Psychiatric disorder

Rett syndrome is a rare genetic disorder that mostly affects girls and stems from mutations in the MECP2 gene. This trial tests GCB-002, an experimental gene therapy given as a single injection into the spinal fluid, in 6 to 9 girls aged 2 to 10 who have a confirmed MECP2 mutatio…

Researchers are following 64 people with cerebral adrenoleukodystrophy (CALD) for 15 years after they received a one-time gene therapy called eli-cel in earlier studies. The therapy uses the patient's own stem cells, modified to carry a working copy of the gene that is faulty in …

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more partici…

This early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…

This study tests whether offering rewards (contingency management) can help people who use methamphetamine reduce their use after a traumatic injury. Twenty adults admitted to the hospital with a positive meth test will receive urine tests and rewards for negative results, starti…

This study tests a 9-session program called MILAP for young married women (ages 15-24) in Nepal who have experienced intimate partner violence. The program involves the woman, her husband, and her mother-in-law, aiming to reduce depression, violence, and PTSD. 900 participants wi…

This study tests whether benfotiamine, a form of vitamin B1, can safely slow memory and thinking decline in people with early Alzheimer's. About 406 adults aged 50-89 with mild symptoms will take the drug or a placebo for up to 72 weeks. Researchers will measure changes in cognit…

This early-phase study tests whether a type of brain stimulation called rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. Participants receive 50 sessions of stimulation over one week. Researchers will measure changes in thi…

This trial tests whether adjusting the number of non-opioid pain pills or adding gabapentin can reduce opioid use after hand, wrist, or elbow surgery. Participants are randomly assigned to one of three pain medication regimens and report their pain levels and any need for extra p…

This study tests whether cannabidiol (CBD) can reduce alcohol cravings and drinking in people with alcohol use disorder. Thirty-six participants will receive both CBD and a placebo at different times to compare effects. The goal is to see if CBD can help control alcohol use, but …

This study tests whether offering small monetary rewards can help people with opioid and stimulant use disorders stay in treatment and avoid drug use. Fifty-six adults starting medication for opioid use disorder at a family medicine clinic will earn incentives for attending appoi…

This study tests whether a drug that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel less craving. About 184 adults who want to cut back or quit drinking will take the drug or a placebo and report their drinking and cravings. The goal is to …

This study tests an experimental drug called RO7126209 (Trontinemab) in people with early to moderate Alzheimer's disease. The drug is given by IV infusion and aims to reduce amyloid plaques in the brain, a hallmark of Alzheimer's. About 241 participants will receive either the d…

This study looks at two different sedative medicines given to children on breathing machines in the ICU. The goal is to see which one causes less confusion (delirium) and helps the brain recover better. About 372 children up to age 11 will take part. The results could change how …

This study tests two approaches—lifestyle medicine consultations and cognitive behavioral therapy (CBT)—to reduce cardiovascular risk in autistic individuals aged 9 to 26 who have a high body mass index. Participants are randomly assigned to receive lifestyle coaching, CBT sessio…

This small pilot study at Yale tests whether semaglutide (a drug used for diabetes and weight loss) can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take the drug for three months and be followed for three more months to s…

This trial investigates whether drinking a beverage made from 30 different organic vegetables daily for four weeks can improve gut microbiome diversity, reduce inflammation, and ease PTSD symptoms in adults diagnosed with PTSD. Participants are randomly assigned to receive either…

This early-stage study tests a new drug called RO7812653 in 50 people with early Alzheimer's disease. The main goal is to check if the drug is safe and how the body handles it. Participants receive a single dose injected into the spine and are closely monitored for side effects.

This study tests a vaccine called AADvac1, which targets tau tangles in the brain, a hallmark of Alzheimer's. It will be given alone or with another drug (donanemab) to 450 adults aged 50-80 with very early Alzheimer's. The goal is to see if this approach can reduce tau buildup a…

This study tests whether a probiotic called Lactobacillus plantarum can improve social interactions, reduce inflammation, and enhance quality of life in adults with autism spectrum disorder. Twelve participants take the probiotic for 8 weeks, with assessments including blood test…

This study tests whether giving buprenorphine (a medication for opioid addiction) through telemedicine works as well as in-person care. Fifty adults with opioid use disorder will be randomly assigned to either remote or in-person treatment. The main goal is to see how long people…

This trial tests whether an 8-week home-based program called FEED@Home can reduce hospital readmissions for people with advanced dementia who have feeding difficulties. The program involves speech therapists and nurses guiding family caregivers through teleconsultations and home …

This Phase 3 trial is evaluating how safe solriamfetol is when taken daily over a long period by children and adolescents with ADHD. Participants who completed earlier studies will receive the medication and be monitored for side effects. The goal is to see if this treatment rema…

This trial tests whether extra support from peer recovery specialists can help young adults aged 18 to 25 stay in outpatient substance use treatment. Participants receive four weekly sessions plus monthly check-ins focused on motivation and skills to improve attendance. Researche…

Researchers are testing a digital program called Centering Appetite in African American adults with type 2 diabetes and binge eating. The program includes web-based lessons to help people relearn their body's hunger and fullness signals, along with diabetes education and a Fitbit…

This study tests whether a smoking cessation medication (varenicline) combined with tools to help people stick with treatment can improve quit rates for smokers living with HIV. About 340 participants will be followed for 6 months to see if they stop smoking, confirmed by breath …

This study is testing the long-term safety and effectiveness of a drug called TSND-201 for adults with PTSD. Participants who completed an earlier blinded trial of TSND-201 can receive up to three treatment courses over 48 weeks, each consisting of four weekly doses. The goal is …

This study tests whether a personalized letter and proactive phone calls can help veterans with a newly diagnosed lung nodule quit smoking. The program uses the diagnosis as a 'teachable moment' to motivate quitting. Researchers will compare how many veterans use cessation servic…

This study looks at the long-term safety and effectiveness of azetukalner in adults with major depressive disorder. Participants must have successfully completed a previous phase 3 study of this drug. The goal is to monitor side effects and track changes in depression symptoms ov…

This trial tests whether low intensity focused ultrasound (LIFU), a non-invasive technique that uses sound waves to stimulate deep brain regions, can safely ease symptoms of obsessive-compulsive disorder (OCD). Researchers will target the ventral striatum, an area linked to OCD, …

This trial tests whether allowing adults in Basel to buy cannabis from pharmacies, instead of the illegal market, changes how much they use and their mental and physical health. About 374 adults who use cannabis at least monthly will be randomly assigned to either regulated pharm…

This trial tests an adaptive deep brain stimulation system for people with severe obsessive-compulsive disorder (OCD) that has not improved with standard treatments. The device, implanted in the brain, aims to detect brain signals linked to OCD distress and adjust its stimulation…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with alcohol use disorder drink less. About 80 adults will receive either the drug or a placebo shot weekly for 5 months. Researchers will measure changes in drinking, brain activity, …

This Phase 3 study tests the long-term safety and effectiveness of azetukalner, a daily pill, in 400 adults with bipolar I or II depression who previously completed a related study. Participants take the drug for 52 weeks, and researchers track side effects, mood changes, and qua…

This trial tests whether quitting tobacco for 7 days or 21 days changes how much cannabis people choose to smoke. Adults aged 18 to 60 who use both cannabis and tobacco will be randomly assigned to one of two tobacco cessation periods. Researchers will then measure how many canna…

This study tests a program called Mastering the World of Work (MWW) designed to help people with serious mental illness improve their job outcomes. The program focuses on building metacognitive skills — the ability to understand one's own thoughts and others' perspectives — throu…

This study tests whether deep brain stimulation (DBS) can improve thinking and memory in people with early Alzheimer's disease. Two participants will have electrodes implanted in a brain area that produces a key chemical for memory. The goal is to see if daily, one-hour stimulati…

This study tests a new approach to help people recovering from opioid use disorder avoid relapse. About 90% of people in treatment relapse within a year. Researchers will use a gentle, non-invasive brain stimulation method called tDCS combined with cognitive training to see if it…

This study tests whether a gentle electrical current applied to a brain area involved in fullness can reduce food intake and promote weight loss. Over 4 weeks, 148 obese adults will receive either real or fake stimulation while following a reduced-calorie diet. The goal is to see…

This trial tests whether a dietary supplement called NVP-NK4146 can improve memory and thinking in older adults with mild cognitive impairment due to Alzheimer's disease. Participants aged 60 and older will take the supplement or a placebo twice daily for 36 weeks. Researchers wi…

This study tests different medication and counseling combinations to improve how long people stay in treatment for opioid use disorder and whether they can safely stop medication without relapsing. Over 1,500 participants choose either buprenorphine or naltrexone and are randomly…

This study tests a brief computerized and smartphone-based program designed to help regular cannabis users with Cannabis Use Disorder better handle emotional stress. The goal is to see if the intervention reduces distress intolerance and cannabis use compared to a health educatio…

This phase 2 trial tests whether psilocybin, the active compound in magic mushrooms, combined with psychotherapy can help adults with moderate to severe cannabis use disorder reduce or stop their cannabis use. Participants receive two doses of psilocybin alongside motivational en…

This study tests a new medicine called ONO-2020 in 240 people with mild to moderate Alzheimer's disease. The goal is to see if it can safely improve memory and thinking skills. Participants will receive either the drug or a placebo for 26 weeks, and researchers will track side ef…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people with HIV reduce unhealthy alcohol use and improve their overall health. About 308 participants in Alabama will receive either the combined program or b…

This trial is testing two different forms of repetitive transcranial magnetic stimulation (rTMS) to see which might better ease depression and anxiety in people whose symptoms haven't improved with standard treatments. About 100 adults with treatment-resistant depression will rec…

This trial tests whether a structured improvement strategy, called SAIA, can help syringe service programs in the U.S. deliver more HIV testing and referrals to prevention and treatment services. The study will compare programs using SAIA with those continuing their usual practic…

