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Can VR and a tiny ear ZAP ease shoulder pain and anxiety?

NCT ID NCT07198737

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 3 times

Summary

This study combines virtual reality with a gentle electrical pulse on the ear (called taVNS) to help people with chronic shoulder pain who are waiting for surgery. The goal is to see if this drug-free approach can reduce pain, anxiety, and depression. Only 10 people will take part, and the main focus is on whether the study is feasible and safe.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcutaneous auricular vagus nerve stimulation (taVNS) paired with virtual reality
What this could lead to
If it works, this could offer a drug-free way to manage pain, anxiety, and depression before shoulder surgery.
What could go wrong
This is a very small early feasibility study with only 10 people, so results may not apply widely. The combination is new and may not provide meaningful relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Jan 2026

Finished

Aug 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged over 18. * Ability to understand English * Ability to provide informed consent and attend in-person sessions * Chronic shoulder pain (pain lasting for at least 6 months) waiting on surgical pathway. * Comorbid mild-to-moderate anxiety or depression * Referred by a consultant orthopaedic surgeon. * Unresponsive to conventional treatment for 6 months including antidepressants, physiotherapy, and/ or oral analgesics * Mean NRS pain score ≥ 5 on most or all days either continuously or in motion Exclusion Criteria:● Inability to understand English and consent process * History of significant neurological or psychiatric conditions unrelated to chronic pain (e.g., epilepsy, psychosis, schizophrenia). * Skin lesions or piercing or extensive tattooing of the concha or Skin disease: infection, eczema or cancer of the ears or skin in region where VR headset or taVNS would sit * Presence of active implants (e.g. cochlear implant, implanted vagus nerve stimulator, cardiac pacemaker, implantable cardioverter defibrillator (ICD) deep brain stimulations or spinal cord stimulators, ventriculoperitoneal (VP) shunt). * Inability to tolerate VR (e.g., severe motion sickness, vertigo or balance issues, claustrophobia). * Fear of heights * Active infections, significant trauma, or other acute conditions affecting the shoulder. * Pregnancy and women trying actively to conceive * Pre-existing Persistent post-surgical pain-(\>6 months) from surgeries other than shoulder replacements * On- going alcohol and/ or drug problem * Widespread chronic pain conditions (fibromyalgia, complex regional pain syndrome) * Involvement in any clinical studies within the last 28 days prior to assessment * Other therapies such as other psychological interventions for A/D and pain in the shoulder are not allowed for the period of the study and follow up unless there is a psychiatric emergency. Participants may also not be involved in any trial on pain management or related to shoulders while participating in this VR/VNS trial.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • East kent Clinical trials Unit

    Margate, Kent, CT9, United Kingdom

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