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Can a brain ZAP boost thinking skills in severe mental illness?

NCT ID NCT06378463

Symptom relief Sponsor: University of Groningen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether combining cognitive remediation training (a computer-based program to improve thinking skills) with mild brain stimulation (transcranial direct current stimulation) can help people with severe mental illness who live in supported housing. The goal is to improve daily functioning and personal recovery. 126 adults aged 18-65 are taking part, and the study compares the active treatment to a sham (fake) stimulation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS)
What this could lead to
If successful, this could point toward a way to improve thinking and daily living skills for people with severe mental illness who need supported housing.
What could go wrong
This is an early-stage study with only 126 participants, so results may not apply widely. The brain stimulation is mild, but individual responses can vary and benefits may be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 126 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * A psychiatric disorder that requires care/treatment (no remission of positive, negative and cognitive symptoms); * Severe disabilities in social and/or societal functioning (no functional remission); * Disabilities are the result of a psychiatric disorder; * Disabilities are structural (at least several years); * Coordinated professional care is necessary to realize a treatment plan; * Adults between the age of 18 and 65; * Sufficient written and oral mastery of the Dutch language. Exclusion Criteria: * Having previously received CIRCuiTS; * Metal implants inside the skull or eye; * Severe scalp skin lesions; * A history of previous seizures; * Alcohol or drug abuse.

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Conditions

The condition(s) this trial relates to.

psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Severe mental illness

Contacts and locations

Locations

  • Cosis

    Assen, Drenthe, 9400 AE, Netherlands

  • GGZ Friesland

    Leeuwarden, Provincie Friesland, 8932 PA, Netherlands

  • Lentis

    Zuidlaren, Drenthe, 9470 AC, Netherlands

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