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Brain scans reveal the hidden mechanics of trust and cooperation

NCT ID NCT07759973

Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study investigates how the brain processes social decisions like trust and cooperation. Participants play a modified trust game, either in an MRI scanner or online, where their choices affect monetary gains or losses. The goal is to link brain activity and behavior to personality traits, such as manipulativeness. By understanding these connections, researchers hope to shed light on social cognition and mental health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Social Learning Task Battery (behavioral tasks including a modified trust game)
What this could lead to
This research could deepen understanding of how brain function drives social behaviors like trust and cooperation, potentially informing future mental health interventions.
What could go wrong
As an observational brain study, it won't directly test a treatment. Results may not translate to real-world social situations, and the large online sample may introduce variability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,612 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Online cohort inclusion criteria: * English fluency * US residency * Owner of a desktop or laptop computer * Adult aged 18-100 Online cohort exclusion criteria: * Participants who have participated in an earlier version of the study * Inability to consent * Self-reported history of neurological disorder or brain damage * Self-endorsed history of psychosis or mania Clinical cohort inclusion criteria: * Adult aged 20-60 years old * English fluency * Owner of a smartphone with celluar data Clinical cohort exclusion criteria: * Inability to consent * Self-reported history of neurological disorder or brain damage * Clinician-rated psychosis or mania in the last 6 months * Current intoxication or withdrawal * Estimated IQ \< 70 * fMRI safety concerns * Pregnancy * Lack of stable psychiatric treatment (e.g., medication dosage, therapy modality) for the previous two months Informant inclusion criteria: * Adult aged 18+ years old * English fluency * Owner of a smartphone with celluar data * Must have 4+ interactions/week with the participant for at least 6 months prior to study baseline Informant exclusion criteria: \- Lack of a smartphone with cellular data at study baseline

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Conditions

The condition(s) this trial relates to.

CGF1 mental disorder personality disorder Personality Disorders Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Interpersonal conflict Mental health Personality disorder Social cognition

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Pittsburgh, Bellefield Towers

    Pittsburgh, Pennsylvania, 15213, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.