unit in trauma-informed care changes the experience of childbirth. The program teaches hospital leaders, midwives, nurses, doctors, and support staff to communicate respectfully, protect wo…

This study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…

Researchers at Karolinska Institutet are testing a digital self-help tool called Preventox for patients discharged from intensive care after an intoxication or overdose. The tool lets patients set goals, track substance use, identify high-risk situations, and make a crisis plan. …

Older adults who break a hip and have surgery often develop postoperative delirium, a sudden state of confusion that can slow recovery. Researchers are testing whether adding a small dose of dexmedetomidine to standard spinal anesthesia reduces how often this confusion occurs. In…

Researchers are studying whether community health workers improve mental health among the Wayapi and Teko people in Camopi and Trois-Sauts, French Guiana. These communities face high rates of psychological distress and suicidal behavior. The study tracks suicidal thoughts and att…

This trial tests whether a head-mounted device delivering 40 Hz flickering light and pulsed sound can reduce the risk of postpartum depression in women having elective cesarean sections. Participants receive three 30-minute sessions starting after delivery, with a placebo group r…

This pilot trial tests a two-hour educational workshop called SCREEN, designed to raise awareness of prostate cancer, its symptoms, and the benefits of early screening. The study enrolls men aged 18 to 79 who are not up to date with their prostate cancer screening. Researchers wi…

Researchers are testing a 10-session bilingual therapy program called PrEPared Minds/Mentes PrEParadas. The program uses cognitive behavioral therapy to reduce anxiety and depression in men who have sex with men. The goal is to see if improving mental health helps these men learn…

This trial tests whether an online parenting program, Partners in Parenting, can reduce the risk of depression and anxiety in adolescents aged 12 to 18. Researchers will adapt the program for families in Pakistan and compare it to a teen-focused program and a control group. The s…

This study evaluates a multicomponent care program designed to prevent postoperative delirium in adults aged 65 and older undergoing surgery. The program includes preoperative screening for risk factors like frailty and cognitive impairment, patient and family education, and indi…

This trial tests a support package for Ethiopian women who migrate to the Middle East for domestic work. The package includes peer support, a mobile app with educational materials, self-help groups, and counseling, aiming to improve their mental and sexual health. The study will …

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This trial tests whether a collaborative psychological model—combining daily music listening, a smartphone app with AI chatbot support and mindfulness exercises, telephone check-ins, and wearable monitoring—can reduce the risk of postnatal depression and persistent pain after chi…

This study tests whether an AI-assisted lifestyle program can help adults aged 40 and older without cognitive impairment maintain their memory and thinking skills. Participants receive personalized advice on diet, exercise, mental activities, and social engagement through an onli…

This trial tests whether a brief psychological intervention—combining education, mindfulness, and acceptance-based strategies—can help people who have had a musculoskeletal injury reduce their opioid use and avoid developing chronic pain. The study enrolls adults admitted to the …

This trial tests a program called HADAS, designed to prevent eating disorders and body image dissatisfaction in adolescent female athletes aged 12 to 16 who compete in aesthetic sports like gymnastics and figure skating. The program works with athletes, their coaches, and their f…

This study follows 121 people who carry the APOE-ε4 gene variant and have noticed subtle memory slips—a group at higher risk for Alzheimer's. They previously completed a 12-month program combining diet, exercise, cognitive training, and a green tea extract (EGCG). Now, researcher…

This study tests a 12-week remote program for adults aged 60-75 at risk of cognitive decline. The program includes aerobic exercise, cognitive training, and education on healthy aging, all delivered through a website. Researchers will measure whether the program improves memory, …

This study tests a mobile health app called mSYNC designed to help prevent HIV in people who use drugs and visit the emergency department. The app provides counseling and support for risk behaviors, mental health, and access to care. Researchers want to see if the app is acceptab…

This trial tests a digital app that coaches parents of 5th and 6th graders on how to discourage underage alcohol use. Many parents allow sips, which raises the risk of serious problems later. The study involves 4,000 parent-child pairs and measures teen drinking over time.

This study tests whether a single session of Acceptance and Commitment Therapy (ACT) can help internally displaced adults manage stress and prevent substance use. Researchers will enroll 144 people who have been displaced by conflict and have used at least one substance (other th…

This study tests whether a year-long virtual lifestyle coaching program—focusing on diet, sleep, and activity—can lower Alzheimer's-related blood markers in 1,200 adults aged 60-80 who carry a genetic risk. Participants wear an Oura ring for tracking and provide blood samples. Th…

Researchers are testing whether transcranial magnetic stimulation (TMS) can improve social perception in adolescents with autism spectrum disorder. The trial targets the right posterior superior temporal sulcus, a brain region involved in processing social information. Sixteen pa…

Researchers at Sveti Ivan Psychiatric Hospital are testing whether high-frequency repetitive transcranial magnetic stimulation (rTMS) with the H7 coil reduces gambling disorder symptoms. The trial enrolls 60 men aged 18 to 64 who are starting treatment at a gambling disorder day …

Researchers are studying whether a broad-spectrum oral tincture containing CBD, CBN, and CBG changes anxiety symptoms in adults with generalized anxiety disorder. About 60 participants will take the tincture under the tongue or by mouth roughly every 12 hours for 8 weeks, with fo…

This early-phase trial tests whether giving adults with autism a 6-week course of vancomycin followed by a fecal transplant from a close relative can improve social and language problems. Ten participants will be tracked for changes in autism symptoms, quality of life, and gut he…

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

Researchers at the University of Bergen are testing whether a two-week, self-guided smartphone screen time reduction program can reduce depression symptoms in young adults. The trial enrolls 200 students in Oslo who have sought help at the student mental health service. Participa…

This study tests whether using a person's brain scan (MRI) to guide TMS treatment for depression works better than the standard scalp-measurement method. 160 adults with major depression will receive accelerated TMS (10 sessions a day for 5 days) with either MRI or scalp targetin…

This pilot trial tests whether adding virtual pain neuroscience education to standard spinal cord stimulation can help chronic pain patients better manage their condition. The education teaches how the brain processes pain, aiming to reduce fear, anxiety, and catastrophizing. Par…

This study tests an online self-help tool called e-couch for adults with social anxiety. Over 5 weeks, 200 participants will use the program, which is based on cognitive behavioral therapy. Researchers will use surveys and computer tasks to predict who improves the most.

