SUBSTANCE USE DISORDERS

This pilot study will test whether a program called Yuva Sath, led by trained peer counselors, can help young people (ages 18-29) who inject drugs in India stay engaged in addiction treatment and use HIV prevention services. Sixty participants will receive one-on-one sessions and…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy is safe and can reduce depression and substance use in veterans and first responders who haven't responded to standard treatments. Fifty participants will re…

This study looks at whether using a phone app called the Safe and Sound Protocol (SSP) can help adults who are dealing with both substance use problems and past trauma. About 100 people in a residential treatment program will either use the real SSP app or a fake version for a we…

This study tests whether daridorexant, a recently approved insomnia medication, can improve sleep and daytime alertness in smokers who are trying to quit. Poor sleep is a major reason people relapse when quitting smoking. The study will involve 44 adult smokers who will take the …

This study tests whether a mobile app that teaches people about the brain can help those with opioid or stimulant use disorders stay in treatment. Forty adults currently on medication for substance use will use the app and report if they find it helpful and easy to use. The goal …

This study looks at what happens to the brain and body when adults aged 18-70 briefly stop taking tirzepatide, a medication for blood sugar and appetite. Researchers will measure changes in hunger, mood, sleep, and brain activity using scans and surveys. The goal is to understand…

This study tests a 12-week one-on-one support program for people who care for a loved one recently treated for substance use. Researchers want to see if the program is easy to complete and if participants find it helpful. About 18 adults will join weekly telehealth sessions and c…

This study will test if a technology-based tool is helpful and easy to use for people living in supportive housing who also have substance use issues. The tool includes videos and rewards to teach skills like cognitive behavioral therapy and life skills. Researchers want to see i…

This study aims to understand how kratom affects people who have used opioids in the past. Researchers will compare kratom with another substance and a placebo to see how it moves through the body and what effects it has. The goal is to learn more about the potential risks and be…

This study looks at whether federal rule changes made during the COVID-19 pandemic helped more veterans get and stay on medications for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data f…