SUBSTANCE USE DISORDERS

This study is testing a brief, computerized treatment program designed to help teenagers aged 13-17 who want to cut down on their cannabis and alcohol use. Researchers will enroll 52 teens and their caregivers to see if the program helps reduce substance use over time. The main g…

This study is testing whether low-intensity focused ultrasound can help people with opioid or other substance addictions. Researchers are checking if this brain stimulation technique is safe and tolerable for 29 participants who are already in treatment programs. The ultrasound t…

This study tests a community program to help young people with opioid addiction. It combines outreach workers, medication treatment, counseling, and peer support to help participants stay in treatment longer. The goal is to reduce overdoses and help youth maintain recovery from o…

This study is testing whether a digital, self-guided therapy program using an avatar can help people manage substance use and reduce conflict in relationships. It will compare this online program to standard one-on-one talk therapy. The research involves 40 men who are entering o…

This study aims to find out if switching completely to e-cigarettes (vapes) is a better way to help people quit smoking while they are in treatment for substance use disorders, compared to using standard nicotine patches and lozenges. It involves 240 adults in South Carolina who …

This study is testing a virtual counseling program called MATTER. It aims to help people living with both HIV and a drug addiction by addressing feelings of shame and stigma that can make it hard to stay in medical care. The program teaches coping skills and provides resource sup…

This small pilot study is testing whether a self-guided version of eye movement therapy (A-EMDR) can help people who have both post-traumatic stress disorder (PTSD) and substance use problems. The research team wants to see if this therapy reduces PTSD symptoms and substance use …

This study is testing whether having a peer support worker—someone who has personally recovered from addiction—in the emergency room helps people with substance use disorders get connected to treatment and social services. Researchers will follow 400 people for 6 months to see if…

This study is testing a digital tool called MyPath that helps women with substance use disorders make informed decisions about contraception after giving birth. The tool guides women through thinking about their pregnancy goals, learning about fertility, and choosing contraceptiv…

This study is testing whether a new, non-invasive brain stimulation technique can help people who vape nicotine reduce their cravings and usage. The method, called temporal interference, uses mild electrical currents on the scalp to target deep brain areas linked to addiction. Re…

This study is testing whether a shorter, 12-week therapy program is practical and acceptable for people dealing with both addiction and trauma (PTSD). The program, called ECCCLORE, teaches skills to manage emotions, tolerate distress, and improve relationships. Researchers will e…

This study is testing whether a virtual reality (VR) program can help people in early recovery from stimulant use disorders. The VR experience is designed to help participants feel more connected to their future self, think more about the future, and value long-term rewards over …

This study is testing if ketamine, given through an IV, can help people with moderate to severe methamphetamine addiction reduce or stop their drug use. It will compare ketamine to another sedative drug (midazolam) in 120 adults over 12 weeks. Participants will receive eight IV i…

This study is testing a new family-based add-on therapy for teens who are already in treatment for substance use and also struggle with anxiety or depression. The program, called Fam-AID, teaches families skills to support their teen's mental health and aims to make standard trea…

This study is testing whether a computer-based brain training program can help people in forensic mental health care. The training aims to improve thinking skills like planning and problem-solving, which are often impaired. Researchers hope better thinking skills will lead to few…

This study is testing whether a new blood test can help doctors better diagnose depression and schizophrenia. Researchers will follow 500 participants with these conditions to see if the blood test can distinguish between different diagnoses and predict who will respond to treatm…

This study aims to see if training people who inject drugs to educate their own social circles is an effective way to increase HIV testing and connect people to prevention services. The research will involve 360 participants from syringe service programs in Maryland. Some partici…

This study is testing if starting a quit attempt during a specific phase of a woman's menstrual cycle makes it easier to stop smoking. It will enroll 1200 women who smoke daily and want to quit. Participants will be randomly assigned to start their quit attempt in one of two cycl…

This study compares two ways to help people with substance use disorders who have been involved with the justice system. Researchers want to see which approach works better at getting people to start HIV prevention medication (PrEP) or treatment (ART) and substance use treatment.…

This study is developing and testing a virtual reality tool designed to help prevent HIV infection and reduce substance abuse among young people who have experienced trauma. It involves young men who have sex with men and adolescents with substance use issues, aged 15-30, from th…

This study is testing whether a new feedback system helps social services work better for people. The system asks clients regularly how their support is going and what they think about it. Researchers will compare usual care to care using this feedback method for 400 people deali…

This study is testing whether a virtual reality (VR) training program can help people in long-term addiction treatment improve their ability to handle daily tasks and social situations. About 102 adults in Norwegian treatment centers will either use the VR program twice a week fo…

This study is testing whether a brief sleep improvement program can help people with substance use disorders stay longer in their recovery treatment. Researchers will work with 150 adults living in a residential recovery program who also have insomnia. The goal is to see if impro…

This study is testing a new sensory tool called the HealPod to help teens in juvenile detention manage difficult emotions like anger and anxiety. The pod uses sound, gentle vibrations, and light during a 5-minute session, followed by journaling and therapy. Researchers want to se…

This study is testing whether a brief writing therapy can help veterans who are dealing with both post-traumatic stress disorder (PTSD) and substance use problems. Veterans in standard addiction treatment will be randomly assigned to either write about a traumatic experience or a…

This study is testing whether offering yoga or physical therapy classes directly at opioid treatment centers can help people who are dealing with both chronic back pain and opioid use disorder. Researchers will compare these two programs to usual care to see which one better redu…

This study is testing a new training and support strategy for supervisors who oversee counselors in residential addiction treatment programs. The goal is to see if better supervision can reduce counselor burnout and turnover, and ultimately improve the quality of care for people …

This study is testing whether a gentle electrical brain stimulation technique can improve thinking skills like memory, attention, and decision-making in people with various mental health conditions and brain injuries. Researchers will recruit 600 adults with conditions including …

This study aims to see if brain scans can predict how well teens respond to a cannabis treatment program. Researchers will scan the brains of 80 teens (ages 14-17) who use cannabis, then have them join 10 weeks of virtual sessions where they report use and take drug tests. Teens …

This small pilot study is testing whether a telemedicine support program is practical and helpful for people in Alabama who are living with HIV and also dealing with opioid or stimulant addiction. The goal is to see if remote healthcare visits can help connect this group to neede…