This Phase 3 trial will test a web-based program called IMPACT for 250 veterans who have both opioid use disorder and chronic pain. The program includes 9 online modules and weekly feedback from a coach, all done from home. The goal is to see if it reduces how much pain interfere…

This study tests two simple activities—volunteering inside the assisted living community or joining a current events discussion group—to see if they can reduce apathy in residents with mild to moderate memory problems. About 200 people aged 55 and older will take part for 6 month…

This study tests whether prucalopride, a drug used for gut issues, can improve thinking and memory in people with schizophrenia. About 34 adults will take the drug for 4 weeks while staying on their usual medications. Researchers will measure changes in memory, attention, and pro…

Researchers test whether adding lumateperone to ongoing antidepressant treatment reduces emotional blunting in adults with major depressive disorder. Emotional blunting means feeling numb or unable to experience pleasure or sadness. Thirty participants who score high on the Oxfor…

This study tests whether brief mindfulness and identity-affirming exercises can improve well-being and reduce mental health symptoms in LGBTQ youth aged 16-26 who are currently or recently unhoused. Two hundred participants will be randomly assigned to either the mindfulness prog…

Researchers at Emory University are studying a modified Argentine tango program called Adaptango for adults with Parkinson's disease, mild cognitive impairment, or dementia, alongside younger adults. Over three months, participants take part in biweekly choreographic sessions tha…

This Phase 2 trial tests whether combining psilocybin—a compound from certain mushrooms—with daily cognitive training can enhance brain plasticity in adults aged 65 and older. Participants include healthy older adults and those with mild cognitive impairment or early-stage Alzhei…

This trial tests whether a traditional Chinese music therapy, called Ziwu Liuzhu Five-Element Music Therapy, can reduce anxiety in people with pancreatic cancer who are undergoing chemotherapy. The study will enroll 320 patients with mild-to-moderate anxiety and randomly assign t…

This study tests whether an 8-week group program teaching dialectical behaviour therapy (DBT) skills is feasible and acceptable for people aged 14–35 who have experienced a first episode of psychosis. The program focuses on managing emotions, tolerating distress, and improving re…

This trial tests whether a brain-training method called decoded neurofeedback, done during MRI scans, can help people with schizophrenia or schizoaffective disorder reduce persistent auditory hallucinations—like hearing voices. Participants are randomly assigned to either the act…

This study tests two therapy approaches to help children aged 3-8 with Avoidant/Restrictive Food Intake Disorder (ARFID) eat more foods and have less stressful mealtimes. One group gets a sensory-based feeding program, another adds coaching for parents, and a third group gets sta…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

This study tests a mobile app called 'Heart Voice: Starry Journey' designed to help parents and caregivers of children with autism feel more flexible and less anxious or depressed. About 52 caregivers will use the app for 6 weeks, doing interactive stories and exercises based on …

This study looks at whether drawing different colors and shapes can help calm adults who are anxious while waiting for surgery. About 175 people scheduled for elective surgery will participate. Researchers will measure their anxiety levels before and after the drawing activity to…

This study tests whether artificial intelligence-supported digital games and exercise activities can improve motor skills, working memory, and brain activity in children aged 6 to 10, both with and without autism. Children in the intervention group will play movement-based digita…

Researchers are studying sleep problems among children aged 4 to 10 in foster care, residential care, and the general population. They will compare sleep and related factors like behavior, parenting stress, and placement history across these groups. The trial also tests a brief b…

This study looks at whether the type of education patients receive about a single propofol sedation session can change how well it works for depression. Twenty adults with moderate to severe major depressive disorder will get one propofol infusion and be randomly assigned to eith…

Researchers at the Medical University of South Carolina are testing a program that adds community health workers to standard trauma recovery services. The study enrolls 100 adult trauma patients who screen positive for PTSD or depression risk and report at least one unmet social …

This trial compares a specially designed needle tip, the Transcodent painless needle, with a standard dental needle to see if it causes less pain during injections in the upper front teeth area. Sixty adults needing dental work on both sides of their mouth will receive injections…

Veterans in outpatient substance use treatment smoke at high rates and often do not get help to quit. Researchers at the VA are testing a program called Co-STOP that pairs nicotine replacement therapy with counseling and delivers it alongside substance use care. The trial enrolls…

Researchers at the University of Michigan are testing a remote program for adults with cannabis use disorder. Participants receive six telemedicine sessions that blend motivational coaching with small incentives for staying engaged. The study compares this approach with enhanced …

This study tests whether a mobile app that combines digital cognitive behavioral therapy (CBT) with personal mental health coaching can reduce anxiety in adults with hearing or mobility disabilities. Participants use either the active program or a sham version for 8 weeks, with f…

This study tests whether a single session of low-intensity focused ultrasound (LIFU) can safely reduce chronic pain and anxiety symptoms. Ten adults with either generalized anxiety disorder or chronic pain will receive multiple ultrasound pulses in one visit and be followed for s…

Researchers are testing whether a group-based acceptance and commitment therapy (ACT) program can improve the psychological well-being and quality of life of parents of children with cerebral palsy. The trial enrolls 76 parents who attend eight weekly 90-minute group sessions led…

Researchers are testing HHK101, an experimental injectable drug, in adults with stable schizophrenia. The trial measures how the body absorbs the drug, tracks side effects, and looks for changes in symptom scores. Participants receive one or more intramuscular injections at diffe…

This Phase 2 trial will test whether taking a daily probiotic supplement for six months is safe and practical for people with early Alzheimer's or those at risk. Researchers will enroll 40 participants aged 60 and older. The study does not test whether the probiotic improves memo…

Researchers are testing whether a handheld device that delivers mild electrical pulses to the ear can be used at home by adults receiving treatment for substance use disorder. Participants use the device for about 60 minutes a day for 30 days. The study measures whether people ca…

This trial tests whether a weekly board game session, held over 12 weeks, can improve thinking and daily living skills in older adults with schizophrenia who live in psychiatric nursing homes. Participants are randomly assigned by group to either the board game program or usual c…

Researchers at Massachusetts General Hospital are testing whether a wearable patch can help autistic teenagers manage anxiety. The patch senses heart rate and guides paced breathing through a phone app, offering practice sessions and prompts during stressful moments. The trial en…

This study looks at whether combining group cardiovascular exercise with group therapy can help reduce symptoms of anxiety and depression in adults living in rural areas. Twenty participants with generalized anxiety or depressive disorders will take part in a structured program. …

This trial compares two short-acting opioids, remifentanil and fentanyl, given during general anesthesia to see which better prevents emergence delirium, a state of confusion and agitation that affects up to 80% of children after surgery. Researchers will enroll 176 children aged…

Researchers are testing whether a five-minute box breathing exercise can reduce pain, anxiety, and breathlessness when a chest tube is removed after open-heart surgery. The trial enrolls 86 adults who have just had heart surgery and still have a chest tube. Half perform 15 cycles…

This trial investigates whether a home-based self-management program called HOBSCOTCH can improve thinking, memory, and quality of life in young adults (ages 18–29) and youth (ages 13–17) with epilepsy. Participants attend nine weekly one-on-one coaching sessions by phone or comp…

Researchers are testing a smartphone app called FobiApp that uses augmented reality to guide people through exposure therapy for cockroach phobia. Adults with a diagnosed cockroach phobia use the app at home, working through increasingly difficult levels that show virtual cockroa…

Researchers are testing two mobile app-based programs, CHAMPS and iCanChange, for young adults with first-episode psychosis who use cannabis. CHAMPS targets safer use for people not looking to quit, while iCanChange supports those who want to reduce or stop. The trial compares ea…

This pilot study tests a smoking cessation approach that combines mindful smoking practice with a smartphone-based sensor-band. Adults who smoke at least five cigarettes a day will be randomly assigned to either receive the mindful smoking intervention plus standard quitting info…

Researchers are testing CROSS-MIND, an eight-week school program where trained teachers lead weekly 90-minute storytelling and reflection sessions for students in grades 6 to 10 in Bharatpur, Nepal. Classes are randomly assigned to the program or to usual school activities, and a…