This study tests whether capsules containing bacteria from healthy people can safely reduce alcohol cravings and drinking in adults with alcohol-related liver disease and cirrhosis. About 80 participants will receive either the bacteria capsules or a placebo, and researchers will…

This study tests whether tirzepatide, a drug approved for weight management, can help people who are obese and have a moderate to severe stimulant use disorder (like methamphetamine or cocaine). Participants receive weekly injections for 20 weeks, along with counseling and brain …

This study follows about 1,756 adults who were part of a larger trial and received either ketamine or etomidate during emergency intubation. Researchers want to see if ketamine can reduce PTSD symptoms one year later, since it may block the brain's formation of traumatic memories…

This study tests whether giving low-income parents of toddlers with sleep and behavior problems a choice of coaching program leads to better outcomes than being assigned one. Families are randomly placed into one of four groups: sleep coaching, behavior coaching, a choice between…

This study tests a 6-month community-based program that pairs university students with Latinx immigrants and African refugees to provide mutual learning, resource help, and social support. The goal is to see if this approach can reduce psychological distress, financial problems, …

This phase 2 trial is investigating whether psilocybin, the active compound in magic mushrooms, combined with psychological support, is safe and suitable for military veterans and first responders who have both alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). …

This trial investigates whether a long-acting liquid stimulant medication (Quillivant XR) can safely and effectively reduce ADHD symptoms in children with Down syndrome, who are at higher risk for ADHD but often go untreated. The study will compare the medication against a placeb…

This pilot study is testing whether one 25 mg dose of psilocybin, given alongside psychotherapy, can ease depression in people with bipolar II disorder who haven't responded to at least two prior treatments. Using brain scans (fMRI), researchers will look at how the drug affects …

This trial tests an experimental drug called NPI-001 in people aged 50 to 85 with mild cognitive impairment or mild Alzheimer's disease. Participants take either the drug or a placebo as tablets twice daily for 12 months, with doses increasing over time. The study measures safety…

This trial tests whether a culturally adapted program of case manager support can improve survival, reduce hospital readmissions, and boost quality of life for adults recovering from accidental burn injuries in Pakistan. Participants receive up to eight sessions with a case manag…

This trial tests whether giving naloxone — the opioid-overdose reversal drug — just before buprenorphine can help people who use fentanyl start addiction treatment more quickly and with less discomfort. The study enrolls a small group of adults with opioid use disorder who test p…

This study tests whether a telehealth-delivered counseling program, called VetReach, can help veterans with opioid use disorder engage in treatment and improve their outcomes. The program combines motivational interviewing and cognitive behavioral therapy, delivered remotely. Res…

This trial tests whether a personalized training program called 'Kleuter Extra' can improve executive functioning—skills like attention, self-control, and planning—in preschoolers aged 4 to 6 who have severe congenital heart disease. Many children with this condition face thinkin…

This trial investigates whether deep brain stimulation (DBS) — a surgical technique that uses implanted electrodes to regulate brain activity — can be a safe treatment for people with severe, long-lasting anorexia nervosa that has not responded to other therapies. The study will …

This phase 2 trial tests whether low-dose interleukin-2 (IL-2), an immune-modulating drug, can slow cognitive decline in people with early Alzheimer's disease. Forty participants will receive either IL-2 injections or a placebo for several months, and their cognitive function wil…

This study tests whether a digital expert team can help people on long-term sick leave with muscle or common mental health issues return to work. Participants fill out a digital questionnaire and have a video meeting with their doctor and a team of specialists who then create a p…

This phase 3 trial investigates whether bovine colostrum—the nutrient-rich first milk from cows—can improve survival in people with severe alcohol-associated hepatitis. The condition involves liver inflammation, a leaky gut, and a high risk of infection. Participants receive eith…

This study investigates whether intensively lowering systolic blood pressure with FDA-approved medications can reduce the buildup of amyloid and tau proteins in the brain—hallmarks of Alzheimer's disease. The trial enrolls adults aged 60-85 with high blood pressure who are cognit…

This study looks at whether adding a six-session group recovery program and a 90-day home telehealth program can help veterans with substance use disorders drink less and use fewer drugs. About 195 veterans from a VA psychiatric unit will be randomly assigned to one of three grou…

This study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…

This study tests a specially designed psychological treatment module for men in Pakistan who struggle with both depression and substance use disorders. The module combines several therapy approaches and is culturally adapted. Half of the participants receive this 12-session progr…

This trial tests a program that combines motivational interviewing and behavioral couples therapy to reduce intimate partner violence and alcohol use among married couples in South India. Around 800 couples where the wife has experienced violence and the husband has alcohol use d…

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This study investigates whether SGLT2 inhibitors, a class of diabetes medications, can slow cognitive decline in people aged 50 and older with type 2 diabetes. Participants are randomly assigned to receive either standard diabetes care plus an SGLT2 inhibitor (empagliflozin or da…

This study tests whether one or two doses of psilocybin, the active ingredient in magic mushrooms, combined with talk therapy, can help people with treatment-resistant depression. Participants are adults aged 18 to 65 whose depression has not improved with standard treatments. Re…

This study tests whether choline, a vitamin-like nutrient, can improve memory, thinking, and behavior in children aged 2.5 to 5 years with Fetal Alcohol Spectrum Disorders (FASD). Participants receive choline daily for either 3 or 6 months. Researchers measure changes in memory, …

This study tests whether personalized smartphone notifications can improve mood, sleep, and physical activity in medical interns. Participants receive mood, activity, or sleep tips through a mobile app, with the content chosen by a learning algorithm. The goal is to see if these …

This study tests whether a longer, family-involved form of cognitive behavioral therapy (CBT) can work as well as CBT combined with an antidepressant (SSRI) for children and teens with anxiety disorders. Participants aged 7 to 17 with separation, generalized, or social anxiety wi…

This Phase 2 study tests an experimental drug called BIIB080 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease. The drug is injected into the fluid around the spinal cord every 12 or 24 weeks. Researchers want to see if it can slow the worsening…

This study tests whether personalized text messages can motivate people living with HIV in Vietnam to quit smoking. Participants receive motivational texts over six months and are encouraged to use a free government quitline that provides nicotine patches. The goal is to see if t…

This study tests whether a lifestyle physical activity program, supported by a Fitbit and phone counseling, can help women with depression who are in alcohol treatment reduce their risk of relapse. Participants are randomly assigned to either receive the full program or just a Fi…

This study tests whether measurement-based care — where therapists regularly track symptoms using questionnaires — adds extra benefit to weekly psychotherapy for adults with depression or anxiety. Participants are randomly assigned to measurement-based care, standard therapy, or …

This study tests a smoking cessation program called All Nations Breath of Life, designed specifically for American Indian communities. It involves 576 participants at four sites—two on reservations and two in urban areas. The program includes counseling and support, and success i…

This study tests a telephone-based version of the All Nations Breath of Life program, designed specifically for American Indians who smoke. Participants receive coaching calls over the phone and are compared to those in a general smoking cessation program. The main goal is to see…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail an…

This phase 2 trial tests whether lamivudine, an antiviral drug, can improve symptoms in people with Rett syndrome, a rare genetic disorder that affects movement, communication, and behavior. Ten participants will take the drug by mouth for a set period, and researchers will measu…

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This study planned to test the drug bumetanide in children aged 5 to 17 with autism of known cause. The goal was to see if it could improve autism symptoms. However, the trial was withdrawn before enrolling any participants, so no new information was gathered.

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether ibudilast, an anti-inflammatory drug used in Japan, can help people with alcohol use disorder drink less. Fifty adults will take either ibudilast or a placebo for 6 weeks, plus counseling. The main goal is to see if it reduces the number of heavy drinking…

This study compares a new blended therapy (online sessions plus in-person visits) to standard in-person therapy for teens with conduct disorder or antisocial behavior. Researchers want to see if the blended approach works just as well at reducing aggression, delinquency, and out-…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with schizophrenia who are overweight or obese and did not lose weight on metformin. About 92 participants will receive either semaglutide or a placebo. The main goal is to see if sema…

This phase 2 trial tests whether a combination of intravenous immunoglobulin (IVIG) and rituximab can help people with psychosis caused by antibodies attacking the brain. 70 participants with acute psychosis and specific antibodies receive either the immunotherapy or a placebo. T…

This study aimed to test whether electronic cigarettes could help people with schizophrenia quit or reduce smoking. It planned to enroll smokers with schizophrenia from Sicily and compare e-cigarettes with nicotine, without nicotine, and a nicotine-free inhaler. However, the tria…

This study tests a guided internet-based treatment program called eBA for people with harmful alcohol use. Participants complete 9 online modules over 8-12 weeks, with therapist support. The goal is to see if the program reduces drinking and improves mental health and quality of …

This study tests whether adding culturally-aligned activities and healing groups to standard medication-assisted treatment (MAT) helps people with opioid use disorder stay in treatment longer and reduce harm. About 136 adults newly enrolled in the Cherokee Nation MAT program will…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This study tests whether a structured parent training program can reduce autism symptoms in children up to age 5 and high-risk infants under 2. 250 children and their caregivers will be randomly assigned to receive either the training plus routine care, or routine care alone. Aft…

This study looks at whether offering money can help hospitalized smokers quit. Over 1,000 adult smokers will be given different types of financial rewards to see which approach works best. The goal is to find a cost-effective way to help people stop smoking for good.

