METABOLIC DISEASE

This study tests whether an online training and peer support platform, called Support-t, can help teenagers with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either receive usual care or also get access to the platform. …

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells (the cells that make insulin) placed inside tiny capsules. The goal is to see if transplanting these cells is safe and can help adults with unstable type 1 diabetes who still have dangerous lo…

This study tests a new, less invasive procedure called PSAM that cuts some stomach muscles to slow down how fast food leaves the stomach, which may help people feel full longer and lose weight. It is for adults aged 18-70 with a BMI over 35 who are eligible for weight loss proced…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study tests whether an online training and support platform can help adults with type 1 diabetes better manage their blood sugar and well-being. About 322 participants will use the platform for 12 months, either through their usual clinic or on their own. Researchers will tr…

This study looks at whether adding stair climbing to daily routines can lower blood pressure more than brisk walking alone. About 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk wa…

This study tests whether taking a daily oil rich in linoleic acid (an omega-6 fat) for 8 weeks can improve insulin resistance in adults aged 20-60 who already have this condition. Participants will be randomly assigned to receive either the linoleic acid oil or a control oil, whi…

This study is testing a new treatment called CTX310, which uses CRISPR gene editing to turn off a gene linked to high cholesterol and fats. It is for adults aged 18 to 75 whose lipid levels remain high despite standard treatments. The goal is to see if the therapy is safe and can…

This study looks at whether a medication called SGLT2 inhibitor, already used for diabetes and kidney disease, can improve blood flow to the heart in women with HIV who also have diabetes or kidney problems. About 80 women will be randomly assigned to health education alone or he…

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study looks at whether treating ongoing sleep problems after PTSD therapy can also improve heart health in older adults. About 167 veterans aged 50 and older with PTSD and insomnia will receive talk therapy for PTSD, followed by a non-drug sleep program if needed. Researcher…

This study aims to learn more about hormone and metabolism disorders in children by examining their genes. Up to 15,000 children aged 3 months to 18 years with known or suspected endocrine or metabolic conditions, along with their family members, will participate. Researchers wil…

This study aims to better predict the risk of death in people with metabolic diseases like diabetes, obesity, or metabolic syndrome who are already in hospital care. Researchers will analyze blood samples and health data from 10,000 participants to build a personalized risk profi…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect blood, tissue, and perform imaging tests like MRI and CT scans. The goal is to improve diagnosis and understanding of these conditions. P…

This study follows 106 men who have had surgery for prostate cancer to learn how long it takes to regain bladder control, sexual function, and overall health. Participants receive standard care resources and are monitored for up to 12 weeks. The goal is to better understand recov…

This study follows people with propionic acidemia (PA), a rare metabolic disorder, to learn how the disease affects the body over years. Participants aged 2 and older visit the clinic annually for tests like blood draws, heart checks, and brain scans. The goal is to better unders…

This study aims to find common facial features in males with creatine transporter deficiency (CTD), a genetic condition that causes intellectual disability, seizures, and behavioral issues. Researchers will review photos and medical data from up to 19 participants aged 2 to 40. T…

This study looks at how having excess body fat in midlife (ages 40-60) might increase the risk of Alzheimer's disease. Researchers will compare brain scans and blood tests from 240 cognitively healthy adults to see if those with obesity show more brain inflammation or Alzheimer's…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to look for biological markers that could help understand these conditions better. The goal is to support…

This study is collecting blood and urine samples from 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze genes, proteins, and immune cells to find patterns that predict disease progression, complications, or response to t…

This study looks at why night shift workers have higher risks for heart disease and diabetes. Researchers will test if eating only during a set window each day (time-restricted eating) can improve blood pressure, blood sugar control, and blood vessel health. The study involves 50…

This study aims to learn more about rare disorders that affect how the body processes certain chemicals called purines and pyrimidines. These conditions can cause problems in the brain, blood, kidneys, and immune system, ranging from no symptoms to severe illness. Researchers wil…

This early-stage study is testing a new drug, SNS851, in 52 healthy adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo by injection. The main goal is to check for side effects, not to treat any disease.

This study aims to understand how environmental factors like pollution, diet, and stress contribute to human diseases. Researchers will collect blood, urine, hair, and other samples from 2,000 healthy adults aged 18 and older. Participants may also complete surveys and provide sa…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information so that future researchers can use them to discover what…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…