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Can cannabis replace opioids for pain? new study investigates tolerance and withdrawal

NCT ID NCT04596644

First seen Nov 01, 2025 · Last updated Jun 08, 2026 · Updated 24 times

Summary

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if cannabis can be a safe, non-opioid option for chronic pain management.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • New York State Psychiatric Institute

    New York, New York, 10032, United States

Conditions

The condition(s) this trial relates to.

cannabis dependence Hyperalgesia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.