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Jail-Based PTSD therapy could curb overdose deaths after release

NCT ID NCT07490717

Disease control Sponsor: University of Arkansas Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail and others after release. The goal is to see if treating trauma improves engagement with substance use treatment and reduces overdose risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cognitive Processing Therapy (CPT) and Written Exposure Therapy (WET)
What this could lead to
If successful, this could show that treating PTSD in jail helps people with addiction start and stay in substance use treatment after release, reducing overdose deaths.
What could go wrong
This is an early-stage trial testing a new care pathway, not a proven treatment. Results may not apply to other jails or populations, and therapy engagement may be low.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 338 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for all participants: * 18 years of age or older * Able to understand and speak English * Able to give informed consent Inclusion criteria for key stakeholders participating in Aim 1 (additional requirements): * All items listed in "Inclusion criteria for all participants" * Invited by the PI to participate, due to specific role within the project site Inclusion criteria for people incarcerated at the study site completing assessments in Aim 2 (additional requirements): * All items listed in "Inclusion criteria for all participants" * Incarcerated at the study site * Screened positive for probable PTSD and OUD/STUD as part of the SBIRT-J process * Have an expected duration of incarceration that is compatible with receiving trauma-focused treatment and completing assessments within the remaining timeline of the study Exclusion criteria for people incarcerated at the study site to enroll in the Hybrid trial in Aim 2 (additional requirements): * Unwilling to consent to randomization * Unable to provide locator information for post-release assessments * Currently experiencing psychiatric symptoms that would preclude participation in CPT or WET (e.g., severe behavioral dysregulation, severe psychotic symptoms)

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Conditions

The condition(s) this trial relates to.

injury opiate dependence post-traumatic stress disorder substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Co-occurring mental and substance use disorders Medications for opioid use disorder Opioid use disorder (OUD) Post traumatic stress disorder PTSD Post-traumatic stress symptoms Stimulant use & co-occuring opioid use disorders Stimulant use disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Pulaski County Regional Detention Facility

    Little Rock, Arkansas, 72204, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

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