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Is 'Safe' snus actually safe? 30,000-Person study aims to find out

NCT ID NCT07573319

Knowledge-focused Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses data from over 30,000 Swedish adults to see if using snus (including newer white nicotine pouches) is linked to heart disease, metabolic problems, and poor mental health, independent of smoking. Researchers will compare current, former, and never-users using advanced imaging and blood tests. The goal is to clarify the mixed evidence on snus safety.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
snus (including white nicotine pouches)
What this could lead to
If clear links are found, this could guide public health advice and regulation around snus use, especially for young people and women.
What could go wrong
This is an observational study, so it cannot prove cause and effect. Results may be influenced by other lifestyle factors not fully accounted for.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30,154 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2013

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Random selection

Ages

50 to 64 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Cohort Size: Over 30,000 men and women. Locations: Recruited across six Swedish university hospitals: Gothenburg, Malmö/Lund, Linköping, Stockholm, Umeå, and Uppsala. Inclusion criteria: * Age 50-64 years at the time of inclusion * Selection: Randomly selected from the Swedish national population register.

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Conditions

The condition(s) this trial relates to.

atherosclerosis Depression metabolic disease nicotine dependence Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular (CV) risk Mental health Metabolic abnormalities Nicotine

Contacts and locations

Locations

  • Göteborg Universitetssjukhus

    Gothenburg, Sweden

  • Karolinska Institutet Danderyds Sjukhus

    Stockholm, Sweden

  • Skanes Universitetssjukhus, Lund Universitet

    Lund, Sweden

  • Umeå Universitetssjukhus

    Umeå, Sweden

  • Uppsala Universitetssjukhus

    Uppsala, Sweden

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