This clinical trial is testing a non-invasive brain stimulation method called temporal interference transcranial alternating current stimulation (TI-tACS) for people with major depressive disorder or generalized anxiety disorder. The device uses two high-frequency electrical curr…

This study tests a new type of transcranial magnetic stimulation (TMS) that targets three brain areas at once to help with negative symptoms of schizophrenia, like lack of motivation, emotion, or social interest. Researchers will enroll 64 people with first-episode schizophrenia …

Researchers test whether transcutaneous electrical acupoint stimulation, a non-invasive way to stimulate acupuncture points, adds benefit to exposure and response prevention therapy for adults with obsessive-compulsive disorder. The trial enrolls 90 people aged 18 to 50 with mode…

Researchers test whether spending 10 minutes with a trained Judicial Assistance Dog in the waiting room lowers anxiety in child victims of abuse before a forensic interview. The trial enrolls 46 children aged 7 and older who are visiting a child advocacy and pediatric assessment …

Researchers at Peking University are studying a 49-day digital mindfulness program for adults with emotional distress, depression, or anxiety. About 100 participants use a mobile app that delivers daily guided meditations, short lessons on emotions, and practical exercises. The t…

Researchers are testing whether a computer-based model can choose the better add-on medication for older adults with depression that has not improved after at least two standard treatments. The trial enrolls 300 people aged 60 and older who still have moderate to severe symptoms.…

Alcohol withdrawal affects many hospitalized patients and standard sedative treatments have serious side effects. Researchers at the University of Colorado are testing whether intravenous sodium acetate, a natural byproduct of alcohol that the brain can use as fuel, is safe and p…

This pilot study explores whether a personalized telerehabilitation program can help adults who notice cognitive slips in daily life. Participants include older adults and adults with Ehlers-Danlos Syndrome who report subjective cognitive complaints. Over six weeks, they receive …

Researchers at Beijing Normal University are testing whether a guided nature photography program can ease mild depression and anxiety in young adults. Around 300 participants with mild emotional distress will be randomly assigned to take nature photos, take photos of human-made o…

This trial tests two sedatives—remimazolam and dexmedetomidine—to see which better relieves anxiety while keeping pregnant women comfortable and safe during spinal anesthesia placement for scheduled C-sections. The study includes 150 women at full term and measures success by pat…

Researchers are testing whether squeezing a stress ball during femoral arterial sheath removal after coronary angiography can reduce pain and anxiety and improve patient satisfaction. The trial enrolls 34 adults who had a stent or balloon angioplasty through the femoral artery. H…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This trial tests whether progressive muscle relaxation, a technique where you tense and then relax different muscle groups, can lower anxiety in parents who are the primary caregivers of children with cancer. Researchers will randomly assign 112 parents to either join relaxation …

This study compares two drugs, lumateperone and cariprazine, when added to a mood stabilizer for people with bipolar I depression. Researchers will track changes in depression symptoms over 8 weeks using standard rating scales. The goal is to see which drug works better and has f…

This study tests a cannabis plant extract called NTI164, which has very low THC (the compound that causes a high), in 40 females aged 4-25 with Rett syndrome, a rare genetic condition causing severe physical and mental challenges. Participants will receive either NTI164 or a plac…

This study tests whether a full-spectrum cannabis plant extract called NTI164 can help reduce core autism symptoms (like social challenges and repetitive behaviors) in children and young adults aged 6 to 25. About 98 participants will receive either NTI164 or a placebo for 16 wee…

This trial tests whether a single session of deep transcranial magnetic stimulation (dTMS) can reduce food cravings in people with schizophrenia who gained weight from antipsychotic medications. Researchers will compare active stimulation to a sham (placebo) procedure in a crosso…

This trial tests whether brief, video-guided jaw relaxation or breathing exercises can reduce anxiety and fear in children aged 4 to 10 who are having burn dressings changed. Children in a pediatric burn unit will be randomly assigned to one of three groups: jaw relaxation, breat…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce PTSD symptoms in adults who have survived intimate partner violence. 76 participants will receive either a high or low dose and complete weekly th…

This trial tests whether a mobile-guided mindfulness breathing program can reduce symptom distress, fatigue, anxiety, and depression in adults with cancer receiving chemotherapy. Eighty participants will be randomly assigned to either practice 5 to 10 minutes of guided breathing …

Researchers are testing whether an 8-week program that combines virtual reality experiences with educational lessons can help teenagers with major depression. The study will measure changes in depression and anxiety scores using standard questionnaires. Ten adolescents will parti…

This study looks at two methods to control pain after hindfoot surgery: a single nerve block injection versus a small tube (catheter) that delivers numbing medicine continuously for days. The goal is to see which approach reduces pain, cuts down on opioid use, and helps people re…

This trial tests whether six sessions of receptive music therapy, using a specific method called Kigonki, can reduce anxiety in people with advanced cancer who are hospitalized in palliative care units. Participants will be randomly assigned to receive the music therapy or to hav…

This study tests whether a drug called allopregnanolone can reduce depression and pain in veterans who have had a mild traumatic brain injury (TBI). About 132 participants will receive either the drug or a placebo through an IV. Researchers will check symptoms during the infusion…

This trial tests whether an AI-powered support tool, accessed through a WeChat Mini Program, can reduce anxiety in men recently diagnosed with metastatic prostate cancer. Participants are randomly assigned to use the platform with the AI agent or without it for the first two week…

This trial tests whether a structured, one-on-one educational session led by a nurse before an endoscopic retrograde cholangiopancreatography (ERCP) can reduce patient anxiety and improve knowledge about the procedure. Sixty adults scheduled for elective ERCP will be randomly ass…

This trial tests whether a six-week self-guided psychological program can reduce symptoms of body dysmorphic disorder in adolescents aged 15 to 18. Participants with symptoms are split into two groups: one receives the program, the other does not. Researchers compare changes in b…

This trial tests whether wearing virtual reality glasses during double J stent removal can lower patient anxiety and pain. The procedure, common after kidney stone surgery, often causes distress. Researchers will compare patients who use VR distraction with those receiving standa…

This trial tests whether using a weighted blanket during a hospital stay can reduce pain and anxiety in adults recovering from traumatic injuries. Half of the 50 participants will receive a weighted blanket, while the other half gets a standard hospital blanket. Researchers will …

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This pilot study will test whether adding a digital app to group cognitive-behavioral therapy (CBT) helps teens aged 12-17 who have both depression and overweight. Sixty participants will be randomly assigned to either CBT plus the app or CBT alone. The main goal is to see if the…

This pilot trial tests whether a single session of personalized brain stimulation, called PandA-tACS, is safe and tolerable for pregnant women with depression. Researchers will compare it to a standard brain stimulation method and a sham (placebo) to see if it changes brain activ…

This trial tests whether a telehealth program called Babble Boot Camp can improve early communication in babies born very preterm (before 32 weeks). Parents in the treatment group join weekly 15-minute coaching sessions with a speech pathologist for six months, learning activitie…

This study tests a personalized, non-invasive brain stimulation device for 10 people with mild cognitive impairment (MCI). The device uses AI to tailor electrical stimulation to each person's brain patterns while they do memory exercises. The goal is to see if this approach can i…

