Could interactive exercise at home be a weapon against Alzheimer's?
NCT ID NCT06340659
First seen Aug 06, 2026 · Last updated Sep 02, 2026 · Updated 3 times
Summary
This study tests whether combining aerobic exercise with cognitive training, delivered via interactive 'exergames' at home, can help prevent Alzheimer's in older adults who have memory concerns but no diagnosed dementia. Participants will be randomly assigned to either an exergaming program or a standard aerobic exercise program for three months. Researchers will measure changes in cognitive function, fitness, and blood biomarkers to see if the combined approach offers added benefits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Home-based exergaming (interactive exercise with cognitive training) compared to home-based aerobic exercise
- What this could lead to
- If effective, this approach could offer a practical, home-based strategy to slow cognitive decline and potentially reduce Alzheimer's risk in older adults.
- What could go wrong
- This is an early-stage trial with a modest number of participants, so results may not be conclusive. The interventions require consistent participation, and individual outcomes may vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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97 people
The number who actually took part.
- Started
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Aug 2024
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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65 to 99 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Cognitive complaint (defined as answering yes to the questions's "Do you perceive memory or cognitve difficulties?" and "In the last two years, has your cognition or memory declined?"; * Montreal Cognitive Assessement (MoCA) 26 or greater * Age 65 years and older; * English-speaking; * Without ACSM contraindication to exercise Exclusion Criteria: * Dementia or mild cognitive impairment diagnosis; * Neurological or major psychiatric disorder, alcohol/chemical dependency or recent medical condition (anethesia COVID-19 \["brain fog"\]) likely causing cognitive impairment; * Current enrollment in another intervention study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Minnesota
Minneapolis, Minnesota, 55414, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.