SUBSTANCE USE DISORDERS

This study tested a program to help HIV-positive men who have sex with men (MSM) and struggle with substance use feel less shame and stigma about their health. The goal was to help them stay engaged in HIV care. Fifty participants tried the program, and researchers checked if it …

This study tested a special support program for veterans who have both bipolar disorder and substance use problems after they leave the hospital. Half of the 138 veterans received the new program, while the other half got extra safety check-ins. The goal was to see if the program…

This study looked at whether EMDR therapy, a treatment often used for trauma, can help people with substance use disorders who have also experienced traumatic events. 64 adults who were not actively using drugs took part. The goal was to see if EMDR could reduce relapse and under…

This study tested a new approach to help people with substance use disorders take their daily HIV prevention pill (PrEP) consistently. Participants used a digital pill that sends a signal to a smartphone app when swallowed, allowing researchers to track adherence in real time. Th…

This early-phase trial tested a virtual reality (VR) intervention designed to help people in early recovery from opioid use disorder think more about their future and reduce drug use. 104 participants who had been abstinent for at least 14 days but less than a year were split int…

This study tested a special program to help people with both bipolar disorder and substance use problems stick with their treatment after leaving the hospital. 178 adults took part, with half getting the new program and half getting extra safety check-ins. The goal was to see if …

This study tested a program called iSTRIVE to help people with HIV who also use opioids or stimulants stay engaged in their HIV care. The program taught emotion regulation and communication skills, and included video check-ins for taking medication. The goal was to see if the pro…

This study tested whether offering HIV prevention medicine (PrEP) right away at a syringe services program helps people stay HIV-negative. 90 adults who were already enrolled in the program and tested negative for HIV took part. Researchers measured drug levels in the blood to ch…

This study tested whether a smartphone app (GeoPassport) plus incentives and peer mentors could help men who have sex with men and transgender women leaving jail get HIV prevention services like PrEP and testing. 233 participants were split into two groups: one got routine case m…

This study tested a short therapy program for adults in residential rehab for substance use. The therapy combined techniques to improve emotion regulation, distress tolerance, and psychological flexibility. 36 participants were split into two groups: one received the therapy plus…

This study looked at whether adding a short writing therapy (Written Exposure Therapy) to a 28-day residential substance use program helps veterans who have both PTSD and substance use disorders. Fifty-six veterans took part. The goal was to see if the writing therapy was practic…

This study tested a phone-based counseling program for veterans with chronic pain who were at risk for substance misuse. Over 1,100 veterans took part, receiving brief advice and referrals to pain management services. The goal was to reduce pain and risky substance use through su…

This study tested a cognitive-behavioral therapy (CBT) delivered via telehealth to help Veterans with substance use disorders who feel lonely. 36 Veterans took part to see if the therapy was acceptable and could reduce loneliness and substance use. The goal was to gather informat…

This study tested a life-skills training program for 45 men aged 20 to 50 recovering from substance use disorders. The program aimed to improve their self-efficacy, or confidence in handling daily challenges. Participants completed a questionnaire before and after the training to…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people reduce their substance use. 198 adults with substance use disorder were split into three groups: standard care with group peer support, the online program alone,…

This study tested a smartphone-based breathing exercise (heart rate variability biofeedback) to help people with substance use disorder. 120 adults in early recovery used the app to practice slow breathing for 15 minutes daily. Researchers measured whether the app helped reduce c…

This study looked at whether slowly reducing (tapering) prescribed opioids helps people with long-term non-cancer pain. 140 participants were split into two groups: one started tapering right away, the other waited 4 months. The goal was to see if tapering could lower opioid use …

This study looked at whether a short sleep therapy program (BBTI) helps people with substance use disorders who live in a residential treatment center. About 83 participants wore sleep trackers, completed surveys, and did sleep diaries. The goal was to see if better sleep helps t…

This study worked with 51 healthcare professionals at primary care clinics to find ways to reduce stigma toward people who use drugs. The goal was to improve HIV prevention and care by combining staff education and policy changes. Researchers measured changes in attitudes and int…

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This study tested whether peer recovery coaches—people with lived experience—can help emergency department patients with substance use disorders connect to treatment and support. 144 adults were split into three groups: in-person coaching, video call coaching, or just a list of r…

This study tested a tablet-based screening tool for substance use, depression, and anxiety in over 10,000 HIV-positive adults during routine clinic visits. The goal was to see if computerized screening could help more patients get the mental health and substance use treatment the…

This pilot study tested a telehealth program called CRAFT-EP for families of people with early psychosis who also use alcohol or cannabis. 65 family members took part to see if the program could improve their wellbeing, including reducing depression and anxiety. The goal was to l…

This study tested a program to help 219 incarcerated individuals with HIV, hepatitis C, or substance use disorder transition from prison to community healthcare. Participants worked with a nurse case manager before and after release to plan and coordinate their care. The goal was…

This study looked at 129 teens aged 12-18 with substance use disorders to understand what parts of treatment actually help them get better. The goal was to find the key factors that lead to lasting improvement, so future treatments can focus on what works best. Teens and their pa…

This study tested a 6-session telehealth parenting program called THRIVE for mothers with substance use disorder. The goal was to see if offering it in a pediatric clinic is practical and well-received. Nine mothers took part, and researchers measured how acceptable and feasible …

This study tested whether coaching and electronic tools could help addiction treatment clinics improve care for people with opioid use disorder. Nearly 8,000 patients from clinics in New York took part. The goal was to increase use of addiction medications, keep patients in treat…

This completed study involved 65 African American adults who use cocaine or other illicit substances and want to cut down or stop. Researchers collected their feedback to develop a manual called I-DREM, designed to improve recruitment and retention of Black individuals in future …

This study checked if a questionnaire called the Behavioral Activation for Depression Scale (BADS) works well for people with substance use disorders. Researchers looked at data from 289 adults to see if the scale is reliable and accurate. The goal was to improve how depression i…

This study looked at how genes influence addiction and thinking skills like memory and decision-making. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, and people with substance use or other psychiatric disorders) complete questionnaires and c…

This study looked at whether an 8-week mindfulness and meditation program could help people with substance use disorders avoid relapse. Only 3 people took part, and while they all felt less stressed and more mindful after the program, two of them still relapsed within a year. One…

This early-stage study tested a single intravenous dose of CS-1103 in 32 healthy adults to see if it is safe and how the body processes it. The goal is to eventually treat methamphetamine abuse and overdose. No treatment was given for the condition itself; this trial only gathere…

This study looked at 106 people being treated for substance use disorders at Assiut University Hospital. Researchers collected information on their personal background, drug use patterns, and personality traits. The goal was to better understand who is affected and how to improve…

This study looked at 75 emergency room patients who had a non-fatal opioid overdose. Researchers measured the amount of xylazine, a veterinary sedative, in their blood and tested urine drug strips to see how well they detect xylazine. The goal was to better understand and identif…

This study tested whether adding a new clinic policy to a training program helps reduce stigma from mental health providers toward people with substance use disorders. Twelve providers from two clinics took part. The goal was to see if policy plus training works better than train…