Researchers are testing whether dance movement therapy can improve social play, emotional regulation, group skills, and communication in children aged 8 to 13 with mild autism. The trial will involve 96 students from special education schools in China, with some classes receiving…

This trial tests whether different electroacupuncture frequencies can ease symptoms of generalized anxiety disorder, a condition marked by persistent, excessive worry. Researchers will compare three stimulation patterns (2 Hz, 100 Hz, and a mixed 2/100 Hz wave) against a sham ver…

Researchers are testing whether a dexmedetomidine nasal spray can reduce anxiety in patients scheduled for brain tumor surgery. Participants receive the spray the night before and the morning of surgery, and their anxiety levels are measured before and after the procedure. The tr…

This trial tests whether an 8-day mindfulness body scan can reduce stress, anxiety, and depression in adults who survived tidal flooding in Sayung, Demak, Indonesia. Participants will practice guided body scan meditation and have their blood tested for inflammation markers before…

This trial tests whether an 8-day mindfulness body scan can reduce stress and inflammation in people who have survived repeated tidal flooding. Researchers will measure blood markers like IL-6, TNF-α, CRP, and cortisol, along with questionnaires on depression, anxiety, sleep, and…

This study tests whether Neuromotor Task Training (NTT) can help autistic children aged 6 to 10 improve a specific motor skill they find difficult in daily life, such as catching a ball or putting on a coat. Each child works with a therapist to practice a chosen skill, with the t…

This trial tests whether combining laughter yoga with virtual reality nature scenes can reduce anxiety and improve sleep in people who are in the early stages of chemotherapy. Participants will either receive this digital behavioral intervention during their chemotherapy infusion…

This study tests whether adding a support person to a trauma-informed cognitive training program helps people with post-traumatic stress improve their daily functioning and reduce distress. The program, called TIGMT, teaches skills like attention, planning, and problem-solving, a…

This study tests a self-help program for 200 post-9/11 veterans who have depression or PTSD symptoms but are not in therapy. The program teaches healthy coping skills and how to find support services. Researchers will compare the self-help group to those receiving standard resour…

This study tests whether a four-week online yoga program, tailored to each teen's physical limits, can lower anxiety in adolescents aged 12 to 18 who are being treated for cancer. Participants either join the yoga sessions or receive no extra intervention, and researchers measure…

This study tests whether a 10-session virtual group psychotherapy program can help people with inflammatory bowel disease (IBD) who also have anxiety or depression. The therapy is adapted from a standard manual called Mind Over Mood and includes education on the brain-gut connect…

This trial tests whether guided imagery, a relaxation technique using audio recordings, can reduce anxiety and improve sleep and comfort in adults with acute coronary syndrome, such as a heart attack, who are in a cardiac intensive care unit. Participants will be randomly assigne…

This study tests two ways to deliver a group training program for caregivers of children with autism in low-resource areas. The program aims to reduce caregiver stress and improve the child's communication and behavior. About 320 caregivers of children aged 2 to 8 will take part.…

This study tests whether a handheld robot that guides meditation with touch and voice can improve sleep quality in older adults with mild memory concerns. 100 participants will either use the robot or a standard meditation app for daily sessions. The goal is to see if the robot h…

This trial tests a digital program called ConCERN for friends and family members of people with opioid use disorder. The program provides educational modules to reduce stigma, improve communication, and help navigate treatment options. Researchers will measure changes in the supp…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This pilot study tests whether psilocybin-assisted psychotherapy is feasible, safe, and potentially helpful for military veterans with treatment-resistant posttraumatic stress disorder (PTSD). Twelve veterans will receive two psilocybin sessions (15 mg and 25 mg) within a structu…

This trial tests a mobile app called Brain CareNotes Latino, paired with remote coaching, for Hispanic caregivers of people with dementia. The app helps create a care plan and tracks symptoms, while coaches offer personalized sessions. Researchers want to see if the intervention …

This pilot study tests a new therapy called Syntactic-Semantic Visual Configuration Intervention (SSVCI) for Urdu-speaking children aged 6 to 12 who struggle to form phrases and sentences. The therapy uses visual cues and structured activities to help children understand and prod…

This trial tests whether having family members write a digital diary during and after a loved one's ICU stay can help them cope with grief. Forty family members of ICU patients receiving life-sustaining treatment will be randomly assigned to either write a diary via WhatsApp or r…

This trial tests whether a coordinated care approach—where doulas provide continuous emotional and physical support and nurse-midwives deliver specialized postpartum care—can improve health outcomes for mothers whose babies are born before 34 weeks and admitted to the NICU. Parti…

This trial tests whether a brief therapy called Written Exposure in Substance Treatment (WEST) can reduce PTSD symptoms in people staying at a residential substance use program. Participants with PTSD are randomly assigned to receive WEST plus usual care or usual care alone. The …

This trial tests whether an online therapy program, supported by peer sessions, can reduce depression symptoms in veterans receiving primary care through the VA. About 400 veterans with moderate depression will either get enhanced usual care or the peer-supported online program. …

This pilot trial tests whether an AI-powered virtual assistant, called VICA, can help family caregivers of people with Alzheimer's disease. The assistant provides education, symptom monitoring, and coaching through conversation. Sixty caregiver-patient pairs will be randomly assi…

This pilot study tests a culturally adapted empowerment self-defense program for Indigenous women (including American Indian, Alaska Native, and Two Spirit individuals) who have experienced sexual violence and currently have moderate to severe depression or PTSD. The program teac…

This trial tests a five-session psychoeducation program designed to help parents of children with ADHD prepare for and cope with disasters. The program covers disaster preparedness, crisis communication, behavior management, emotional regulation, and post-disaster recovery. Resea…

This pilot study explores whether surface-guided radiotherapy (SGRT) can help head and neck cancer patients who feel anxious or claustrophobic during standard radiation treatment. Instead of a tight thermoplastic mask, SGRT uses a camera system to track patient position in real t…

This trial tests whether listening to alpha-frequency binaural beats—a type of auditory stimulation that may promote relaxation—can reduce pain and anxiety after orthodontic separator placement. Participants aged 15-30 with mild crowding will be randomly assigned to either listen…

This study is testing a new group therapy program called CHANGE, designed for young adults aged 18-25 with psychiatric disorders. The program consists of 8 weekly sessions covering topics like transition to adulthood, suicidality, media addiction, and communication. The goal is t…

This trial investigates whether a traditional Chinese medicine formula, Xingqi Daozhi Decoction, can relieve constipation that often occurs as a side effect of antipsychotic medications in people with schizophrenia. The study will enroll 46 adults with schizophrenia who have deve…

This trial tests whether light therapy glasses can reduce depression in people with end-stage kidney disease who undergo hemodialysis three times a week. Participants wear either active glasses (1000 lux) or a sham device (50 lux) for 30 minutes each session over five weeks. The …

This study explores whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help pregnant and postpartum women who have PTSD and a history of substance misuse. Participants receive five weekly telehealth sessions where they write about a traumatic experi…

This study tests whether adults with chronic, stable mental health conditions will actively engage in a 4-month musical immersion program called Résonance(s), which includes rehearsals with a professional orchestra, listening sessions, and a final public concert. The main questio…

