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Brain training may ward off depression in vulnerable teens

NCT ID NCT04346784

Prevention Sponsor: Hunan Normal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study tests whether computer-based training that targets emotional memory or attention can prevent major depression in young people who have depressive symptoms or have recovered from a depressive episode. Participants are randomly assigned to one of three active training programs or a placebo, completing daily sessions for two weeks, with a booster at six months. They are followed for five years to see if they develop a major depressive episode and to identify cognitive factors that predict depression onset.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Computer-based emotional working memory training (positive or negative) or attention bias training
What this could lead to
If effective, this could offer a non-drug, brain-training approach to prevent major depression in young people at risk.
What could go wrong
The training is brief and the trial is relatively small, so effects may be modest or not last. It is also unclear if results will apply to all youth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

110 people

The number who actually took part.

Started

Oct 2019

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 21 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scores of the Beck Depression Inventory-II version (BDI-II) of a participant are equal to or more than 14. Exclusion Criteria: A participant with * A current episode of MDD, bipolar disorder, schizophrenia or organic mental disorder; * Any concurrent psychotherapy; * Any concurrent psychotropic medication.

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Conditions

The condition(s) this trial relates to.

Depression Emotional Regulation major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depressive symptoms Remited major depressive disorder

Contacts and locations

Locations

  • Department of Psychology, Hunan Normal University

    Changsha, Hunan, 400081, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.