Could nurse home visits help psychosis patients in malawi?
NCT ID NCT06080477
First seen Jun 26, 2026 · Last updated Sep 01, 2026 · Updated 3 times
Summary
This pilot study tested whether a nurse-led community-based rehabilitation program is feasible and acceptable for people with psychosis in Blantyre, Malawi. Sixty adults with psychosis were randomly assigned to either usual care or the home-based program. The study focused on recruitment, retention, satisfaction, and session attendance, not on whether the program improves symptoms.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nurse-delivered community-based rehabilitation (behavioral intervention)
- What this could lead to
- If successful, this could point toward a scalable, low-cost way to improve mental health outcomes for people with psychosis in low-resource settings.
- What could go wrong
- This is a small pilot study (60 participants) testing feasibility, not effectiveness. Results may not generalize to other regions or populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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178 people
The number who actually took part.
- Started
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Dec 2023
- Finished
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Aug 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria for PWLE: * Current outpatient at Queen Elizabeth Central Hospital psychiatry clinic * Age 18 or older * Diagnosis of schizophrenia spectrum disorder or clinical presentation of symptoms of hallucinations, delusions or thought disorder that persisted for longer than one month and are accompanied by significant functional impairment * Resident in Blantyre District * Not planning to relocate out of Blantyre District in next 12 months * Has a primary caregiver willing to participate in the study * Has current elevated symptoms or poor functioning as demonstrated by one or more of: Positive and Negative Symptoms Scale score ≥58 WHO Disability Assessment Schedule 2.0 score ≥35 Clinical Global Impression Severity score ≥2 (at least mildly ill) Inclusion Criteria for Caregivers: * Is a current caregiver for an eligible and consenting patient participant. * Age 18 or older * Resident in Blantyre District * Not planning to relocate out of Blantyre District in next 12 months Exclusion Criteria for PWLE: * Not a current outpatient at Queen Elizabeth Central Hospital psychiatry clinic * Not Age 18 or older * No diagnosis of schizophrenia spectrum disorder or clinical presentation of symptoms of hallucinations, delusions or thought disorder that persisted for longer than one month and are accompanied by significant functional impairment * Not a resident in Blantyre District * Planning to relocate out of Blantyre District in next 12 months * Does not have a primary caregiver willing to participate in the study * Does not have current elevated symptoms or poor functioning as demonstrated by one or more of: Positive and Negative Symptoms Scale score ≥58 WHO Disability Assessment Schedule 2.0 score ≥35 Clinical Global Impression Severity score ≥2 (at least mildly ill) Exclusion Criteria for Caregivers: * Is not a current caregiver for an eligible and consenting patient participant. * Not Age 18 or older * Not a resident in Blantyre District * Planning to relocate out of Blantyre District in next 12 months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Queen Elizabeth Central Hosptial
Blantyre, Malawi
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Other studies related to the condition(s) this trial covers.
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