This trial tests whether an AI-based system can provide preoperative counseling for elective cesarean delivery as effectively as a physician. Women scheduled for a C-section will be randomly assigned to receive either standard doctor-led counseling or AI-delivered counseling with…

This trial asks whether adding structured exposure exercises to response prevention—a core part of exposure therapy—makes a meaningful difference for people who are highly bothered by persistent physical symptoms. About 360 adults with high symptom burden will be randomly assigne…

Many cancer patients feel anxious before radiotherapy, partly due to unfamiliar equipment and procedures. This trial tests whether adding a simulation-based education session — a virtual preview of the treatment environment — before standard education can reduce that anxiety and …

This trial is testing whether a specially adapted form of cognitive behavioral therapy, called CBT-DAY, can reduce depressive symptoms in autistic youth aged 11 to 17. Participants will be randomly assigned to receive either CBT-DAY or standard care, and researchers will compare …

This study tests a brief psychological program designed to help people who have been hospitalized with a musculoskeletal injury and prescribed opioids. The program includes education about long-term opioid use and mindfulness-based strategies, delivered through a computer session…

This pilot trial tests a structured cognitive rehabilitation program called CanCOG® for cancer survivors who experience thinking difficulties—often called 'chemo brain'—after treatment for cancers outside the brain. Sixty adult survivors will be randomly assigned to either the si…

This study tests whether LEGO®-Based Play Therapy can help children with autism spectrum disorder improve their social and play skills. Children aged 6 to 12 will participate in weekly group sessions for 12 weeks, working together to build LEGO models while taking on roles like E…

This pilot trial tests a digital program called Together in Parenting (TIP) designed to help fathers who are experiencing symptoms of depression or anxiety after their child is born. The program includes short podcasts and educational materials based on interpersonal therapy. The…

This trial tests whether a daily conversation platform powered by artificial intelligence can support cognitive health in older adults at high risk of dementia. Participants engage in voice-based conversations tailored to their interests, designed to exercise memory, attention, l…

This trial tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help cancer survivors and their spouses cope with the fear that cancer might return. It compares ACT to a more traditional therapy, Cognitive Behavioural Therapy (CBT), in a two-arm…

This trial tests a 12-week, physiotherapist-led online exercise program called POSH-Ex for women who recently gave birth. The program combines pelvic floor training, breathing exercises, and whole-body movements to improve sexual function and overall well-being. Researchers will …

This pilot study tests a short brain training program called EEG neurofeedback in adults with alcohol use disorder. Over about one week, participants complete three sessions where scalp sensors record brain activity and provide real-time feedback to help them lower alpha brain wa…

This study tests whether virtual reality (VR) can reduce pain, fear, and distress in children aged 6 to 12 during burn dressing changes. Half of the participants will receive standard care plus VR distraction, while the other half receives standard care alone. Pain, fear, and dis…

This pilot trial tests whether a new short therapy, called Painhunting Therapy, can ease depression symptoms as well as standard cognitive behavioural therapy (CBT) in adults whose depression is linked to a stressful life event. Around 60 adults with depressive symptoms will be r…

This trial tests whether a culturally tailored mobile health program, called Self-Compassion, Health, and Empowerment (SHE), can improve mental health in Chinese immigrant women who have experienced intimate partner violence. Participants receive six weekly sessions covering safe…

This pilot study tests whether playing a collaborative virtual reality game during the first walk after scoliosis surgery can reduce pain and anxiety in teens aged 10 to 17. Half of the participants will use a VR headset to explore a magical jungle with a physiotherapist, while t…

This trial tests whether a 6-week online program delivered via WeChat or WhatsApp can help pregnant women and their partners sleep better and feel less stressed. The program includes videos, quizzes, and professional support. Researchers will measure sleep quality, heart rate, an…

This study tests a mobile health app called OPUCARE designed to support women with infertility who are about to undergo egg retrieval. The app provides medication reminders, treatment information, side-effect tips, and motivational messages. Researchers want to see if using the a…

This randomized trial tests whether adding animal-assisted therapy (AAT) — structured sessions with a trained dog and/or rabbits — to standard rehabilitation can improve motor abilities, independence, and quality of life in older adults with dementia who are hospitalized in a med…

This trial tests whether a smartphone app called LISTEN can help people with brain tumors who have trouble speaking (aphasia) communicate more easily. The app uses artificial intelligence to adapt to each user's needs and can be used with voice input and output. Researchers will …

This trial investigates whether Benson Relaxation Technique (BRT), a 20-minute mind-body relaxation session, can reduce anxiety and depression in people who had an ischemic stroke 1-2 weeks earlier. Participants are randomly assigned to receive either BRT or health education twic…

This trial tests whether listening to white or pink noise through headphones can reduce pain and anxiety in children aged 7–12 during a routine IV insertion. One hundred fifty children will be randomly assigned to hear white noise, pink noise, or receive standard care. Researcher…

This trial tests whether a wearable device that gently stimulates the vagus nerve through the ear can reduce pain and PTSD symptoms in veterans who have both conditions. Participants receive six sessions of a brief PTSD therapy along with either active or sham stimulation over fo…

This trial tests whether a single injection of platelet-rich plasma (PRP), made from a woman's own blood, can reduce pain and improve healing after perineal tears or episiotomies during vaginal birth. About 160 women will receive either PRP or a placebo injection right after deli…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can improve quality of life, reduce fatigue, and clear brain fog in people with long COVID. Twenty adults with persistent fatigue or cognitive problem…

This study investigates whether transcranial magnetic stimulation (TMS) — a non-invasive technique that uses magnetic pulses to stimulate brain areas — can improve thinking, mood, and daily function in people with Alzheimer's disease. Unlike standard TMS, this approach personaliz…

This study investigates whether adding a painless, non-invasive vagus nerve stimulation through the ear to standard physiotherapy can improve motor symptoms and quality of life in people with Functional Neurological Disorder (FND). Researchers will first compare brain function in…

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

This trial tests whether an AI-enhanced mobile app called e-CAMP can improve mental well-being and reduce mild-to-moderate depression and anxiety in young adolescents aged 11 to 15. About 300 students from eight schools in Hong Kong will either use the app regularly for eight wee…

This pilot study explores whether group workshops using MaKey MaKey and Scratch—tools that turn everyday objects into touchpads for creating music, games, and stories—can improve social participation, motivation, and empowerment in adults with mental health conditions. Twenty par…

This trial tests F-GYN, a single-use injectable gel made of non-crosslinked hyaluronic acid, for women with moderate to severe vaginal dryness and atrophy. Participants either receive the injection right away or continue standard non-hormonal care for 4 weeks before getting the i…

This study tests whether changing the environment—by playing relaxing music or dimming the lights—can lower anxiety in adults undergoing a urodynamic study, a test that measures how well the bladder stores and releases urine. About 220 participants with ongoing bladder symptoms w…

This study tests whether virtual reality (VR) and cold packs, alone or together, can reduce pain and anxiety in women after a cesarean section. About 120 women will be randomly assigned to receive VR, cold therapy, both, or standard care. The goal is to see if these drug-free app…

This phase 1 trial tests whether low-energy focused ultrasound can safely and temporarily reduce tics in people with Tourette syndrome. Twenty participants aged 16 and older receive ultrasound to deep brain regions or the motor cortex, or a sham treatment, across four sessions. T…