This study tests whether semaglutide (Wegovy), a weekly injection for weight loss, can help people in secure mental health care who have gained weight from antipsychotic drugs like clozapine or olanzapine. About 20 adults with a BMI of 35 or higher will receive the drug along wit…

This study tests whether a mix of treatments—including the patient's own stem cells, a strict keto diet, and a fecal transplant—can improve social skills, communication, and gut health in 50 teens and adults with autism. Participants must be stable on their current medications. T…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests whether combining online sessions with in-person therapy helps people with alcohol use disorder stay in treatment longer and drink less. About 1800 adults seeking public alcohol treatment in Denmark will take part. The goal is to see if this blended approach work…

This study tests whether a 6-week exercise program, done twice a week, can improve physical and mental health in 100 adults with severe mental illness. Participants are randomly assigned to either usual care or usual care plus the exercise program. The goal is to see if exercise …

This phase 2 trial tests whether rituximab, an anti-inflammatory drug used for conditions like multiple sclerosis, can improve symptoms in adults with schizophrenia spectrum disorders. About 123 participants aged 18-55 will receive rituximab or a placebo added to their usual trea…

This study tests whether regular warm-water baths can improve blood sugar control and brain energy use in healthy adults aged 65 and older who are at risk for Alzheimer's disease. Over 10 weeks, 60 participants will soak in warm water three times a week. Researchers will measure …

This study tested a new approach for people with severe depression that hasn't improved with other treatments. A small wire was placed on the surface of the brain to send gentle electrical pulses to areas that control mood. The goal was to see if this is safe and could help reduc…

This study tests whether a 90-day Mediterranean diet can lower drug cravings and improve blood health in people being treated for opioid addiction with methadone or buprenorphine. Forty adults will either follow the diet or eat as usual. The goal is to see if better nutrition can…

Functional somatic disorders cause persistent physical symptoms that doctors cannot explain by other diseases. The DISTRESS trial evaluates a new clinic where internal medicine doctors, trained to recognize these disorders, examine patients and provide guidance to their general p…

This study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…

This trial tests an experimental imaging tracer called [11C]-CS1P1, which is designed to attach to a protein involved in brain inflammation. The study will first check the tracer's safety and how it moves through the body in healthy volunteers, then compare its signals in people …

This trial tests whether a sudden, loud hand clap can help doctors quickly tell apart epileptic seizures from psychogenic non-epileptic seizures (PNES), which look similar but have different causes. About 400 people undergoing video-EEG monitoring will receive the clap test durin…

This early-phase study tests whether a single injection of pramlintide, a diabetes drug, can temporarily increase levels of Alzheimer's-related proteins in the blood, potentially revealing early signs of the disease. Researchers will measure changes in beta-amyloid and tau protei…

Stanford University is developing a mobile app that uses video of a simple physical test (the Short Physical Performance Battery) to assess physical and cognitive function in older adults. The study will collect video data from 30 healthy volunteers to train the app's AI. The goa…

This study tests whether adding a communication skills video and a substance use module to standard couples HIV testing can help male couples reduce drug use and risky sex. About 484 male couples are randomly assigned to receive standard testing alone or with one or both extra mo…

This trial tests a school-based program called HENKA, designed to promote emotional well-being and prevent mental health problems in adolescents aged 12 to 16. The program includes eight classroom sessions on skills like self-esteem, emotional regulation, and mindfulness, taught …

This study looks at how to best help HIV clinics in Vietnam offer a short alcohol counseling program to patients who drink heavily. The goal is to reduce risky drinking and lower the chance of spreading HIV. Over 3,200 people living with HIV and clinic staff are taking part to se…

Researchers are testing whether ParentText, a WhatsApp-based parenting programme, can be delivered through government health services in South Africa's Western Cape. The programme has two five-lesson modules: one on improving caregiver-child relationships and one on keeping child…

Researchers are testing whether a detailed functional exam plus motivational interviewing helps physically inactive 40-year-olds become more active. Half of the 250 participants receive a full functional profile with advice and goal-setting support; the other half get standard me…

Researchers are testing a 12-month physical activity program for adolescents with overweight. The program includes weekly 90-minute sessions with strength, endurance, and coordination training, plus a small-group session with peers. The study measures changes in fitness, strength…

This trial tests whether 5-10 minutes of daily mindfulness and compassion training in school can prevent anxiety and depression in children aged 6-16. About 1,750 pupils will take part, with some classes doing the training for 10 weeks and others not. Researchers will track menta…

This pilot trial tests whether a group workshop called the Body Image Program (BIP) can help prevent eating disorders in female university students in Mexico. Thirty participants will attend two weekly sessions with exercises to challenge societal pressure to be thin. Researchers…

This study tests whether combining aerobic exercise with cognitive training, delivered via interactive 'exergames' at home, can help prevent Alzheimer's in older adults who have memory concerns but no diagnosed dementia. Participants will be randomly assigned to either an exergam…

This study looks at how lifestyle habits affect memory and thinking in older Singaporeans aged 60-75. Researchers will test a program that promotes brain-healthy behaviors, focusing on common issues in this group. The goal is to see if these changes can slow down cognitive declin…

This trial tests whether a specific type of computerized cognitive training, called speed-of-processing training, can delay the onset of mild cognitive impairment or dementia in adults aged 65 and older. Participants will complete 45 sessions of either the training or a general c…

This trial tests whether a structured prevention bundle can reduce delirium in adults aged 70 and older admitted to a cardiac intensive care unit (CICU). Participants are randomly assigned to either usual care or the bundle, which includes daily pain checks, avoiding sedatives wh…

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with P…

This trial asks whether the type of pain relief a woman receives during labor can influence her risk of developing postnatal depression. About 10-15% of new mothers experience postnatal depression, and this study compares epidural analgesia with non-epidural options like laughing…

This trial tests whether combining a diabetes drug (metformin) with an intensive lifestyle program—including diet, exercise, brain training, and health monitoring—can prevent cognitive decline in older adults at risk for dementia. Six hundred participants aged 60-79 with risk fac…

This trial tests whether a combination of lifestyle interventions—brain training, yoga, music therapy, and a special diet—can slow or reverse early signs of neurological disorders like dementia, stroke, epilepsy, and Parkinson's disease. Participants are healthy adults aged 50 an…

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study tests two different programs designed to prevent depression in teenagers who are at risk. One program is an online course called CATCH-IT, and the other is an 8-session group program called TEAMS. About 636 teens aged 13-19 with mild depressive symptoms but no current …

This study compares two ways to sedate ICU patients who need a breathing machine: inhaled sedation (using isoflurane gas) versus standard intravenous (IV) sedation. The goal is to see if the inhaled approach reduces the chance of delirium—a state of confusion that often occurs in…

This study tests whether a short, modified exposure therapy given soon after rape can prevent post-traumatic stress disorder (PTSD) in women. About 166 women who have experienced sexual assault will be randomly assigned to either the brief therapy or standard care. The goal is to…

This study tests a 9-month mentoring program for 8th and 9th graders who have experienced child abuse or neglect and are involved with child welfare. The program pairs teens with graduate student mentors who help them set goals in relationships, education, activities, career, and…

This study tests a digital program called BrotherlyACT designed for young Black males aged 15-24 who have experienced trauma. The program includes life skills coaching, safety planning, and an AI chatbot to help reduce violence and substance use. 300 participants will be split in…

This trial tests a school-based program called PreVenture, which uses brief workshops tailored to teens' personality traits to prevent substance use disorders. Over 12,500 students across Canada are taking part. The goal is to see if this approach can delay or reduce drug and alc…

This study tests a program called Journey of Transformation for Native American tenth graders at an off-reservation boarding school. The program uses traditional storytelling, cultural arts, and outdoor activities to teach leadership and healthy decision-making around substance u…

This pilot study tests whether a smartphone app called AmDTx can help lung cancer patients manage anxiety before and after surgery. The app includes mindfulness training and a relaxing puzzle game. Only 6 participants are enrolled, and the main goal is to see if people will actua…

This study tests whether adding cognitive training to balance and gait exercises helps people with Parkinson's disease improve their balance, walking, and thinking. Fourteen participants will undergo 12 sessions of combined training. The goal is to see if this approach eases move…

This study tests a program called Healthy ReStart that uses health coaching, motivational interviewing, and online tools to help adults with serious mental illness return to active lives after major disruptions like the COVID-19 pandemic. Sixty participants will receive either th…

This study looks at whether medical hypnosis can help reduce anxiety in people with solid tumors who are getting radiation therapy. About 45 moderately to very anxious patients will either listen to relaxing music alone or combine it with hypnosis during their sessions. The goal …

This study tests whether berberine, a natural compound, can safely improve negative symptoms of schizophrenia—like low motivation and emotion—that current medications often miss. Researchers will give berberine or a placebo to 120 Han Chinese adults with stable schizophrenia and …

This study looks at whether weekly phone counseling can help identify and treat depression in women with ovarian, peritoneal, or fallopian tube cancer. About 409 participants will either receive phone counseling or standard care with resource lists. The goal is to see which appro…

This study tests a small device called Cerogrin that gently stimulates a nerve in the ear, aiming to improve thinking and memory in people with vascular dementia or mild cognitive impairment. Twenty-four participants will use the device at home for 30 minutes daily over four week…

This study tests a virtual behavioral therapy (Functional Behavioral Training) for children aged 2-12 with genetic syndromes like Fragile X, Angelman, or Rett syndrome who have challenging behaviors. The therapy teaches parents how to identify what triggers problem behaviors and …

Researchers at Cambridge Health Alliance are adapting a mental health screening and support program for racially, ethnically, and linguistically diverse youth aged 12 to 17 in the Denver Health area. The program includes screening, feedback, a single session intervention, and res…

This study tests a computer-based memory strategy program called E-MinD Life in 60 older adults, including healthy individuals, those with memory complaints, and those with mild cognitive impairment. The program teaches memory strategies through daily activities over 9 weeks. The…

People on hemodialysis receive needle sticks through a fistula or graft several times a week, and the pain and anxiety can build over time. This trial tests whether slow, deep breathing combined with lemongrass aromatherapy reduces pain and anxiety during needle insertion. Resear…

Researchers are testing whether a Joovv Mini infrared light device changes mood, sleep, and activity levels during winter months. Participants include US-based adults with a history of mental health issues such as depression who live in colder regions. They will use the device an…

