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Brain zaps and VR games: a new hope for MS symptoms?

NCT ID NCT07593807

Symptom relief Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether combining transcranial magnetic stimulation (TMS) with virtual reality exercises and physical therapy can improve symptoms like balance, fatigue, and thinking in people with multiple sclerosis. Thirty participants will receive both real and sham TMS in a crossover design, with outcomes measured over a year. The goal is to see if this non-drug approach can ease multiple MS-related problems at once.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial magnetic stimulation (TMS)
What this could lead to
If it works, this could point toward a non-drug way to ease multiple symptoms of MS, like fatigue, balance problems, and brain fog.
What could go wrong
This is a small, early-stage trial with only 30 people, so results may not apply to everyone. The treatment is also complex and time-consuming, which might limit real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants with a confirmed diagnosis of Multiple Sclerosis. * Ability to understand and follow simple instructions and to participate in the experimental procedures. * Expanded Disability Status Scale (EDSS) score ≤ 6.5. * Ability to maintain upright standing position (with or without assistive device) and perform basic static and dynamic balance tasks required for the intervention. Exclusion Criteria: * Presence of metallic implants in the skull, cranial deformities, or absence of cranial vault. * Cardiac arrhythmias or atrioventricular block. * Congenital abnormalities, including congenital heart disease or pulmonary malformations. * History of seizures. * Use of medications that significantly interfere with autonomic nervous system function, such as antiarrhythmic drugs or insulin. * Inability to perform the proposed physical and virtual reality-based exercises. * Inability to tolerate neuromodulation or electrostimulation procedures. * Non-attendance at baseline or post-intervention assessment sessions, or absence in three or more intervention sessions. * Incomplete completion of study procedures or withdrawal for any reason.

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Conditions

The condition(s) this trial relates to.

communication disorder Depression multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis

Contacts and locations

Locations

  • ABEM - Associação Brasileira de Esclerose Múltipla

    São Paulo, São Paulo, Brazil

More trials for these conditions

Other studies related to the condition(s) this trial covers.