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Can a Personality-Targeted program keep teens off drugs?

NCT ID NCT04198974

Prevention Sponsor: St. Justine's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tests a school-based program called PreVenture, which uses brief workshops tailored to teens' personality traits to prevent substance use disorders. Over 12,500 students across Canada are taking part. The goal is to see if this approach can delay or reduce drug and alcohol use compared to standard school prevention.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PreVenture program (behavioral intervention: personality-targeted cognitive-behavioral workshops)
What this could lead to
If successful, this program could provide an effective, scalable way to prevent substance use disorders and prescription drug misuse in high-risk teenagers.
What could go wrong
This is a large trial, but results are not yet available. The program may not work as well in all schools or communities, and long-term effects are still unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 12,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2019

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 16 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Survey: All year 10 students with youth consent and parental passive or active consent (depending on local site requirements) will be eligible to participate in the survey * PreVenture: Eligibility will include consenting to study protocol and scoring 0.9 or more Standard Deviations (SD) above the school's norm on the 23-item Substance Use Risk Profile Scale (SURPS). The SURPS is a 23-item validated tool that assesses four personality dimensions along the internalizing (hopelessness (HOP) and anxiety sensitivity (AS)) and externalizing (impulsivity (IMP) and sensation seeking (SS)) spectrum. It has been shown to predict specific substance use patterns, including cannabis use and non-medical use of prescription drugs. Of those screened in a given year, approximately 1350 (45%) will report elevated personality profiles and will be eligible for intervention. Exclusion Criteria: \- Students that do not have either the site-specific parental consent/assent or youth consent will not be eligible to participate in the survey or PreVenture

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Conditions

The condition(s) this trial relates to.

Adolescent Behavior Psychological Well-Being substance-related disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adolescent behavior Adolescent development Substance use disorders

Contacts and locations

Locations

  • CHU Sainte-Justine Research Center

    Montreal, Quebec, H3T 1C5, Canada

  • Center for Mental Health and Addicitions

    Toronto, Ontario, Canada

  • Dalhousie University

    Halifax, Nova Scotia, Canada

  • University of British Columbia Okanagan Campus

    Kelowna, British Columbia, Canada

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