This study adapts Project YES+, a behavioral program, to improve mental health and reduce HIV-related stigma for adolescent and young men who have sex with men living with HIV in Vietnam. Eighty participants aged 16-24 will receive individual and group sessions with peer mentors.…

Researchers are testing a personalized, non-drug treatment for adults with ongoing depression, anxiety, trauma-related symptoms, sleep problems, attention difficulties, or substance-use concerns. Instead of assigning treatment by diagnosis alone, the study selects approaches base…

This study tests whether a therapist-guided virtual reality (VR) program can help adolescents in psychiatric hospitals improve how they regulate their emotions. Participants, aged 11 to 18, are randomly assigned to either personalized VR exposure sessions or a VR relaxation contr…

This study tests a cognitive behavioral therapy (CBT) group designed specifically for women Veterans who have alcohol use disorder. About 162 women will take part, and the therapy focuses on changing drinking habits and related behaviors. The goal is to see if this female-only ap…

This study tests whether masupirdine, a daily tablet, can safely reduce agitation in people with Alzheimer's dementia. About 375 participants will receive either masupirdine or a placebo. The main goal is to see if the drug improves agitation symptoms, which can include aggressio…

This study aims to develop and test a shortened version of Mindfulness-Based Cognitive Therapy (MBCT) to improve mood in older African American/Black women who have had breast cancer and now have mild to moderate depression. About 23 participants will attend group sessions and re…

This study adapts Written Exposure Therapy (WET), a brief 5-session treatment, for adolescents aged 12-18 with PTSD. Researchers will first gather feedback from experts and teens, then test the adapted therapy against the standard 12-16 session treatment in 48 teens. The goal is …

Researchers are testing whether limiting eating to a 10-hour window each day can improve quality of life, ADHD symptoms, sleep, and gut health in adults with ADHD who have disrupted body clocks. The trial enrolls 60 adults aged 18 to 65 who usually eat over more than 14 hours a d…

Researchers are testing a virtual reality therapy for young people with depression and anxiety. The therapy adapts acceptance and commitment therapy to teach skills for viewing thoughts and emotions as temporary events. Up to 75 young people aged 12 to 25 will receive the clinici…

This study tests whether giving haloperidol alone or with chlorpromazine can safely calm severe agitation and confusion (delirium) in 70 advanced cancer patients in a palliative care unit. The main goal is to see if the drugs improve sedation scores within 24 hours. It is a phase…

Researchers are testing whether occupational therapy that uses virtual reality can improve cognitive skills, daily performance, and motivation in children with autism. The study includes 32 children aged 6 to 12 with autism level 1. Half receive virtual reality-supported cognitiv…

Researchers at the University of Illinois at Chicago are studying which parts of a yoga practice affect anxiety, mood, and thinking in highly anxious college women. About 60 participants complete four sessions that include yoga postures, breathwork, meditation, or watching a yoga…

This study tests a smartphone app called MS CATCH that lets people with multiple sclerosis regularly report their mood to their neurologist. The goal is to improve how doctors screen and treat depression in MS. About 100 adults with MS and mild-to-moderate depression are taking p…

This study tests a new program that combines mindful eating with motivational interviewing to help people with overweight reduce binge eating. One hundred participants will either receive the full program (counseling plus daily meditation) or just daily meditation. The main goal …

This study at Johns Hopkins tests whether using personalized mobile health assessments can improve cognitive-behavioral therapy (CBT) for children aged 8-17 with obsessive-compulsive disorder (OCD). 30 participants will receive either standard CBT or CBT guided by their own sympt…

This study tests whether a smartphone app that uses augmented reality (AR) can help people quit smoking when used alongside standard quitline counseling. The app shows smoking-related cues to help users manage cravings. The trial will enroll 3,600 adult daily smokers and measure …

Researchers are testing a virtual stress-management program for people who care for a spouse or partner with a solid tumor cancer while also holding a job. The program teaches skills such as paced respiration, relaxation, and coping with work and caregiving demands across eight s…

This study looks at whether doing heated or non-heated yoga can reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression. Participants will practice yoga and report their mood changes over time.

This study tests whether a mobile app called PTSD Coach, with or without brief clinician support, can reduce PTSD, anxiety, depression, and sleep problems in World Trade Center responders living in Florida. About 120 English- or Spanish-speaking responders will be randomly assign…

This study tests whether a 12-week web-based support program can improve wellbeing in adults who survived a cardiac arrest 1 to 3 months earlier. The program includes educational modules, videos, breathing exercises, and a chat forum. Researchers will compare 120 participants who…

Researchers are testing whether a six-week group talk therapy program eases depression in Ugandan villages. The trial enrolls about 1,200 people aged 15 and older with at least moderate depressive symptoms across 100 villages in Luuka and Buikwe districts. Villages are randomly a…

Researchers in Greece are testing a nine-session group program called TRANSFORM for people who have finished treatment for blood cancers such as leukemia, lymphoma, and myeloma. The program combines teaching, reflection, coping exercises, and mindfulness to see whether it can spa…

Researchers are testing whether semaglutide, a drug used for diabetes and weight loss, is safe and tolerable in adults with cocaine use disorder. The trial includes 40 people who use cocaine often, some of whom also have HIV. Participants receive weekly injections of semaglutide …

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

Researchers are adapting a mobile health program that pairs the PositiveLinks app with video counseling from a community health worker. The study enrolls 60 people in Florida who have HIV and mild to moderate anxiety or depression. Participants receive either the enhanced counsel…

This study tests a program called FOREST that teaches positive emotion skills to staff working in gun violence prevention. The goal is to reduce burnout, anxiety, and depression, and improve well-being and job retention. One hundred employees from UCAN in Chicago will take part o…

This study combines virtual reality with a gentle electrical pulse on the ear (called taVNS) to help people with chronic shoulder pain who are waiting for surgery. The goal is to see if this drug-free approach can reduce pain, anxiety, and depression. Only 10 people will take par…

Researchers test an 8-week online precision nursing education program for young colorectal cancer survivors. The program includes Qigong exercise and mindfulness training delivered through an e-flipped classroom model. The study measures changes in depression symptoms and mindful…

This study tests whether olanzapine, a medication typically used for mental health conditions, can reduce opioid cravings and misuse in adults with cancer who are on long-term opioid pain therapy. About 87 participants will receive either olanzapine or a placebo to see if it help…

This pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease. Ten participants will work one-on-one with a coach in nine virtual sessions to learn problem-solving strategies and memory a…

Researchers at Baylor College of Medicine are testing whether a supplement combination called GlyNAC can improve brain energy use and reduce inflammation in people with Alzheimer's disease. The trial enrolls 52 adults aged 55 to 85 who have progressive memory loss and amyloid pla…

Depression is common among cancer survivors, but many don't get help. This pilot study tests a text-based referral platform that sends tailored messages and a video to encourage survivors to take up a mental health referral. The study will enroll 60 cancer survivors with depressi…

This study compares cognitive behavioral therapy (CBT) with online expert coaching to usual care for children aged 6-14 with autism who struggle with anxiety, irritability, or emotional outbursts. About 100 children and 50 therapists will take part. The goal is to see if the coac…

Researchers at Evanston Hospital are testing whether a single intramuscular dose of ketamine can quickly reduce suicidal distress in adults who arrive at the emergency department and are waiting for psychiatric admission. The pilot study enrolls 8 patients who receive the injecti…

This study tests a new, non-invasive brain stimulation method using low-intensity ultrasound waves aimed at specific brain areas linked to depression. Researchers will personalize the treatment for each of the 30 participants based on their brain scans. The goal is to see if this…

This study looks at whether terpenes—natural compounds found in plants—can reduce pain when taken alone or with THC. Researchers will test 45 adults who use cannabis regularly to measure pain relief and any feelings of being high or drug liking. The goal is to find safer ways to …

This study is testing a new behavioral program for pregnant women with ADHD. The program teaches skills to manage ADHD symptoms during pregnancy and after the baby is born. Ten participants will work with a therapist in an OB care setting. The goal is to see if the program is acc…

This study tests whether an online problem-solving therapy, matched to a person's specific symptoms using machine learning, can reduce depression and anxiety better than usual care. About 380 adults with moderate symptoms will take part. The goal is to create a precise, scalable …

This study explores whether a photography-based program can help children aged 8-12 with ADHD better recognize and express emotions, and improve attention and impulsivity. Sixty children will take photos and learn photography skills as a tool to boost emotional well-being. The go…

This study looks at whether trained service dogs can help reduce PTSD symptoms in military veterans. 150 veterans who already qualified for a service dog are randomly assigned to receive one or to a waitlist. Researchers track their PTSD severity, depression, and overall well-bei…

This study tests an oral medication called MM120 against a placebo in 245 adults with generalized anxiety disorder. Participants take the drug or placebo for 12 weeks, and those who complete may join a 40-week follow-up where everyone gets the active drug. The goal is to see if M…

This study tests whether a higher dose of a gentle brain-zapping technique called tDCS can safely help people with major depression. About 20 adults will receive mild electrical pulses on their scalp over 5 days. Researchers will check for side effects and see if mood improves.

