HIIT bikes may boost brain power in breast cancer patients on chemo

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written informed consent prior to any study-related procedures * Women newly diagnosed (Stage I-III) breast cancer. * Over the age of 18 years; children under the age of 18 will be excluded due to rarity of disease * The effects of exercise on the developing fetus are unknown. For this reason, women of child-bearing potential must agree to undergo a pregnancy test and to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately. * Will receive (neo)adjuvant chemotherapy * Speak English * Able to provide physician clearance to participate in the exercise program * Able to initiate a supervised exercise program (free from any cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity) * Have not experienced a weight reduction ≥10% within the past 6 months * Currently participate in less than 60 minutes of structured exercise/week * Does not smoke (no smoking during previous 12 months) * Willing to travel to DFCI for assessments (54 visits total for those who elect the exercise group with on campus training session, 6 visits for those that elect the exercise at home option, 6 visits for those assigned to the control group) * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension or thyroid disease * Patients with other active malignancies are ineligible for this study. * Patients with metastatic disease * Medical history of coronary heart or artery disease, chronic or acute congestive heart failure or history of systolic or diastolic insufficiencies * Participates in more than 60 minutes of structured exercise/week * Orthopedic or other restrictions or contraindications to high-intensity (cycling) exercise * Have a pacemaker or any implantable device that are not MRI safe; the BWH/DFCI Standard MRI screening form * Is unable to travel to DFCI * Patients who are pregnant * Patients with claustrophobia * Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study.