Soaking away Alzheimer's? heat therapy trial targets blood sugar and brain health
NCT ID NCT06023407
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether regular warm-water baths can improve blood sugar control and brain energy use in healthy adults aged 65 and older who are at risk for Alzheimer's disease. Over 10 weeks, 60 participants will soak in warm water three times a week. Researchers will measure changes in blood sugar and brain activity to see if this simple approach could help protect the brain.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Water immersion heat therapy (soaking in warm water)
- What this could lead to
- If it works, this could point toward a simple, drug-free way to improve metabolism and potentially lower Alzheimer's risk in older adults.
- What could go wrong
- This is a small feasibility study, not a large trial. It's too early to know if heat therapy truly helps prevent Alzheimer's, and results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2024
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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65 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 65 and older * Stable medication doses (\>1 month) * Post-menopausal * Clinical Dementia Rating (CDR) of 0 * History of or current metabolic impairment (i.e. metabolic syndrome, pre-diabetes, Type 2 Diabetes, etc) Exclusion Criteria: * Excluded from or unable to complete an MRI scan. MRI compatible pacemakers will require cardiologist clearance prior to enrolling. * ACSM Risk score stratification of "High" unless cleared by a physician prior to participation. * Myocardial infarction or symptoms of coronary artery disease in the last 2 years. * History of or current diagnosis of disorders with the potential to impair cognition (i.e. AD, Parkinson's disease, stroke (defined as clinical episode w/ neuroimaging evidence in appropriate area to explain symptoms)). * Insulin-dependent (Type 1) Diabetes Mellitus. * Clinically significant chronic disease such as cancer, HIV, or acquired immunodeficiency syndrome. * Clinically significant depressive symptoms that may impair cognition, use of psychoactive and investigational medications, and significant visual or auditory impairment. * Orthopedic complications that would preclude individuals from safely entering a hot tub. * Untreated hypothyroidism or diseases associated with heat intolerance (i.e. Graves disease, etc). * Contraindication for temperature pill ingestion (i.e. inflammatory bowel disease, diverticulitis or related).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Univeristy of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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