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Could a Two-Drug anesthesia combo lift Post-Surgery mood?

NCT ID NCT07753772

Symptom relief Sponsor: Peking University First Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This trial tests whether giving a combination of dexmedetomidine and esketamine during and after laparoscopic ureteral reconstruction can reduce depressive symptoms and anxiety in patients. The study enrolls 658 adults with ureteral stricture who are scheduled for this surgery. Participants are randomly assigned to receive the drug combo or a standard approach, and their mood is assessed using a questionnaire before discharge. The goal is to see if this low-dose combination can improve emotional recovery without increasing side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A combination of two anesthetic drugs, dexmedetomidine and esketamine, given during and after surgery to potentially improve mood.
What this could lead to
If effective, this approach could offer a simple way to reduce post-surgical depression and anxiety in patients undergoing ureteral repair, improving recovery and quality of life.
What could go wrong
The trial is early and results may not apply to all surgeries. Both drugs have side effects, including low heart rate, low blood pressure, and psychiatric effects, which the study will monitor.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 658 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged ≥ 18 years; 2. Diagnosed with ureteral stricture and scheduled for elective laparoscopic ureteral reconstruction under general anesthesia; 3. Requiring patient-controlled intravenous analgesia after surgery. Exclusion Criteria: 1. Preoperative inability to communicate due to coma, delirium, severe dementia, or language barrier; 2. History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis; 3. Presence of preexisting left ventricular ejection fraction (LVEF) \< 30%, sick sinus syndrome, severe sinus bradycardia (heart rate \< 50 beats/min), or atrioventricular block above grade II without pacemaker implanted; 4. Uncontrolled hyperthyroidism or history of pheochromocytoma; 5. Severe hepatic insufficiency (Child-Pugh Class C), severe renal insufficiency (required preoperative dialysis), or American Society of Anesthesiologists (ASA) physical status classification ≥ IV; 6. Allergy to dexmedetomidine and/or esketamine; 7. Other conditions deemed unsuitable for study participation by the investigators.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Depression stricture or kinking of ureter

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Depressive symptoms Dexmedetomidine Esketamine Ureteral stricture

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Peking University First Hospital

    Beijing, Beijing Municipality, 100034, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.