DEXMEDETOMIDINE

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. Researchers will enroll 2,400 adults aged 60 and older who are having bypass or valve surgery. Participants will receive either dexm…

This study tests whether a nasal spray containing two medicines (dexmedetomidine and esketamine) can reduce pain in children after tonsil and adenoid surgery. About 160 children aged 3 to 7 will take part. The goal is to find a safe and effective way to manage pain without strong…

This study compares the standard drug pregabalin alone versus pregabalin combined with dexmedetomidine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers hope the combination will provide greater pain relief without more side effects. The tria…

This study tests whether giving the drug dexmedetomidine at different times before surgery can lower the body's stress response when a breathing tube is placed. About 45 adults having surgery will be randomly assigned to receive the drug at different times. The goal is to see if …

This study compares three sedation methods (dexmedetomidine, propofol, or both) in 1,000 adults having cataract surgery. The goal is to see which approach provides the best comfort and safety, including effects on heart rate, breathing, and side effects like nausea. Participants …

This study looks at whether combining two sedatives—dexmedetomidine and esketamine—can reduce delirium (sudden confusion) in older patients recovering in the ICU after surgery. Delirium is common and can lead to worse outcomes. The trial will involve 100 adults aged 60 and older …

This study tests whether adding two pain medicines (dexmedetomidine and fentanyl) to standard spinal anesthesia provides better pain relief after above-knee amputation for lower limb sarcoma. About 58 adults aged 18-60 will be randomly assigned to receive either the drug combinat…

This study tests whether lidocaine or dexmedetomidine works better for pain relief after laparoscopic sleeve gastrectomy (weight loss surgery). Forty adults aged 20-50 with a BMI of 35-50 will receive one of the two drugs during surgery. Researchers will measure pain levels, how …

This study tests whether giving dexmedetomidine and esketamine during and after surgery helps patients feel better and recover faster. About 316 adults having surgery under general anesthesia will take part. The goal is to see if these drugs improve pain, comfort, and emotional w…

This study tests whether a nasal spray of dexmedetomidine can reduce agitation in children aged 3-6 after strabismus (eye muscle) surgery. 120 children will receive either a 2 mcg/kg or 3 mcg/kg dose. The goal is to find the best dose to help children wake up calmly and comfortab…

This study tests a nasal spray combining two medicines (dexmedetomidine and esketamine) to help children aged 1-6 relax before surgery. The goal is to find the best dose that makes kids calm enough for a smooth start to anesthesia. 80 children will participate, and researchers wi…

This study tests whether using virtual reality (VR) goggles or a sedative drug called dexmedetomidine is better at reducing anxiety and stress in women having a planned cesarean section. About 52 mothers will be randomly assigned to one of the two methods. The goal is to find a s…

This study tests two different drug mixtures given as a nerve block to control pain after lower abdominal surgery. The goal is to see which combination provides longer pain relief. Sixty adults having lower abdominal surgery will take part.