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Can online or group programs stop teen depression before it starts?

NCT ID NCT04290754

Prevention Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two different programs designed to prevent depression in teenagers who are at risk. One program is an online course called CATCH-IT, and the other is an 8-session group program called TEAMS. About 636 teens aged 13-19 with mild depressive symptoms but no current depression are taking part across several states. Researchers will compare how well each program works and how acceptable they are to teens and families.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CATCH-IT (online program) and TEAMS (group program)
What this could lead to
If successful, this could provide effective, scalable ways to prevent depression in teenagers before it starts.
What could go wrong
This is a comparative effectiveness trial, not a test of a new drug. Results may show one program is better, but neither may be widely adopted. The study also includes a smaller COVID-era cohort, which may affect consistency.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

636 people

The number who actually took part.

Started

Jan 2020

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 19 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adolescents ages 13 through 19 years, and * Adolescent must be experiencing an elevated level of depressive symptoms (Patient Health Questionnaire-9 Score = 5-18), and * Adolescent will be included if they have a past, but not current history of depression. Exclusion Criteria: * Outside age range * A current diagnosis of Major Depression * Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) diagnosis of: schizophrenia, bipolar affective disorder, extreme current drug or alcohol abuse. * Currently using medication therapy for depression, anxiety, or other internalizing disorders for less than 3 months. * Currently engaged in individual treatment for a mood disorder * Currently engaged in a cognitive-behavioral group or therapy * Any past psychiatric hospitalizations * Any past self-harm attempt with moderate or greater lethality * Current suicidal thoughts * Not willing to comply with the study protocol * Not willing to participate in the TEAMS groups * Not willing to be audio recorded during TEAMS groups (only for TEAMS clinics) * Unable to complete the PHQ-9 screening due to cognitive or intellectual impairment * Did not complete phone assessment with MINI Kid * Parent/guardian has a cognitive or intellectual impairment. * Participant Declined/Changed Mind/Uninterested in participating

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression

Contacts and locations

Locations

  • UI Health

    Chicago, Illinois, 60612, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.