Depressive symptoms

This trial explores whether an archery exercise program can improve sleep quality, emotional well-being, and brain function in college students who have depressive symptoms. Participants will be randomly assigned to either an 8-week archery training program or their usual routine…

This study tests whether a nasal spray containing esketamine and dexmedetomidine, given twice after childbirth, can lower the chance of postpartum depression in women who already had mild depressive symptoms during pregnancy. Esketamine is a fast-acting antidepressant, and dexmed…

This study tests a program called NPOWER365 for Black men who have sex with men and are living with HIV. The program uses a smartphone app, online forums, and resource referrals to help with medication adherence, mental health, and access to care. About 350 participants in the At…

This study explores whether routine blood vessel tests can help identify depression in people with chronic atrophic gastritis, a stomach condition. Many patients with this disease have undiagnosed depression due to stigma. Researchers will use ultrasound and other vascular measur…

This trial tests a school-based program that uses an AI chatbot to teach high school students about depression, reduce stigma, and encourage them to seek professional help when needed. About 720 students aged 15 to 19 in Taiwan will take part in four weekly sessions, with some re…

This study tests whether trained youth mentors can deliver a brief therapy to reduce suicide risk in Hispanic adolescents aged 12-17. Participants will either receive 6 therapy sessions with a mentor or usual care. The goal is to see if this approach is feasible and helps reduce …

This study tests a community-based program to help Black and Hispanic teens aged 15-20 cope with chronic stress and prevent depression. Participants will join peer groups to learn skills and will be tracked for 2 years. The goal is to reduce depressive symptoms and improve physic…

This study tests whether replacing some regular gym classes with specialized physical education courses can prevent common health issues like nearsightedness, overweight, anxiety, and depression in junior high students. Two hundred students will be randomly assigned to either the…

Researchers at the University of Bergen are testing whether a two-week, self-guided smartphone screen time reduction program can reduce depression symptoms in young adults. The trial enrolls 200 students in Oslo who have sought help at the student mental health service. Participa…

Researchers at Beijing Normal University are testing whether a guided nature photography program can ease mild depression and anxiety in young adults. Around 300 participants with mild emotional distress will be randomly assigned to take nature photos, take photos of human-made o…

This study tests whether baricitinib, an anti-inflammatory drug, can improve depression and cognitive symptoms in 30 male former football players aged 40-55 with at least 10 years of play. Participants take the drug every other week for 6 weeks, and researchers use brain scans an…

This trial tests whether giving a combination of dexmedetomidine and esketamine during and after laparoscopic ureteral reconstruction can reduce depressive symptoms and anxiety in patients. The study enrolls 658 adults with ureteral stricture who are scheduled for this surgery. P…

This pilot study tests a group-based cognitive stimulation program using virtual reality for people aged 65 and older who have depressive symptoms and attend Portuguese day centers. The program aims to improve cognitive function, well-being, and daily functioning while reducing d…

This study tests whether a smartphone app called MindfulCityU can help university students with mild depressive symptoms feel better. 120 students will either use the app for four weeks or join a waitlist. Researchers will measure changes in depression, anxiety, stress, and mindf…

This study tests whether mindfulness-based cognitive therapy (MBCT), adapted for Vietnamese culture, can reduce depression symptoms and improve quality of life. One hundred sixty adults with mild-to-moderate depression will be recruited from eight Buddhist pagodas near Hanoi. Hal…

This study explores whether a single low-dose ketamine infusion can reduce depressive symptoms in adults with epilepsy who are already undergoing brain monitoring for their seizures. Participants receive one intravenous dose of ketamine while their brain activity is recorded dire…