This study tests whether immersive virtual reality (VR) can lower stress, anxiety, and pain in adults undergoing their first central or midline catheter insertion. Participants use a VR headset showing calming nature scenes during the procedure. The goal is to see if this distrac…

This study tests whether a personalized form of transcranial magnetic stimulation (TMS) can safely reduce behavioral and psychological symptoms in people with Alzheimer's disease. Participants receive either real or sham TMS guided by their own brain network maps. The goal is to …

This study tests a new non-invasive brain stimulation tool called kTMP to treat anhedonia, the loss of interest or pleasure, in people with major depressive disorder. 104 participants will receive either active or sham stimulation. The main goal is to see if kTMP changes brain ac…

This study tests whether using a brain monitor (EEG) during laparoscopic surgery helps patients wake up faster, have less pain, and avoid confusion. 136 adults having elective abdominal surgery will be randomly assigned to groups with or without the monitor, in different surgical…

This trial tests whether a brief email program that helps young adults focus on positive experiences can reduce symptoms of depression and anxiety. One hundred participants aged 18-25 in Zimbabwe will either receive the email program or general mental health information. The stud…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve depression in people with bipolar disorder. Researchers use brain scans to create a personalized map for each participant, targeting the exact brain circuits involved in mood shifts. Parti…

This Phase 3 trial tests whether pramipexole, a dopamine-boosting drug, can ease anhedonia (loss of pleasure) in people with bipolar depression. 126 participants will receive either pramipexole or a placebo alongside their usual mood stabilizer for 6 weeks. The study aims to impr…

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This study tests whether a small device that gently stimulates a nerve in the ear can help reduce depression in people with Parkinson's disease. Participants use the device at home twice a day for 14 days. The trial measures changes in mood and brain activity to see if this simpl…

This study tests whether watching a short educational video before surgery can lower anxiety in adults having elective procedures. Participants are randomly assigned to receive the video via a QR code they scan on their own phone, via a tablet provided in the waiting area, or to …

This study tests whether a structured, midwife-led review of the childbirth experience can improve mental health in new mothers and fathers. The intervention involves a 45-60 minute session where parents discuss their birth story, receive emotional support, and get clarifications…

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This study investigates whether playing 3D motion-sensing games (using Kinect and Google Cardboard) can improve motor control, thinking skills, and quality of life in people with mild to moderate Alzheimer's disease. Participants play specially designed games for 30 minutes a day…

This study tests whether using a virtual reality headset (HypnoVR) during interventional radiology procedures can lower patients' anxiety and pain. Seventy adults will be randomly assigned to either use the VR headset or receive standard care. Researchers will measure anxiety wit…

This study tests whether 12 weekly Qi Gong sessions can reduce dissociative symptoms—like feeling disconnected from yourself or your surroundings—in adults who experienced childhood trauma. Ninety outpatients will be randomly assigned to either add Qi Gong to their usual care or …

This early-stage trial at the University of Chicago tests whether Adderall, a drug used for ADHD, can improve social interactions in people with PTSD. About 40 adults aged 18-65 will receive either Adderall or a placebo and rate their conversations. The goal is to see if this dru…

This study tests whether taking a probiotic supplement called Ecologic® Barrier for 16 weeks can reduce depressive symptoms and change brain activity in adults aged 25-40 with mild-to-moderate depression. Participants will be randomly assigned to receive the probiotic or a placeb…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This trial tests whether a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce inattention in adults with ADHD. Forty adults with ADHD will receive either real or fake tDCS for five days in a row. Researchers will meas…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This study looks at whether aerobic exercise (like brisk walking) and mindful breathing can help adults with major depressive disorder feel better and improve their quality of life. Participants are split into three groups: one does 45 minutes of moderate exercise three times a w…

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

This natural history study will explore how life experiences and environmental factors affect heart health and metabolism among 50 Bhutanese adults living in the US. Participants will complete a survey and discuss their views on providing biological samples. The goal is to identi…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

Researchers at Poitiers University Hospital are studying whether changes in how people with Alzheimer's use their smartphones track with changes in their ability to handle daily tasks. About 100 participants aged 60 and older will have their Android phone usage and battery data c…

This early-stage study tests a new form of transcranial magnetic stimulation (TMS) called high-density theta burst stimulation (hdTBS) in 35 healthy adults aged 22 to 60. The goal is to check if hdTBS is safe and to compare its effects on the brain to standard TMS. Participants w…

Researchers at Emile Muller Hospital in Mulhouse, France, want to estimate how many mothers develop post-traumatic stress disorder after giving birth. About 1,000 women who deliver at the hospital are asked to fill out the City Birth Trauma Scale and a short survey about their he…

Researchers at Assiut University Hospitals are studying how often adults with multiple sclerosis also get primary headaches such as migraine and tension-type headache. About 100 patients will complete a single visit that includes a neurological exam, headache history, disability …

Researchers at Tufts Medical Center are testing an advance care planning program for people 65 and older who have Alzheimer's disease or related dementias, or who face a higher risk of dying within a year. The program pairs participants with counselors and videos that explain car…

Researchers want to know whether caffeine consumption is linked to irregular heartbeats and daily physical activity in adults with heart failure, reduced left ventricular ejection fraction, and an implantable cardioverter-defibrillator (ICD). About 170 participants fill out a one…

Researchers at Chang Gung Memorial Hospital are studying whether an interactive web-based training platform improves how gerontology students handle dementia care decisions. The study first interviews second-year students about the challenges they face when caring for people with…

Researchers at Shanghai Mental Health Center are following 500 people with obsessive-compulsive disorder to see how symptoms, daily functioning, and treatment responses change over time. The study includes adults aged 18 to 60, including some who have never received OCD treatment…

Researchers are studying how four types of brain stimulation for depression, ECT, TMS, VNS, and taVNS, affect decision-making and reward learning over time. About 100 patients receiving these treatments at a German hospital complete repeated online tasks that measure how they lea…

Researchers at Sheba Medical Center are testing whether AI-generated medical summaries help pregnant patients hospitalized for high-risk pregnancies feel more informed and involved in their care. Half of the 200 participants receive up to three AI-written summaries of their medic…

This study looks at how the brains of women with anorexia nervosa respond to fatty food smells and images. Researchers will use brain scans to compare their reactions to those of healthy women. The goal is to understand why fatty foods cause aversion, which could help improve fut…

Researchers at the University of Texas at Dallas are studying how physical activity, sedentary behavior and self-control relate to loss of control eating in children. The study follows 200 children aged 10 to 12 for three years, using brain scans, activity monitors, and real-time…

This study will test a new mobile mental health app designed to help people with schizophrenia or schizoaffective disorder stick to their medication routine. Researchers will enroll 50 adults who are in remission and see if using the app is practical and well-liked. The goal is t…

Researchers are testing an AI-enabled support tool for parents and caregivers of children with autism in Indiana and western Kenya. The tool offers plain-language autism information, answers caregiver questions, supports coping, and helps families find local services, with safety…

Researchers at Assiut University Children's Hospital are comparing children with autism to age- and sex-matched children without it, looking for antenatal, perinatal, and postnatal factors such as parental age, maternal infection, gestational diabetes, birth asphyxia, and family …