This study tests a multidisciplinary program for adults with chronic back pain. Participants will attend group sessions on pain education, healthy habits, and emotional coping, plus do therapeutic exercises. The goal is to see if the program improves physical function, reduces fe…

This pilot study tests a live music therapy program called AMUSED for older adults with severe dementia living in care facilities. Participants attend small group sessions twice a week for 12 weeks, either with music therapy or a reading activity. Researchers want to see if music…

This study tests whether a mobile app delivering cognitive behavioral therapy can help U.S. military veterans who have both insomnia and depression. 1,200 participants will receive either therapy for insomnia, depression, or both in sequence. The goal is to see which approach wor…

This study from Yale University will test whether listening to live music can reduce anxiety and improve brain activity in people with early Alzheimer's disease, dementia, or mild cognitive impairment, along with their caregivers. Sixty pairs (patient and caregiver) will attend b…

This early-phase study at Johns Hopkins University is testing whether psilocybin, the active compound in magic mushrooms, can safely help people with obsessive-compulsive disorder (OCD). Thirty-five adults with moderate to severe OCD who have already tried other treatments will r…

This trial tests whether cognitive behavioral therapy (CBT) or mindfulness-based therapy (MBT) reduces post-traumatic stress disorder (PTSD) symptoms more effectively than psychoeducation alone. Female adults who have experienced interpersonal or domestic violence and meet criter…

This trial tests a structured, group-based training program designed to improve executive function skills in elementary school children aged 9 to 12 with autism spectrum disorder. Over 12 weeks, children attend weekly sessions that teach planning, organization, time management, e…

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This study investigates whether breathing a 50:50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain and anxiety during insertion of a central venous catheter, a common but uncomfortable procedure. Adults aged 18 to 65 who have never used nitrous oxide will be randoml…

This study compares two ways to manage pain after total knee replacement: a continuous nerve catheter that delivers numbing medicine for days versus a single nerve block. Sixty-four adults scheduled for knee surgery will be randomly assigned to one of the two methods. Researchers…

This study tests whether a 16-week high-intensity interval training (HIIT) program on a stationary bike can improve thinking, memory, and heart health in women undergoing chemotherapy for breast cancer. Thirty participants will be randomly assigned to either HIIT or a stretching …

This phase 3 study tests whether an oral medication called MM120 can reduce anxiety symptoms in adults with generalized anxiety disorder. About 214 participants will receive either MM120 or a placebo for 12 weeks, followed by a 40-week period where everyone can receive MM120. The…

This study tests whether a special type of sleep therapy, adapted for trauma, can help women veterans with both insomnia and PTSD feel more ready to engage in PTSD treatment. About 100 women veterans will be randomly assigned to either the sleep therapy or a general education pro…

This study compares two low-intensity family treatments for children aged 7-13 with anxiety or obsessive-compulsive disorder (OCD): internet-delivered cognitive behavioral therapy (CBT) and a parent-led reading program. Both are delivered via telehealth and compared to a relaxati…

This study tests a mobile app (CHAMP) that helps parents track their child's feeding progress at home, aiming to make tube weaning easier and faster. About 245 children aged 1 month to 5 years who are ready to stop tube feeding will participate. The app lets parents send feeding …

This study looks at whether a guided therapeutic writing program can help adult women with chronic pain and co-occurring mental health conditions. Participants will complete writing exercises focused on emotional processing and meaning-making over four weeks, then share their exp…

This study tests a communication coaching program for adolescent and young adult cancer survivors (ages 18-35) who have finished treatment at least a year ago. Participants complete online sessions and AI coaching to improve how they talk with peers. The goal is to see if the pro…

This study tests a behavioral sleep and circadian intervention for 50 school-aged children (6–12 years) with autism who have sleep problems. Parents receive 5 Zoom sessions over 12 weeks to learn strategies to improve their child's sleep. The goal is to see if the program is feas…

This trial tests whether a 20-minute session of mandala coloring while listening to slow instrumental music can reduce cancer fear and anxiety in women undergoing cancer screening. Women aged 30 to 65 attending a screening center will be randomly assigned to either the coloring a…

This study tests whether a low-dose extended-release version of levetiracetam (AGB101) can reduce overactivity in the hippocampus, a brain region often overactive in early dementia. Sixty adults aged 50–80 with normal thinking skills will take the drug or a placebo for two weeks …

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This pilot study tests whether a 4-week virtual mindfulness-based group intervention with social support is feasible and acceptable for pregnant individuals at higher risk for substance use. Participants join weekly video conference groups focused on grounding, thinking patterns,…

This study tests whether daily listening to Mozart's Sonata for two pianos in D major (K448) can reduce seizures and improve thinking skills in children with drug-resistant epilepsy. Researchers will compare a group that listens to K448 for 8 minutes each day for 2 months with a …

This study tests whether a drug called MDMA (often known as ecstasy) can boost the effects of a specific type of talk therapy for PTSD in veterans. Twenty veterans will receive one MDMA session along with 12 prolonged exposure therapy sessions. The goal is to see if this combinat…

This trial tests a home-based program called the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) for infants and toddlers with sickle cell disease. The program combines a parenting curriculum with occupational therapy to help families support their child's learn…

This trial tests whether transcranial electrical stimulation (tES) — a safe, non-invasive technique that sends a mild electrical current through the scalp — can reduce pain and improve quality of life in children and adolescents aged 10 to 21 with juvenile fibromyalgia or other n…

This trial tests whether adding a structured psychosocial intervention—sensory and general stimulation plus caregiver education—to standard medication can reduce behavioral and psychological symptoms in older adults hospitalized with dementia or delirium. Participants over 65 wit…

This study compares a 3-session couples program (Brief Relationship Checkup) to standard individual care for 360 veterans and their partners who have relationship and mental health concerns. The goal is to see which approach better reduces suicide risk factors by improving relati…

This phase 2 trial tests whether adding oxytocin nasal spray to standard psychosocial treatment can improve social skills and reduce symptoms in adults with schizophrenia spectrum disorders. Participants receive either oxytocin or a placebo spray alongside their usual therapy. Th…

This study tests a digital tool that helps parents of young children with developmental delays or disabilities organize and share their priorities with early intervention professionals. The tool, called PEM+, is designed to make family-centered care more practical by guiding fami…

This trial tests whether Written Exposure Therapy (WET), a brief six-session therapy involving guided writing about a traumatic event, can reduce PTSD symptoms in adults receiving care at Federally Qualified Health Centers. The study enrolls 720 English- or Spanish-speaking adult…

This trial tests whether heart rate variability biofeedback—a non-invasive technique that teaches people to control their heart rhythm—can ease symptoms of functional neurological disorders (FND), a condition where the brain and nervous system don't function properly despite no s…

This trial tests whether spending time in nature can reduce anxiety in children aged 9-12 who have experienced adverse childhood events. Participants are assigned to either group nature outings, family outings, or a waitlist. The goal is to see if these nature-based activities im…

This study tests whether using a hand extension rubber during IV insertion can reduce pain, anxiety, and improve satisfaction. Researchers will enroll 114 adults who need an IV and randomly assign them to use the rubber or not. The goal is to see if this simple, low-cost distract…

This trial tests a counseling program called Mpata Yathu ('Our Space') for adolescent girls and young women in Zambia who have experienced gender-based violence and may be living with or at risk for HIV. The program uses problem-solving therapy delivered by trained lay counselors…

This study tests whether a 10-week program called Positive Minds, Strong Joints is feasible for Black adults aged 50 and older with knee osteoarthritis. The program combines recommended exercise with mental health strategies to address pain, depression, and anxiety. Researchers w…

This trial tests whether a virtual reality (VR) educational video can reduce anxiety and improve satisfaction in adults starting their first course of external beam radiotherapy for cancer. Half of the 122 participants will watch a VR video through a headset before treatment, whi…

This study tests an online pathway called iPath*D that guides cancer patients who report depression symptoms from screening to treatment options. The goal is to see if the tool is acceptable and easy to use for adults starting cancer treatment. Researchers will measure usability,…

This study tests whether mild electrical stimulation of the ear, combined with physical and speech therapy, can improve symptoms like voice problems, swallowing, and balance in people with Parkinson's disease. 46 participants will receive either active or sham stimulation during …

This study tests an 8-week program that helps people with mild dementia and their caregivers identify and use their strengths. The program includes workshops and a biography activity led by trained volunteers. Researchers will measure changes in thinking skills and caregiver conf…

This trial compares two forms of cognitive-behavioral therapy (CBT) for children and teens with anxiety or obsessive-compulsive disorder (OCD). One approach uses internet-delivered modules with therapist guidance; the other trains parents to lead exposure exercises with their chi…

This trial tests a 12-session cognitive-behavioral therapy designed to help people with substance use who also struggle with anxiety or depression. The therapy focuses on improving emotion regulation—the ability to understand and manage emotions—which may reduce addictive behavio…

People on hemodialysis need their fistula punctured with a needle three times a week, which can be painful and anxiety-provoking. This trial compares three approaches: usual care, applying an ice pack to a specific point on the hand before the needle, and using a numbing gel. Res…

This trial tests a web-based sex and relationship education program called Our Love, Our Style (OLOS) for autistic young adults in South Korea. Participants start with either web-based learning alone or web-based learning plus group coaching. Based on their progress, non-responde…

This pilot study explores whether robot-assisted walking devices can be used in schools to help children who cannot walk independently. The devices attach to a walker and power leg movements, allowing children to stand and walk upright. The study aims to identify the best ways to…

This study tests whether eye-tracking can predict if the drug brexpiprazole will improve symptoms in adults with major depressive disorder. One participant will take brexpiprazole or placebo while researchers measure their visual attention to emotional images. The goal is to see …

This study asks whether standard residential treatment for substance use disorders can improve a person's ability to empathize with others. Researchers will measure empathy levels in about 108 adults before and after they complete a residential program followed by partial hospita…

This study tests whether an 8-week online mindfulness program (MBSR) can improve emotional intelligence and reduce stress-related physical symptoms in adolescents aged 14 to 18 who have experienced bullying and childhood trauma. About 44 teens are randomly assigned to either the …

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for obesity. The app uses strategies from cognitive-behavioral therapy to improve self-regulation and eating habits. Fifty teens will use the app for 16 week…

This trial tests whether an AI-powered chatbot can help reduce anxiety and improve coping in men about to have prostate cancer surgery. Participants will either receive standard preoperative communication or also have access to a large language model (LLM) that answers their ques…

This study tests whether guided meditation delivered through a tablet or virtual reality headset can reduce the risk of delirium in hospitalized adults. Delirium is a sudden state of confusion that can occur during a hospital stay, especially in the ICU. The trial will measure ch…

