DEPRESSIVE SYMPTOMS

This study tests whether combining exercise with cognitive behavioral therapy (CBT) can improve blood sugar control and quality of life in Black men with type 2 diabetes and depressive symptoms. About 80 participants will receive CBT, and half will also get guided exercise sessio…

This study tests a program called Family Spirit Strengths to help Native American and Alaska Native mothers and caregivers manage depression, anxiety, and substance use. About 188 participants will either receive the skills program or a nutrition education program. The goal is to…

This study tests whether taking part in racial justice activism can help prevent depression and reduce physical stress in Black and Latinx teens and young adults (ages 15-20). Researchers will measure depressive symptoms and stress-related health markers like blood pressure and w…

This study tests whether lifestyle changes—like regular exercise, a Mediterranean diet, and cognitive training—can prevent memory and thinking problems in adults aged 50-80 who have depression or depressive symptoms but no current cognitive decline. Researchers will compare three…

This study tests a school-based program called 'Op Volle Kracht' to prevent depression and suicide in teens attending special education schools. About 236 students with mild depressive symptoms will either receive the program or be monitored. The goal is to see if the program red…

This early-phase study is testing whether psilocybin, a hallucinogenic drug, can safely help with depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive the drug in a supportive setting. The main goal is to see if depres…

This study tests a simple, 3-session expressive writing program to help sexual minority veterans cope with stress related to their identity and reduce symptoms of depression and anxiety. Researchers will enroll 85 veterans who identify as gay, lesbian, bisexual, or queer and have…

This study tests a culturally adapted internet-based therapy for Farsi/Dari-speaking migrants and refugees aged 15-29 who have mild to moderate anxiety or depression. Participants will receive the therapy over 6-10 weeks, and researchers will measure changes in symptoms compared …

This study is testing a mobile app called MAYA that teaches coping skills for anxiety and depression. About 60 adults aged 40 and older with anxiety or mood disorders will use the app for 20 minutes, at least twice a week, for six weeks. Researchers want to see if people find the…

This study tests if a non-invasive magnetic brain stimulation technique (rTMS) can safely reduce depression symptoms in 198 U.S. military service members and veterans who have had a concussion. Participants receive either active or sham stimulation to the front of the brain. The …

This study tests a special support program called POSTCARE-O for women with ovarian cancer who have finished their initial treatment. The goal is to see if this program can improve quality of life and reduce depression compared to usual care. The study will involve 120 women and …

This study looks at how stress, sleep, and activity affect the mood and brain health of people caring for a loved one with dementia. About 120 caregivers aged 55 and older will receive one of two types of talk therapy. Researchers will track changes in depression, anxiety, and sl…

This study tests whether a special sleep education program can improve sleep quality and reduce depression in menopausal women. About 500 women will be randomly assigned to either receive the education or be in a control group. The program teaches good sleep habits based on the I…

This study looks at whether music therapy can improve mental health and social connections in university students who are feeling depressed, anxious, or stressed. Twenty students will be randomly assigned to either a music therapy group (writing songs) or a control group (listeni…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to improve brain function and reduce symptoms. The goal is to help 120 adults with treat…

This study is testing whether two devices used together (EXOMIND and EMSELLA) can help improve depressive symptoms and sexual function in women going through menopause or perimenopause. About 60 women aged 40 and older will receive twelve treatments and complete questionnaires ab…

This study is testing a 7-week online program called My Wellbeing Guide to see if it can reduce depression and anxiety in cancer patients. About 6,500 adults with cancer and high depressive symptoms will be randomly assigned to use the program or a control app with resource links…

This study tests a non-invasive brain stimulation method called MRI-guided transcranial direct current stimulation (mgTDCS) to see if it can improve depression, apathy, and working memory in people with Parkinson's disease. About 40 participants with Parkinson's and elevated depr…

This study tests a telemedicine program called RxWell that teaches coping skills to manage mood and pain after knee or hip replacement. About 150 adults with anxiety or depression symptoms will use the program before and after surgery. The goal is to see if it reduces the need fo…

This study tests a mobile app called Moodivate to help treat depression in people with incurable cancer. About 279 participants will either use the app or not for 12 weeks. The goal is to see if the app reduces depressive symptoms and improves quality of life. Risks include frust…

This study tests an 8-week group program that teaches meditation, breathing, and relaxation skills to help medical graduate students manage mood symptoms like anxiety and depression. About 60 students with mild to moderate symptoms will participate. The goal is to see if the prog…

This study tests whether two devices used together can help reduce depressive symptoms and urinary incontinence in women who gave birth 2 to 60 months ago. About 60 women will receive twelve treatment sessions and complete questionnaires about their mood, bladder control, and wel…

This study is testing a web-based program called CAI that helps Asian American breast cancer survivors manage cancer pain and related depressive symptoms. The program builds on an earlier version by adding personalized coaching and support. Researchers will enroll 300 women of Ch…

This study tests a smartphone app that sends brief social support messages to adults with depression who are waiting for outpatient therapy. Over 21 days, 120 participants will be randomly assigned to receive messages at different times or no messages at all. The goal is to see i…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) works better when combined with virtual reality (VR) for burn survivors. About 34 adults who have had a burn injury for at least 6 months and still have symptoms like pain, itch, or sleep p…

This study is testing whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain for people with chronic low back pain, with or without mild-to-moderate depression. About 80 adults will receive either CBD or a placebo for a period o…

This study tests whether doing tai chi and qigong online can reduce depressive symptoms in people aged 50-75 living with HIV. Participants will take either a 12-week tai chi class or a health education class, both via Zoom. Researchers will compare the groups to see if tai chi im…

This study is observing 500 adults with type 2 diabetes to understand how their mental well-being, depression, and quality of life are connected. Participants will fill out questionnaires about their feelings and daily life. The goal is to find patterns that can help doctors offe…

This study follows 500 adults with depression, bipolar disorder, or suicide risk who are already receiving care. Researchers will use interviews, questionnaires, and optional tests like blood draws and brain scans to track how symptoms change over time. The goal is to find better…

This study looks at whether bright light therapy (BLT) can help reduce depressive symptoms in adults with intellectual disabilities. Many standard treatments are hard to use for this group, but BLT is simple and has shown promise without serious side effects. The study will invol…

This study is following 2,500 adults in Puerto Rico, ages 30 to 75, to learn how stress, diet, and living environment affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years. The goal is to gui…

This study talks to 15 children aged 8–12 who have depressive symptoms, and their parents, to learn what everyday stresses they face and how they cope. The goal is to use this information to create a fun app that teaches emotional skills through games. No treatment or medication …

This study compares two programs—Mindfulness-Based Cognitive Therapy and a general wellness program—to see which one better helps people with mild depression control their emotions. About 76 adults with low-level depression symptoms will complete surveys, interviews, and computer…