Researchers at King's College London are studying what happens in the brain when people hear voices or sounds others cannot hear, known as auditory hallucinations. The study compares people with schizophrenia, schizoaffective disorder, or related psychotic conditions to people wi…

This study looks at how changing the temperature and liquid in e-cigarettes affects the amount of harmful chemicals (oxidants) users breathe in. Researchers will measure markers of cell damage in breath, cheek cells, and blood from 50 adult e-cigarette users. The goal is to under…

Researchers in France ask whether adults treated for substance use disorder also depend more heavily on conversational AI tools. About 100 outpatients at specialized addiction centers fill out one 15-minute questionnaire covering their AI use and their DSM-5 substance use criteri…

This study is testing a program called Mothers and Babies for Down Syndrome (MBDS) to help prevent depression in new and expectant parents of infants with Down syndrome. About 72 parents will take part in a small pilot study to see if the program helps with feelings of grief and …

This project at King's College London asks how hospital outpatient departments can work better for people with neurofibromatosis who also have sensory challenges. About 30 patients, carers, and staff from Guy's and St Thomas' NHS Foundation Trust take part in interviews, observat…

This study compares 200 people with alcohol use disorder to healthy volunteers using questionnaires that measure psychological processes and emotional symptoms like depression and anxiety. The goal is to identify differences in how people think and cope. It is purely observationa…

Researchers at the Medical University of South Carolina are studying whether THC, the main psychoactive compound in cannabis, affects the brain's reward system differently in men and women who use cannabis regularly. About 78 adults aged 21 to 45 who use cannabis at least four da…

Researchers at St. Olavs Hospital are using ultrasound to measure the gluteal muscle in adults who receive depot antipsychotic injections and in healthy volunteers. The study aims to better understand the anatomy relevant to giving these long-acting injections into the buttocks. …

This study aims to create a version of the Mini-Mental State Examination (MMSE) that works better for people in Reunion Island. The current French version has questions that don't fit local culture. Researchers will test 400 people aged 60-89, both healthy and those with Alzheime…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works in people. Participants will be monitored for safety and any effects. The study is still ongoing, and details about who can join are not yet …

Researchers at the National Institute of Mental Health are studying how everyday feelings, like stress or frustration, influence decision-making. They will follow 420 adults aged 18 to 55, including healthy volunteers and people with varying levels of depression, anxiety, or addi…

This study will enroll 400 older adults (over 60) having heart surgery to see if genetic differences affect how well methadone and oxycodone work and their side effects. Researchers will measure pain, nausea, breathing problems, and sedation. The goal is to personalize pain treat…

Researchers at Yale University are using PET brain scans with a radioactive tracer called [11C]OMAR to measure CB1 receptor levels in people with opioid use disorder who are stabilized on buprenorphine, compared to healthy controls. The study aims to see if CB1 receptor availabil…

Children with ADHD often try several medicines before finding one that works well. Researchers are testing PETRA, an online decision-support tool that uses personal data and research evidence to suggest three medication options for each child. The study enrolls children aged 6 to…

Researchers at a Paris children's hospital are studying how children with ADHD decide how much mental effort to put into a task. About 80 children aged 7 to 18 complete behavioral tasks, with and without their usual ADHD treatment, while a computer model estimates their motivatio…

Researchers at the University of Liverpool are exploring how different menu labels affect food choices and feelings in adults with eating disorders, common mental health conditions like anxiety or depression, and no mental health diagnosis. Participants order a meal from a simula…

Researchers at Duke University are studying how natural estrogen changes across the menstrual cycle relate to sleep and ADHD symptoms in girls aged 11 to 15. Participants will wear a Garmin device to track sleep, provide hormone samples, and answer quick surveys about mood and fo…

This study aims to develop and pilot a program for people with HIV in South Africa who also face depression, trauma, and food insecurity. Researchers will first explore how these problems interact, then create a treatment called CBT-SA that combines therapy, nutrition support, an…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study develops and pilot tests a written 'practice companion' designed to help clinicians and other trusted adults provide developmentally appropriate substance use care to youth ages 14 to 24. The companion offers practical guidance on cannabis, opioids, and other substance…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

Researchers are testing whether a light-based imaging technique called near-infrared spectroscopy can measure mitochondrial activity in the brain during bipolar depression. People with bipolar disorder who are depressed will undergo brain imaging before and after treatment with t…

This study interviews adults who have received both electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) for major depression. Researchers want to understand how patients make sense of these treatments and how they fit into their recovery. Participants shar…

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

This study will test ways to improve how doctors choose electroconvulsive therapy (ECT) stimulation settings for people with severe depression or catatonia. Researchers will use real-time brain monitoring to measure brain activity and blood flow during ECT. The goal is to find th…

This trial tests whether practicing mosaic art for six weeks helps midwifery students improve the fine motor skills needed for episiotomy repair, a common procedure after childbirth. Researchers will compare 106 third-year students who do mosaic art before standard training with …

This small pilot study tests a new coaching program where a person recovering from substance use disorder and a loved one each work with their own coach, then meet together as a group. The goal is to see if this approach is feasible and acceptable, and whether it improves recover…

This study compares the immediate effects of inhaling cannabis (either smoked or vaporized) versus tobacco cigarettes on lung health. Researchers will measure breath biomarkers—such as exhaled nitric oxide, volatile organic compounds, and other substances—to see how each substanc…

This study will use brain scans (MEG and MRI) to look at brain activity in 60 young people aged 14-24 who have either attempted suicide, have ongoing suicidal thoughts, or are healthy. The goal is to find brain patterns linked to suicide risk. High-risk participants will also rec…

This study tests whether showing Black and Asian young adults (ages 18–29) the true social norms around depression and suicide can reduce stigma and increase their willingness to seek help. Participants receive personalized feedback that corrects misperceptions about what others …

Researchers at Assiut University are asking whether ADHD symptoms in medical students are linked to depression, anxiety, and lower grades. About 52 undergraduate medical students will fill out questionnaires that screen for adult ADHD, depression, and anxiety. The study also coll…

This study looks at why some older adults experience delirium, a state of confusion, after brain tumor surgery. Researchers will monitor blood pressure and brain wave activity during surgery in 164 patients to see if these factors are linked to postoperative delirium. The goal is…

Researchers at King's College London are studying how the immune system relates to neuropsychiatric symptoms, which include mental and neurological issues. They will compare blood and spinal fluid samples from people with such symptoms against samples from healthy controls. The g…

This study explores whether wearable devices like the Oura Ring and EmbracePlus watch can help track mood changes during pregnancy and after birth. Ten pregnant individuals with a history of major depressive disorder will wear a device daily from the third trimester to three mont…

This study looks at whether certain immune cells (CD8+ T lymphocytes) show different patterns of gene activity in people with bipolar disorder compared to healthy individuals. Researchers will measure markers that help these cells travel to the brain, and they will also check if …

This trial investigates whether activating the body's opioid system with a single dose of morphine influences stress responses and social behavior differently in men and women. It also examines how early life stress may modulate these effects. Healthy adults aged 18-40 will recei…

This study explores whether brain activity and sleep patterns can predict how well people with PTSD respond to Written Exposure Therapy, a brief therapy involving structured writing about a traumatic event. About 200 adults with PTSD will be randomly assigned to either this thera…