This study tests whether structured hypnotherapy sessions can improve quality of life for women with breast cancer undergoing chemotherapy. Participants in the intervention group receive 10 hypnotherapy sessions alongside standard care, while the control group receives standard c…

This study explores whether high-intensity interval training (HIIT) is a practical and acceptable treatment for adults with ADHD. Researchers will recruit 30 adults diagnosed with ADHD to participate in a 14-week exercise program combining strength and endurance training. The goa…

This study tests an internet-based cognitive behavioral therapy (CBT) program designed to help autistic adolescents aged 11-17 manage anxiety. The program, called LUNA-Adolescent, is parent-led and delivered online, making it easier for families who cannot access in-person therap…

This study tests whether a device that plays brief, soft sounds during deep sleep can enhance brain wave activity in people with mild cognitive impairment due to Alzheimer's disease. Participants use the device at home each night for three months, with an optional three-month ext…

This study compares a shorter therapy focused on guilt (TrIGR) to a standard PTSD therapy (CPT) in 160 U.S. Veterans. The goal is to see if TrIGR is no less effective at reducing PTSD, depression, and guilt symptoms. Participants are randomly assigned to one of the two treatments…

This study tests whether combining cognitive remediation training (a computer-based program to improve thinking skills) with mild brain stimulation (transcranial direct current stimulation) can help people with severe mental illness who live in supported housing. The goal is to i…

This study tests a new virtual reality program designed to help adults with autism improve their social skills and daily functioning. 140 participants will either receive the VR training plus usual care, or usual care alone, for 3 months. Researchers will measure changes in socia…

This study tests a new method called Strategic Treatment Assessment for Youth (STAY) designed to help racial and ethnic minority teens with depression or suicidal thoughts stay in therapy. Researchers will compare STAY to standard care in 140 teens aged 12-18 across three communi…

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study planned to test whether automated music therapy could help manage agitation and sleep problems in people with severe Alzheimer's living in nursing homes. An actigraph would detect sleep issues and trigger music sessions automatically. The trial was withdrawn before any…

This study looks at whether special video games (serious games) that combine physical and mental exercises are a good value for managing Alzheimer's disease. About 136 people with mild to moderate Alzheimer's will either play these games with a therapist or receive usual care. Re…

This Phase 2 trial tests a single intravenous dose of ketamine in 20 hospitalized teens and young adults with anorexia nervosa or atypical anorexia. Researchers want to see if ketamine helps the brain become more flexible, making it easier to learn new, positive associations with…

This study tests a speech therapy method called Rapid Syllable Transition (ReST) in children aged 5 to 8 with childhood apraxia of speech, a condition that makes it hard to say sounds correctly. The goal is to see if the therapy is practical and helps improve speech clarity and m…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study looks at whether a guided relaxation practice called Yoga Nidra can lower stress, anxiety, and sleep problems in nursing students during their hospital training. About 110 fifth-year nursing students will take part. Researchers will measure changes using questionnaires…

This study tests whether a short, intensive course of cognitive behavioral therapy (CBT) over 2 weeks works better than the usual weekly sessions over 6 months for people with anxiety disorders. 120 adults with conditions like panic disorder, OCD, or PTSD will be randomly assigne…

This study tests a 12-session group program called Family Connections Transdiagnostic for relatives of people with emotional dysregulation disorders (like eating disorders or personality disorders). The program teaches skills in mindfulness, emotional regulation, and problem mana…

This study planned to see if using virtual reality (VR) before a brain stimulation treatment called TMS could help people with OCD feel more comfortable. It was designed for adults already approved for TMS. However, the study was withdrawn before any participants were enrolled, s…

This study aimed to see if a voice-changing device could make exposure therapy easier for people with PTSD. Patients would read their trauma story aloud while software altered their voice's emotional tone, hoping to reduce distress. The study was withdrawn before any participants…

This study tests whether a more targeted form of transcranial magnetic stimulation (TMS) can help people with schizophrenia whose symptoms don't improve with medication. The treatment uses each patient's own brain wave frequency (alpha rhythm) and MRI scans to precisely stimulate…

This study tests whether combining transcranial magnetic stimulation (TMS) with virtual reality exercises and physical therapy can improve symptoms like balance, fatigue, and thinking in people with multiple sclerosis. Thirty participants will receive both real and sham TMS in a …

This pilot study tests whether a daily 15-minute massage plus guided relaxation with music can prevent delirium in critically ill patients. About 120 adults in the ICU will be randomly assigned to receive the relaxation intervention or standard care for up to five days. The main …

This study looks at two ways of giving schema therapy to people with borderline personality disorder (BPD): one-on-one sessions or a mix of individual and group sessions. The goal is to see which format reduces BPD symptoms more and has fewer people dropping out early. About 132 …

This study tests whether a 20-week program of exercise alone or exercise combined with cognitive training can improve thinking and memory in breast cancer survivors. 108 women who have finished primary treatment will be assigned to one of three groups: dual-task training, exercis…

This study tests a 4-session group program called the Rational Positive Parenting Program (s-rPPP) for mothers of children aged 6-12 with disruptive behaviors like aggression and defiance. The program teaches parents to change unhelpful beliefs and manage emotions to improve chil…

This study aimed to see if trazodone works better than quetiapine or a placebo for treating confusion (delirium) in adult surgical ICU patients. It planned to measure how long delirium lasts, sleep quality, and side effects. However, the study was withdrawn before enrolling any p…

This study tests a coaching program called CuRB-IT for family caregivers of people with dementia. The program includes 9 video sessions over 12 weeks to help caregivers manage care-resistant behaviors (like refusing help) and improve their own coping skills. About 266 caregivers …

This study tests a program that combines family group sessions with a virtual peer mentoring program for US-born teens (ages 14-17) whose parents resettled as refugees. The goal is to reduce symptoms of PTSD, depression, anxiety, and behavior problems caused by intergenerational …

This study tests whether inhaling rosemary essential oil can improve memory, attention, and other thinking skills in healthy adults. 63 participants will either sniff rosemary oil or a placebo for 14 days and take brain tests before and after. The goal is to see if this natural r…

This study tests a 12-session group therapy program (G-BCBT) for active duty military personnel who have recent suicidal thoughts or a recent suicide attempt. The therapy teaches emotion regulation, cognitive flexibility, and relapse prevention skills. Researchers will measure ch…

This study tests whether watching 10-minute 360° nature videos twice a week for 12 weeks can improve quality of life, mood, and agitation in nursing home residents with dementia. Sixty residents will be randomly assigned to either the virtual nature program or their usual care. R…

This study aimed to see if a telehealth skills group could help middle and high school students with ADHD improve their organization, motivation, and grades. Both the treatment and control groups were delivered via Zoom. However, the study was withdrawn before enrolling any parti…

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—for people with severe depression that hasn't improved with standard medications. About 100 adults with major depression or bipolar depression will receive one …

This study tests whether inhaling lavender and lemongrass essential oils through a personal necklace can reduce pain and anxiety during active labor. 70 women in labor will be randomly assigned to receive either the aromatherapy or a placebo (sweet almond oil). Researchers will m…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study tests a new interview tool called the Opioid Timeline Follow-Back (OpiTLFB) to better track nonmedical opioid use, including fentanyl. Thirty adults who use opioids at least once a week will fill out a calendar and answer questions about their drug use over the past 30…

This study looks at whether insurance claims data can be used to reliably identify two serious complications in people with Alzheimer's disease: brain hemorrhages larger than 1 cm and new-onset seizures. Researchers will analyze records from 600 Alzheimer's patients, linking insu…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study looks at whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder and healthy volunteers make risky or uncertain decisions. Participants will have MRI scans and computer tasks, and some will receive real or sham TMS. The goal is to…

This study enrolls 130 Hispanic adults aged 55+ without dementia to see if a 12-week phone-based coaching program helps them become more active. Participants are randomly assigned to either the coaching program or a general brain health education group. The goal is to see if the …

This study looks at a special training program called Fundamentals of Communication in Surgery (FCS) for surgeons and surgery trainees. The goal is to see if the training helps surgeons communicate better with patients and each other. About 600 people will take part, and research…

Researchers at UC San Diego want to know whether doing a mental task changes breathing differently in people who take opioid pain medicine every day, people with obstructive sleep apnea, and healthy adults. The study compares three groups of 40 adults in total. Each participant v…

This study develops and tests a decision-making program designed specifically for African American adult daughters who make healthcare choices for their parents with dementia. The program focuses on communication, problem-solving, and understanding the healthcare system, all whil…

The SHAKTI study is a 5-year observational project that will follow 6,000 people of Asian or Pacific Islander descent, aged 10 and older, with depression or related mood disorders. Researchers will collect a wide range of data—including lifestyle, clinical history, blood and stoo…

Researchers at the University of Management and Technology Sialkot are studying how motor coordination relates to postural stability in children with autism spectrum disorder. The study includes 30 children aged 5 to 12 who can stand and walk without help. Parents answer a questi…

This study tests whether giving smokers and former smokers a personalized risk report (based on clinical and genetic factors) helps doctors order lung cancer screening and helps patients follow through. About 915 participants will be randomly assigned to usual care or one of two …

This study surveys over 21,000 nurses at Mayo Clinic to measure levels of moral distress, moral injury, and post-traumatic stress. Participants fill out questionnaires about their experiences and well-being. The goal is to understand how these issues vary by work setting, special…

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, autism, schizophrenia, and endocrine disorders, as well as healthy volunteers. Researchers aim to compare brain anatomy and function across different groups and ages. The goal is to …

This study aims to test a new assessment tool called the ANA, which uses surveys and computer tasks to measure three key brain functions related to addiction. Researchers will study 1,400 adults with alcohol use disorder to see how these brain functions relate to drinking behavio…

