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Laughing gas takes on the needle: could a simple breath ease one of Medicine's most uncomfortable procedures?

NCT ID NCT07618676

Symptom relief Sponsor: Institute for Oncology and Radiology of Serbia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 2 times

Summary

This study investigates whether breathing a 50:50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain and anxiety during insertion of a central venous catheter, a common but uncomfortable procedure. Adults aged 18 to 65 who have never used nitrous oxide will be randomly assigned to receive either the gas mixture or the standard local anesthetic injection. Researchers will measure pain levels, anxiety, and patient satisfaction to see if the gas offers a better experience.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
50:50 nitrous oxide/oxygen gas mixture
What this could lead to
If effective, this approach could offer a simple, non-invasive way to reduce pain and anxiety during central line placement, improving patient comfort.
What could go wrong
This is a small, single-center trial with 62 participants, so results may not apply broadly. Nitrous oxide can cause side effects like nausea or dizziness, and it may not work better than the standard local anesthetic.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 62 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects who have not previously received Nitrous Oxide. * Subjects of both sexes, aged between 18 and 65 inclusive. * Subjects who have signed informed consent with full disclosure; no study-related procedure may begin until the subject signs the consent form. Exclusion Criteria: * Infection at the planned puncture site. * Pregnancy. * Intracranial hypertension. * Vitamin B12 deficiency. * Hemodynamic instability. * BMI over 35. * Glasgow Coma Scale (GCS) score less than 15. * Presence of chronic pain. * Neurological disorders. * Hematologic disorders. * Systemic or intrathecal methotrexate therapy * More than two attempts at venous puncture (Subject Withdrawal Criterion). * Subject experienced an adverse event requiring early discontinuation (Subject Withdrawal Criterion). * Withdrawal of consent by the subject (Subject Withdrawal Criterion)

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Conditions

The condition(s) this trial relates to.

Acute Pain anxiety anxiety disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Anxiety Central venous catheter

Contacts and locations

Locations

  • Institute for Oncology and Radiology of Serbia

    Belgrade, Savski Venac, 11000, Serbia

More trials for these conditions

Other studies related to the condition(s) this trial covers.