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Unlocking the mystery of persistent pain after breast surgery

NCT ID NCT03408717

Knowledge-focused Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This study is looking at why some people develop persistent pain after breast cancer surgery while others do not. Researchers will follow 220 adults undergoing breast cancer surgery, using questionnaires and a pain sensitivity test to identify risk factors. The goal is to find reliable predictors of long-term pain, which could help doctors personalize pain management and improve recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Questionnaires and mechanical temporal summation assessment
What this could lead to
If successful, this could lead to better ways to identify patients at high risk for persistent pain after breast surgery, enabling earlier interventions and improved pain management.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not apply to all patients or settings, and the risk factors identified may not be reliable enough for clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 220 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2018

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients undergoing breast cancer surgery

Ages

21 to 80 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged between 21 - 80 year old; * Healthy and/or have systemic medical conditions as reviewed by anaesthetist for surgery (ASA 1-3); * Undergoing breast cancer surgery. Exclusion Criteria: * History of intravenous drug or opioid abuse; * Current chronic daily treatment with corticosteroids (excluding inhaled steroids); * Previous history of chronic pain syndrome; * Obstetric patients.

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Conditions

The condition(s) this trial relates to.

Acute Pain anxiety disorder breast cancer breast neoplasm Chronic Pain chronic pain syndrome Depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Breast cancer Chronic pain Depression, anxiety

Contacts and locations

Locations

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • KK Women's and Children's Hospital

    Singapore, 229899, Singapore

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