This study follows 25 people with spinocerebellar ataxia type 7 (SCA7) for up to 5 years to learn how the disease changes vision, coordination, and thinking. Participants will have yearly eye exams, brain scans, and neurological tests. No treatment is given; the goal is to gather…

This study tests whether a brief information session can help people with risky alcohol use feel more comfortable seeking help. Many avoid help due to shame or fear of consequences, even though effective treatments exist. Researchers will measure changes in participants' willingn…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study follows 2,500 people aged 10 and older with depression or bipolar depression over 10 years. Researchers collect data on symptoms, brain scans, genetics, and lifestyle to find patterns that predict how someone will respond to different treatments. No experimental drugs …

This study follows 817 military personnel who served in Iraq to see how war affects mental health, thinking skills, and daily life over time. Participants complete surveys and in-person tests on mood, stress, and memory. The goal is to learn how conditions like PTSD develop and c…

This study investigates how the brain processes anticipation of rewards in people with bulimia nervosa. Researchers will use brain scans (fMRI) and daily-life surveys to compare 100 participants—those with bulimia and healthy controls. The goal is to identify neural and psycholog…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

Researchers are testing a coaching program to help primary care clinics in rural West Virginia screen and treat opioid use disorder, HIV, and hepatitis C. The program includes group priority-setting, rapid-cycle improvement coaching, and provider training. Twenty clinics will tak…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if supporting the moth…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

This study follows 285 older adults with Alzheimer's or mild cognitive impairment to learn how they make decisions about aging in place or moving to long-term care. Researchers will track planning and preferences over time. No treatment or intervention is being tested.

This study trains police officers and first responders to better communicate with people who have aphasia, a condition that affects speech and understanding. 75 participants from the Madison Police Department will take part for up to 6 months. The goal is to see if training impro…

This study follows 110 people with brain metastases who are receiving either focused or whole-brain radiation. Researchers use advanced MRI scans and memory tests before treatment and for two years after to see if the scans can predict thinking and memory problems. The goal is to…

This study tests whether brain wave (EEG) measurements can predict who will get better from a non-invasive magnetic stimulation treatment for depression called rTMS. Researchers will treat 30 adults with depression using rTMS and compare their EEG patterns before and after treatm…

This study uses a noninvasive brain stimulation technique called TMS, combined with brain scans, to understand working memory problems in people with early psychosis. Twenty participants will receive both active and placebo TMS to see how it affects brain activity and memory perf…

Researchers are running a long-term observational study to see whether changes in clinical measurements over time can predict meaningful patient outcomes better than a single snapshot. The study will enroll about 1,000 adults and follow them, collecting routine clinical data, lab…

This observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …

Researchers at Sahlgrenska University Hospital are collecting cerebrospinal fluid through lumbar puncture from people with alcohol use disorder and from healthy volunteers across different ages. They will measure molecules such as dopamine and test how the fluid affects nerve cel…

This completed study tested different messages to see which ones make adults more willing to get the HPV vaccine, which prevents certain cancers. Over 5,300 adults aged 18-45 were randomly assigned to read one of five theory-based messages or a control message. The goal was to fi…

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if ca…

This study compares two different radioactive tracers used in PET scans to measure tau tangles in the brain, a hallmark of Alzheimer's disease. Researchers will scan over 800 participants with either Flortaucipir or MK-6240 to see how well they work over time. The goal is to harm…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

Researchers are testing whether combining genetic data, blood or brain biomarkers, and detailed thinking and memory tests can better predict who might develop Alzheimer's disease. The study follows 200 adults with either mild memory complaints or early cognitive decline over two …

Researchers at Mayo Clinic are reviewing records from 1,500 women who had an epidural for labor pain and then needed a cesarean delivery. They are comparing three epidural placement techniques: traditional epidural, dural puncture epidural (DPE), and combined spinal-epidural (CSE…

Researchers at Baylor College of Medicine are studying how brain activity and visible behaviors, like head movements, facial expressions, and voice tone, change during tasks that trigger OCD symptoms. Adults with OCD and healthy volunteers will complete tasks that provoke distres…

Researchers are investigating whether brain connectivity and blood markers differ between adolescents with ADHD and healthy teens. The study includes 40 teens with ADHD and 40 matched controls, aged 10 to 18. Participants undergo brain imaging, blood tests, and assessments of exe…

Researchers at the University of Pittsburgh are testing whether brief exposure to blue light, compared with red light, can stabilize emotional brain function in adolescents and young adults with depressive symptoms. Participants undergo brain scans while viewing light, complete a…

Researchers at the University of Cincinnati are studying how brief electrical brain stimulation affects the brain waves that help us stay focused and switch between tasks. They will record brain activity from over 100 electrodes in adults with epilepsy who are already undergoing …

This study tests whether methylphenidate (Ritalin) can help weaken memories that link drug cues to cocaine use. Fifty-one adults with cocaine use disorder will receive either methylphenidate or a placebo before recalling drug-related memories, while brain activity and skin respon…

This study looks at what happens when people who use cannabis regularly take it daily for two weeks. Researchers will measure pain sensitivity, feelings of a 'good drug effect,' and natural cannabis-like chemicals in the blood. The goal is to understand if daily use changes pain …

This trial tests a home-based intervention called Khanya-Ekhaya, delivered by community health workers, to support the mental health of people living with HIV in South Africa. The intervention combines counseling techniques like motivational interviewing and problem-solving thera…

This study tests whether wearable biosensors can accurately track symptoms like heart rate, breathing, sleep, and movement in people with Rett syndrome. Up to 30 participants will use the devices at home for 9 weeks and also undergo one overnight sleep study in the clinic. The go…

This study compares a new selegiline skin patch to an existing one (EMSAM®) to see how well the skin tolerates it. Researchers will apply both patches to 230 healthy adults and check for irritation or allergic reactions. The goal is to ensure the new patch is safe for the skin be…

This study investigates whether biological markers can predict how well people with depression or bipolar disorder respond to an online cognitive behavioural therapy program called the Wellbeing Course. Researchers will enroll 200 adults who previously participated in a CAN-BIND …

This study will use wearable devices like heart rate monitors and sleep trackers to see how financial stress and news affect your body. Researchers will follow 2,500 adults remotely, collecting data on heart rate, sleep, and stress levels. The goal is to create AI tools that can …

This study examines a program in two Boston-area jails designed to make HIV testing and treatment easier for people with opioid use disorder. Researchers will follow about 59 participants who are leaving jail within a month to see if they use HIV services, get tested, or take PrE…

This observational study follows up to 3,000 people who were previously screened for anti-amyloid Alzheimer's prevention trials but did not qualify based on amyloid levels. Over about 6 years, researchers will track changes in blood biomarkers, brain amyloid (via PET imaging), an…

This study tests a program called Preschool and Me (PreM) that helps families of children with developmental delays or disabilities connect with school-based services. The program uses a care plan and a navigator to guide families through the process. Researchers hope this will i…

This study looks at whether a digital version of the classic clock-drawing test can help identify older adults at higher risk for confusion or memory issues after surgery. Researchers will analyze data from thousands of patients aged 65 and older who take the test before an opera…

This study follows 1,000 adults aged 50 and older to see how the health of their heart and blood vessels relates to early signs of Alzheimer's disease and brain aging. Researchers will use brain scans, memory tests, and blood or spinal fluid samples to look for connections betwee…

This program collects brain and other tissue samples from adults, including healthy individuals and those with memory disorders, to support research on Alzheimer's disease. Participants are typically enrolled in affiliated studies or approved on a case-by-case basis. The goal is …

This study uses PET imaging to measure two key proteins in the brain—amyloid and tau—that are hallmarks of Alzheimer's disease. Researchers will follow 120 participants over five years, including people with normal aging, mild cognitive impairment, and dementia, to see how these …

This study follows about 2,200 mothers and their children in Cox's Bazar, Bangladesh, including Rohingya refugees and local families. Researchers want to understand how growing up in conflict and displacement affects child development and mental health. They are also looking at w…

This study investigates whether people with neurodegenerative diseases—like Alzheimer's, Parkinson's, or ALS—show changes in behavior, social circumstances, or health before and after their diagnosis. Researchers will compare the records of over 61,000 patients with those of matc…

This study is looking at why some people develop persistent pain after breast cancer surgery while others do not. Researchers will follow 220 adults undergoing breast cancer surgery, using questionnaires and a pain sensitivity test to identify risk factors. The goal is to find re…

This study uses stem cell technology to create brain cells from people with anorexia nervosa and compare them to cells from healthy individuals. The goal is to understand how specific brain cells, called hypothalamic neurons and microglia, function differently in anorexia. By pro…

This trial tests whether a six-session financial literacy and gender-equality program for married couples in rural India can change how women and men think about reproductive decision-making for younger generations. Researchers ask participants who should have the main say in whe…

This study follows children aged 6 to 21 who have a CNKSR2 gene mutation, which can cause epilepsy, language difficulties, and intellectual disability. Researchers will use brain scans, EEGs, and developmental tests to track how the condition changes over time. The goal is to cre…

This study uses advanced PET scans to investigate how brain inflammation and tau protein buildup affect synaptic density in people with Alzheimer's disease. Researchers will compare Alzheimer's patients to healthy controls over two years, tracking changes in these brain markers. …

This study explores whether wearable accelerometers and cameras can automatically detect delirium in intensive care unit patients by tracking changes in movement and facial expressions. Delirium, a sudden state of confusion, often goes undetected despite being common in hospitali…

This study follows women who have had surgery for a female genital fistula, a hole between the bladder and vagina that causes incontinence. The goal is to find factors that can be changed to prevent the repair from breaking down or new incontinence from developing. Researchers wi…

This study follows children and adolescents who experienced trauma to see how many still have PTSD or Complex PTSD two years later. Researchers will also look at factors like symptom severity, resilience, sleep, and anxiety that may influence recovery. The goal is to better under…

