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Exercise plus brain games may fight 'Chemo Brain' in breast cancer survivors

NCT ID NCT06073717

Symptom relief Sponsor: University of Seville Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a 20-week program of exercise alone or exercise combined with cognitive training can improve thinking and memory in breast cancer survivors. 108 women who have finished primary treatment will be assigned to one of three groups: dual-task training, exercise only, or standard physical activity advice. Researchers will measure changes in executive function, physical fitness, and blood markers linked to muscle-brain communication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise program and dual motor-cognitive training
What this could lead to
If successful, this could point toward a non-drug way to ease 'chemo brain' and improve daily life for breast cancer survivors.
What could go wrong
This is a small, early-stage study (108 people) with no blinding, so results may not apply widely. The benefits may be modest or not last after the program ends.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 108 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with stage I-IIIA breast cancer * Completed primary treatment, including surgery, radiotherapy and/or chemotherapy * Scheduled to receive adjuvant endocrine therapy, or currently receiving adjuvant endocrine therapy * Without functional limitations or other illnesses that condition and prevent them from practising intense physical exercise * FACT-Cog questionnaire score ≥ 10th percentile considering age groups * Fluency in Spanish (spoken and written) Exclusion Criteria: * Undergoing radiotherapy and/or chemotherapy * FACT-Cog questionnaire score ≤ 10th percentile considering age groups * Congenital heart disease * Chronic lung disease * Severe psychiatric disorders * History of substance abuse, or dependence (other than tobacco) * Mood disorders require treatment (anxiety or depression) * Relapses (2-3 months before the study start)

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Conditions

The condition(s) this trial relates to.

breast cancer cognitive disorder Cognitive Dysfunction Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer survivors Cognitive impairment Executive dysfunction

Contacts and locations

Locations

  • Laboratorio de Ciencias del Deporte

    Seville, Sevilla, 41013, Spain

  • Oncoavanze

    Seville, Sevilla, 41013, Spain

  • SADUS - Servicio de Actividades Deportivas de la Universidad de Sevilla

    Seville, Sevilla, 41012, Spain

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