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study follows 400 adults with generalized anxiety disorder (GAD) to understand how symptoms and health change over time. Researchers will collect clinical assessments, blood samples, and brain measurements at multiple visits. The goal is to identify factors that may predict …

This study investigates how the brain processes social decisions like trust and cooperation. Participants play a modified trust game, either in an MRI scanner or online, where their choices affect monetary gains or losses. The goal is to link brain activity and behavior to person…

This pilot study explores whether a structured approach called shared decision-making can be successfully implemented in a methadone treatment program. Shared decision-making involves clients and healthcare professionals working together to make treatment choices. The study will …

This trial investigates whether taking lithium for a week changes how the eyes and brain respond to light in healthy adults aged 18 to 40. Participants will undergo light exposure sessions with and without lithium, while researchers measure melatonin suppression, alertness, mood,…

This study explores how financial insecurity—such as trouble paying for housing, food, or healthcare—affects the mental health of university students and whether it keeps them from seeking help. Researchers will conduct in-depth interviews with 30 students from two French univers…

This study follows 200 children and teens aged 7-17 who are at higher risk for depression, anxiety, or obsessive-compulsive disorder (OCD) due to family history or early symptoms. Over two years, researchers will use interviews, questionnaires, brain scans (EEG and MRI), and biol…

This study looks at whether certain proteins in the blood, which signal brain injury, can predict memory and thinking problems in people who survive sepsis or septic shock. Researchers will measure these biomarkers in 210 adults admitted to intensive care and check their cognitiv…

This study aims to develop models that combine clinical assessments with biological data (multi-omics) to improve diagnosis of major depressive disorder and predict how patients will respond to antidepressants. Researchers will follow 150 participants aged 14-45 with depression, …

This study is looking for biological markers in the body that might predict how well people with treatment-resistant psychiatric disorders—like schizophrenia, depression, bipolar disorder, OCD, and catatonia—respond to new treatments. Researchers will collect blood, stool, cerebr…

This study explores whether estrogen influences how the brain processes fear, focusing on postmenopausal women who experience natural declines in the hormone. Participants will take an estradiol tablet and undergo brain scans while viewing shapes that sometimes predict a mild ele…

This lab study tests whether gold nanoparticles can carry lithium directly to brain cells, potentially reducing side effects. Researchers will use neural cells grown from blood samples of people with bipolar disorder and healthy volunteers, plus a mouse model of mania. The goal i…

This study investigates how common depression is among adults who received a liver transplant more than five years ago. Researchers will use questionnaires and interviews to assess mental health and identify factors that may predict depressive symptoms. The goal is to better unde…

This study tests whether 3D infrared body scanning can better assess malnutrition in adolescents and young adults hospitalized with anorexia nervosa. Researchers will measure body composition and track how organ and tissue stores relate to medical stability, nutritional needs, an…

This study uses an anonymous online questionnaire to examine how medical students, midwifery students, and academic hospital staff use substances like alcohol, tobacco, and stimulants, and how these behaviors relate to mental health, stress, and social factors. The goal is to ide…

This study asks whether post-traumatic stress disorder (PTSD) influences how well epilepsy surgery works. Researchers will follow 42 adults with drug-resistant focal epilepsy for two years after surgery, comparing seizure freedom and quality of life between those with and without…

This observational study asks whether a parent can accurately gauge the pain their child feels during a dental local anaesthetic. Children aged 6 to 15 and their parents each rate the child's pain on a 0-10 scale after the procedure. The goal is to see if parents can serve as rel…

This study looks at how depression changes a person's sense of control over events in their life, and whether antidepressant medication can help restore it. Researchers will track 124 adults with depression over 8 weeks of standard SSRI or SNRI treatment, using computer tasks to …

This study follows women aged 70 and older with ovarian cancer to understand why some experience cognitive decline or delirium during treatment. Researchers will track memory, thinking skills, frailty, and quality of life over 12 months, and analyze blood samples for markers of b…

This study looks at the nutritional health of people aged 65 and older who are hospitalized with mental disorders. Researchers will assess conditions like malnutrition, frailty, and obesity, and use the findings to design a practical care pathway for nutritional support. The goal…

This study measures how often depression occurs in adults with alopecia areata, a condition that causes patchy hair loss. Researchers will use a questionnaire to assess depressive symptoms in 100 patients at a dermatology clinic. No treatments or interventions are involved — the …

This observational study tracks how critically ill patients on breathing machines regain consciousness after sedation is reduced or stopped. Researchers will monitor patients for 72 hours to identify different patterns of recovery and see if those patterns relate to outcomes like…

This study follows 500 adults with open limb injuries from drone attacks to understand why some develop severe wound infections. Researchers will collect detailed medical data to link the extent of tissue damage with infection outcomes. The goal is to improve early identification…

This study tests whether coaching prison staff can improve how methadone is provided to incarcerated people with opioid use disorder. Researchers will give individual and group coaching sessions to staff involved in security, medical care, or administration. They will measure cha…

This study follows 2,000 adults with severe mental illness (such as schizophrenia, bipolar disorder, or severe depression) who are admitted to intensive care units (ICUs) in France. Researchers track their survival and other outcomes for up to 12 months to identify factors that p…

This study looks at severely injured adults with multiple traumatic injuries who receive one or more nerve blocks for pain. Researchers want to see if having more blocks improves pain control, reduces opioid use, and helps patients regain mobility faster, or if it increases risks…

This observational study looks at whether snack consumption and eating behavior are linked to the severity of ADHD in children aged 6 to 12. Researchers will survey children with ADHD and a control group about their eating habits and snack choices. The goal is to understand if ce…

This study looks back at the medical records of 300 people with arrhythmogenic cardiomyopathy who have an implantable cardioverter-defibrillator (ICD) and have had dangerous heart rhythms. Researchers want to count how often ICD-related problems occur, such as lead failure or ina…

This study investigates whether sequencing the genomes of patients with early-onset or unusual psychiatric disorders—along with their biological parents—can uncover hidden genetic causes. Researchers aim to find disease-related gene variants in at least 12% of participants aged 3…

This pilot study investigates whether exercising together or separately influences brain function, cognitive performance, mood, and parent-child connection in mother-child pairs. Mothers and their children (ages 4-12) will complete two fitness sessions—one together and one in sep…

This study looks at how exercise affects a natural cell cleanup process called autophagy, which may be linked to depression. Researchers will have 120 healthy adults do a cycling test and take blood samples to measure changes in autophagy and related genes. The goal is to better …

This study looks at whether adding alcohol-related smells to virtual reality scenes makes people with alcohol use disorder feel stronger cravings. Sixty participants will experience different combinations of visual scenes (neutral or alcohol-related) and smells (none or alcohol).…

This study will test 35 people with known or suspected allergies to cannabis, tree nuts, or seeds to see if they are also allergic to hemp seeds. Participants will receive skin prick tests and blood tests to measure allergic reactions. The goal is to understand the potential alle…

The AHEAD study is testing whether artificial intelligence can help detect early signs of Alzheimer's disease in people who feel their memory is slipping but still test normal. Researchers will use brain scans, eye tests, and blood markers to identify those at highest risk. High-…