This study investigates cognitive problems in intensive care patients with acute respiratory distress syndrome (ARDS) who develop delirium (sudden confusion). Researchers use a non-invasive EEG cap and auditory tests to measure brain activity at the bedside. The goal is to identi…

This study aimed to see if Alzheimer's disease affects the nerves in the gut, similar to what happens in Parkinson's disease. Researchers planned to take extra colon biopsies during routine colonoscopies from people with Alzheimer's, Parkinson's, and healthy individuals to compar…

This study looks at whether two blood markers, zonulin and LBP, can help detect liver damage in people with both ulcerative colitis (UC) and fatty liver disease. Researchers will measure these markers and use a special ultrasound to check liver stiffness in 100 adults with UC who…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This observational study surveys 150 adults with severe mental illness to learn how they use AI chatbots for mental health support. Participants answer a one-time anonymous online survey about their experiences, expectations, and concerns. The goal is to understand usage patterns…

This study was designed to compare decision-making skills between bipolar patients who had attempted suicide and those who had not. Researchers planned to use computer tasks and questionnaires to measure thinking patterns. However, the study was withdrawn before enrolling any par…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study explores how anxiety contributes to treatment-resistant depression. Researchers will follow 37 adults with depression to see if anxiety levels can predict who will have a harder time recovering. The goal is to better identify at-risk patients and develop more targeted …

This study looks at whether a mindfulness program can improve attention and brain connectivity in 11-14 year olds who have a family history of mood disorders and high mood swings. About 224 teens will be randomly assigned to mindfulness or a health education class. The goal is to…

This study tests a new radioactive compound called F 18 T807 that lights up tau tangles in the brain during a PET scan. Researchers want to see if the amount of tau relates to memory and thinking problems in people with a rare, inherited form of Alzheimer's disease. About 130 adu…

This study uses a radioactive tracer called [18F]MK-6240 to take detailed pictures of tau protein clumps in the brain, a hallmark of Alzheimer's disease. Researchers will scan 200 people from families with a rare genetic form of Alzheimer's to see how tau buildup changes over tim…

This study looks at how the severity of depression relates to erectile dysfunction and premature ejaculation in 100 married men aged 25–60 in the Sohag region of Egypt. Participants are clinically diagnosed with depression and sexually active. Researchers will use standard questi…

This study follows 600 mentally ill offenders in Italy and California over three years to compare two very different treatment systems. Italy uses community-based care, while California relies on long-term hospital stays. Researchers will track violence, recovery, and functioning…

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study aimed to see if personalized computer-based brain exercises could improve thinking skills in adults with HIV who have mild memory or attention problems. Researchers planned to enroll 120 people aged 40 and older, giving half of them training focused on their weakest me…

This study follows 640 adults with normal cognition, mild cognitive impairment, or Alzheimer's disease to track brain changes over time. Researchers use advanced brain scans and genetic tests to understand how Alzheimer's develops. The goal is to find better ways to diagnose and …

This study aimed to see how well a blood test (phosphatidylethanol) detects heavy alcohol use. Researchers planned to compare test results in heavy drinkers and check how stable the samples are over time. However, the study was withdrawn before enrolling anyone, so no results are…

This study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understan…

This study looks at whether training pediatricians to assess how mothers and babies interact can help identify early signs of child behavior issues or postpartum depression. Over 3,500 mother-child pairs are involved, with babies seen at their one-month checkup. The goal is to se…

This study explores whether smartphone sensors can detect early changes in behavior that might signal cognitive decline. About 100 adults aged 65 and older living in assisted living facilities will have an app on their phones that tracks movement, typing patterns, and app usage f…

This study observes 35 people in residential treatment for substance use disorders to measure behavioral rigidity—the tendency to get stuck in inflexible thinking patterns. Participants complete weekly questionnaires and have their therapy sessions analyzed for language patterns.…

This study aimed to see if measuring sertraline (Zoloft) levels in the blood and checking a specific gene (CYP2C19) could help doctors give the right dose to people with major depression. The goal was to reduce side effects and improve treatment. However, the study was withdrawn …

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study enrolls 500 adults with a sleep condition called REM sleep behavior disorder (RBD), which often leads to Parkinson's disease or related brain disorders. Researchers will track symptoms like thinking, movement, and smell to develop a rating scale. The goal is to prepare…

This study aimed to see if electronic cigarettes could help people with depression smoke less or quit. It planned to follow smokers for 12 months, measuring how many cut down or stopped. However, the study was withdrawn before enrolling anyone, so no results were collected.

This study uses data from over 30,000 Swedish adults to see if using snus (including newer white nicotine pouches) is linked to heart disease, metabolic problems, and poor mental health, independent of smoking. Researchers will compare current, former, and never-users using advan…

This study is testing whether regular cognitive activities (like video games and book clubs) and physical exercises (like walking and Zumba) can slow down age-related decline in thinking and physical health. Researchers are following 400 healthy Malaysian adults aged 60 and older…

This study aimed to see if monthly video calls could help track swallowing issues in people who had intensive rehab after throat cancer treatment. It planned to enroll adults with chronic swallowing problems and check if they could attend at least 3 out of 5 remote sessions. Howe…

This study is testing whether a simple saliva test can help doctors choose the right psychiatric medications for children and teens aged 6 to 24. The test looks at the child's DNA to predict how they might respond to different drugs. Researchers hope this will lead to fewer side …

This study is testing a new way to analyze MRI brain scans, called Cortical Disarray Measurement (CDM), to see if it can help diagnose Alzheimer's disease more accurately. Researchers will follow 400 people with mild memory or thinking problems over time, comparing CDM results wi…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study follows 70 Romanian adults with alcohol use disorder who have been sober for at least a year. Researchers use personality tests and spiritual well-being surveys to see what predicts a calm, fulfilling sobriety versus a difficult one. The goal is to better understand re…

This study looks at whether a mobile peer support app can help people who have been in jail or prison and are recovering from opioid use disorder feel more connected and less lonely. About 90 adults who recently took medication for opioid use disorder while incarcerated will use …

This study looks at medical records of 50 cancer patients who say cannabis helped stop their tumor from growing or shrank it. Researchers want to see if there is real evidence behind these claims. The goal is to gather information, not to test a new treatment.

This study follows 250 patients who have recovered from an eating disorder. Nurses will call them once a year for three years to check on their health and see if they relapse. The goal is to learn what factors might increase the risk of relapse, such as age or exercise habits.

This study compares 6 months of group music activities versus circus activities in 200 infants (8-12 months old) with or without a family history of dyslexia. Researchers will measure language skills, brain responses to sounds, and social-emotional factors. The goal is to see if …

This study tests a therapy where parents of children with autism (ages 1.5 to 3) get video feedback to help them better understand and respond to their child's signals. The goal is to improve joint attention, a key skill for social communication. Twenty-seven families will be ran…

This study looks at whether anxiety and depression are connected to carpal tunnel syndrome in medical students. Researchers will measure the median nerve in the wrist and check students' anxiety and depression levels using questionnaires. The goal is to see if there is a link bet…

This study uses brain scans (fMRI) to compare how teenage girls with eating disorders and healthy teens react to pictures of food. Researchers want to find differences in brain activity and structure that might explain why some teens develop anorexia. The goal is to better unders…

This study is creating a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will collect data from clinics across Texas to better understand these conditions and develop models to predict outcomes. The goal is to improve popula…

This study is testing a new way to care for people with rare diseases. It will use advanced genetic testing and a team of specialists to help diagnose patients faster and coordinate their care better. The study involves 136 participants with certain rare diseases and aims to redu…

This study looks at how small amounts of alcohol and THC (the active part of cannabis) affect driving in a simulator. Forty adults aged 21 to 55 who have used both substances before will take part. The goal is to understand how these drugs change driving performance and thinking,…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking. About 40 occasional cannabis users who also drink alcohol will use a driving simulator after taking controlled doses. The goal is to understand the risks of driving under the inf…

This study looks at whether a method called the 15-Method can help doctors in general practice better identify and treat patients with alcohol problems. The method combines screening with treatment options already available in primary care. Researchers will track how many patient…

This observational study at Yale uses PET brain scans to measure CB1 receptor availability in 15 people who currently use synthetic cannabinoids. Researchers want to see if these receptors are lower in users and how that relates to thinking skills and brain rhythms during withdra…

This study looks at how alcohol and cannabis, alone or together, affect driving and thinking. About 40 occasional users aged 21–55 will take part. They will inhale low-dose THC (like a quarter of a joint) and drink alcohol, then test their driving on a simulator and complete ques…

This study at Yale University looks at how THC, the active ingredient in cannabis, affects short-term and long-term memory. Researchers will give 80 adults who have used cannabis before either a low dose of THC or a placebo and then test their memory. The goal is to better unders…

This study looks at how alcohol and cannabis, alone or together, affect driving ability and thinking. About 40 adults aged 21–55 who have used both substances before will take part. They will complete simulated driving tests and questionnaires after receiving the substances. The …

This study tests an adaptive deep brain stimulation (aDBS) system in just 3 people with severe, treatment-resistant OCD. The device is implanted in the brain and chest, and it aims to detect brain signals linked to OCD distress and adjust stimulation automatically. The main goal …

This study looks at how Transcranial Magnetic Stimulation (TMS) changes the brain in people with major depression. Researchers will use MRI scans to track these changes over 6 weeks. The goal is to better understand how TMS works, not to test a new treatment. 40 adults aged 18-65…

This study explores why Black, Indigenous, and People of Color (BIPOC) may have lower rates of starting and sticking with antidepressants after a one-time psychiatric consultation. Researchers will survey 60 adults diagnosed with depression to see if race affects whether they get…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study follows over 6,600 elderly patients (aged 60+) who had major surgery to see if lighter anesthesia helps them live longer. The original trial found no difference in survival at one year, but this follow-up checks for effects beyond that, including on cancer recurrence a…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…