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Could a simple Pill-Size switch curb opioid dependence?

NCT ID NCT07750639

Disease control Sponsor: AdventHealth Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Sep 18, 2026 · Updated 3 times

Summary

This trial tests whether adjusting the number of non-opioid pain pills or adding gabapentin can reduce opioid use after hand, wrist, or elbow surgery. Participants are randomly assigned to one of three pain medication regimens and report their pain levels and any need for extra prescriptions. The goal is to find a way to manage pain effectively while lowering the risk of opioid dependency.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A combination of naproxen, acetaminophen, oxycodone, and gabapentin, given in different doses and pill counts after surgery.
What this could lead to
If successful, this could point to safer, more effective ways to manage post-surgical pain while reducing reliance on opioids.
What could go wrong
The trial is relatively small and results may not apply to all surgeries. There are also risks of side effects from the medications, including nausea, dizziness, and potential for opioid dependence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 260 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years old * Able to read, write and understand English * Undergoing hand, wrist, or elbow surgery Exclusion Criteria: * Inpatient surgery * Patients with a history of illicit substance use/abuse, patients that were prescribed codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, or oxymorphone. * Allergy or intolerance of NSAIDS, acetaminophen, gabapentin, or narcotics.

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Conditions

The condition(s) this trial relates to.

opiate dependence opioid abuse Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Opioid abuse (disorder) Opioid analgesia Opioid analgesic adverse reaction Opioid consumption

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AdventHealth

    Orlando, Florida, 32827, United States

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