SUBSTANCE USE DISORDERS

This study tests a community-based program called the Bridge Model to help people struggling with nicotine and substance use disorders. The program focuses on social needs like housing, jobs, and connections, not just quitting. Researchers will enroll 250 people in Ottawa and Tor…

This study tests whether a personalized program—including patient outreach, health education, and financial help—can lower the risk of dying from preventable causes like heart disease, heavy drinking, and HIV. About 87 low-income adults aged 35 to 64 are taking part. The program …

This study aims to eliminate hepatitis C among people who use drugs by combining mass screening with immediate treatment in community settings. About 3,400 participants in Paris, Marseille, Lyon, and Fort-de-France will be tested and treated, and will also invite their peers to j…

This study tests whether telehealth programs can help people manage their alcohol use and improve well-being. About 300 participants will receive either a remote group therapy program or standard care, with follow-up for up to 12 months. The goal is to see if virtual sessions hel…

This study tests whether a special team that treats both severe infections and substance use disorders together can help hospitalized patients who inject drugs. The goal is to lower death rates and prevent repeat hospital visits. About 480 adults will either get this integrated c…

This study looks at whether having a trained peer case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either usual care or extra support from a peer. T…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION versus working with a Peer Specialist. Researchers will track which approach leads to better treatment engagement, less substance use, and imp…

This study tests a clinic-supported mobile health program called Connections for up to 806 HIV patients who also have substance use disorders. Participants get support from their care team and peer mentors for one year to help them stay virally suppressed and attend appointments.…

This study looks at whether a therapy called RRFT, which treats both substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with trauma history and both conditions will be randomly assigned to RRFT or usual care. Rese…

This study tests a therapy program for mothers recovering from substance use disorders and their children (newborn to age 5). The program combines two proven therapies to strengthen the parent-child bond and improve family well-being. About 320 mother-child pairs will take part, …

This study tests a type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks and then put on a performance. Researchers…

This study looks at different methods to help primary care clinics screen adults for substance use problems. It involves 144 clinic staff from 48 practices. Researchers compare coaching, team learning, and financial rewards to see which works best.

This study aimed to see if combining patient surveys, staff training, and telemedicine could improve mental health and substance use care for people living with HIV. The program was planned for adults receiving HIV care at five clinics in Alabama. However, the study was withdrawn…

This study tests a program called ePORTAL HIV-S to make it easier for people with HIV to get screened for substance use disorders. The program uses online patient portals and clinic-based screening, even when patients don't have a scheduled appointment. Researchers will track how…

This study looks at two different approaches to help community hospitals start treating opioid use disorder. Researchers will compare a low-intensity and a high-intensity support strategy to see which one works better. The goal is to get more patients to start medication for opio…

This study tests whether texting pregnant women about mental health and substance use helps them get treatment faster and stick with it, compared to standard in-person screening. Over 10,000 pregnant women aged 18-45 at MUSC clinics will take online questionnaires. The goal is to…

This study aimed to understand how a person's socioeconomic status (like income, education, and housing) affects their recovery from substance use disorders. Researchers planned to follow adults in early recovery for up to three years, measuring changes in social status, decision…

This study aimed to see if a brain training method called ZQLN could improve brain activity and thinking skills in people with cocaine use disorder. It was planned for adults aged 21 to 51 who had completed detox. However, the study was withdrawn before enrolling anyone, so no re…

This study from Mayo Clinic tests a smartphone app designed to help primary care doctors screen, briefly counsel, and refer patients with substance use disorders to treatment. Researchers will enroll 60 adults to understand what helps or hinders using this digital tool in real cl…

This study follows 120 people in group therapy for alcohol use disorder to see which patient traits—like mental health, drinking severity, personality, or thinking skills—predict success. Researchers want to help doctors choose the right therapy for each person. The goal is bette…

This study looks at how people react to stress in a pretend emergency room. Researchers will have 20 people who use meth and 10 healthy adults do public speaking and math tasks. They want to see if this setup feels like a real ER and measure stress through saliva, blood pressure,…

This study aimed to see if a non-invasive brain stimulation technique called cTBS could reduce cravings in people recovering from methamphetamine use disorder. Researchers planned to enroll 40 adults living in a residential treatment program and use brain scans to measure changes…