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Could epidurals shield new mothers from postnatal depression?

NCT ID NCT03167905

Prevention Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial asks whether the type of pain relief a woman receives during labor can influence her risk of developing postnatal depression. About 10-15% of new mothers experience postnatal depression, and this study compares epidural analgesia with non-epidural options like laughing gas or injectable painkillers. Researchers will track mood and persistent pain in healthy women delivering a single baby at term. The goal is to see if one approach better supports emotional well-being after childbirth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Epidural analgesia (ropivacaine with fentanyl) versus non-epidural options (Entonox, meperidine, remifentanil)
What this could lead to
If epidural pain relief lowers the chance of postnatal depression, it could guide safer, more supportive choices for women during childbirth.
What could go wrong
The trial is in earlier phases and results may not apply to all women. Epidurals carry their own risks, and the link between pain relief and depression is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

881 people

The number who actually took part.

Started

Jun 2017

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy adult (American Society of Anesthesiologists physical status 1 and 2) parturients at term (36 weeks gestation or more) (nulliparous and multiparous); * With a singleton fetus. Exclusion Criteria: * Multiple pregnancies; * Non-cephalic fetal presentation; * Obstetric complications (e.g. pre-eclampsia, uncontrolled hypertension, uncontrolled diabetes); * Elective and urgent caesarean section (not from delivery suite).

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Conditions

The condition(s) this trial relates to.

agnosia postpartum depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia, obstetrical Anesthesia, obstetrical Depression, postpartum

Contacts and locations

Locations

  • KK Women's and Children's Hospital

    Singapore, 229899, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.